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Authors:  Vijay C Pujar,* Santosh Kurbet, Deepak K Kaltar

Institute: Department of Paediatric Surgery, J.N.Medical College Belgaum Karnataka, India

Address for Correspondence: Dr. Vijay C Pujar  Professor and Head Dept of Paediatric Surgery Jawaharlal Nehru Medical College Belgaum-590010 Karnataka, India

          *Email: vcpujar@hotmail.com



Journal of Neonatal Surgery

Volume 1(1), Jan-Mar 2012

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Submitted On: 20-10-2011

Accepted On: 12-11-2011

 Published on: 01-01-2012

Local ID: jns-2012-1-3

J Neonat Surg 2012;1(1):6

© Pujar et al 2012, EL-MED-Pub Publishers

Conflict of Interest: None declared

Source of Support: Nil


How to cite:

Pujar VC, Kurbet S, Kaltari DK. Pyloric atresia in association with multiple colonic atresias in a neonate: an unreported association. J Neonat Surg 2012; 1:6.



Pyloric atresia is rare cause of gastrointestinal obstruction in neonates and usually occurs as an isolated anomaly. They have been associated with multiple small bowel and colonic atresias but not reported in association with isolated multiple colonic atresias. A case of pyloric atresia oc-curring in association with multiple colonic atresias is being reported here.

Key words: congenital pyloric atresia, multiple colonic atresias



Pyloric atresia is rare cause of gastrointestinal (GI) ob¬struction in a neonate and usually occurs as an isolated abnormality [1]. Multiple colonic atresias are another rare cause of GI obstruction in neonates. They are not known to occur together. We encountered a neonate with presence of these two anomalies. No similar asso¬ciation has been reported in literature to the best of our knowledge.


A 1-day-old (weight 2.5kg) male neonate, born out of non consanguineous marriage by full term vaginal deli­very was referred to us with distension of abdomen and failure to pass meconium since birth. No antenatal de­tails were available. On examination neonate was he­modynamically stable. Abdomen was grossly distended with stretched shiny skin. Erythema was present in the periumbilical region indicating underlying peritonitis.

Both the scrotal sacs were filled with fluid. Routine he­matology investigations were within normal limits.
Erect X-ray abdomen revealed single air fluid level in the Lt. Upper quadrant with rest of abdomen having ground glass appearance with specks of calcifica­tion seen in left flank area (Fig. 1).


Figure 1: Radiograph showing single air bubble with calcifications in left flank

Baby was resuscitated with nasogastric tube drainage, IV fluids and antibiotics. Provisional diagnosis of upper gastro-intestinal obstruction with associated peritonitis was made. At operation the peritoneal cavity was filled with meconium stained fluid. Small bowel, caecum and part of ascending colon were dilated. A large perforation was noticed on the anti-mesenteric border of the as­cending colon. Multiple colonic atresias were present distal to the perforation site, near the hepatic flexure and in transverse colon (intra luminal webs Type I) (Fig. 2).



Figure 2: Type I transverse colon atresia.


Two more Type II atresias were noticed near the recto sigmoid junction. Resection of atretic segments with end to back anastomosis at three sites and removal of intra luminal web were done along with cov­ering ileostomy.

Gastrotomy done proximal to the pylorus revealed type I A pyloric atresia (complete Web). There was no discon­tinuity at pylorus. Resection of pyloric web with pylo­roplasty (Heineke-Mikulicz) was done. Gastrostomy was done by putting 8-Fr Malecot’s catheter. Bilateral flank drains were inserted.
Post operatively baby required ventilator support and frequent assessment for fluid and electrolyte levels. Feeds were started through gastrostomy tube on 10th post operative and drain removed on 10th postoperative day. The patient is doing well and on follow up for ileostomy reversal.



Congenital pyloric atresia (CPA) is a very rare condition that was first described by Calder in 1749.Its incidence is approximately 1 in 100,000 newborns and constitutes about 1% of all intestinal atresias [1,2].

Anatomically, Pyloric Atresia is divided into three differ¬ent anatomical varieties: type A is a prepyloric mem¬brane, type B a solid core of tissue replacing the pyloric canal, and type C an atretic pylorus with a gap between stomach and duodenum [3].

The diagnosis of pyloric atresia may be suspected from plain abdominal films consistent with a dilated stomach with the typical ‘single bubble’ appearance as seen in our case [4]. Ultrasonography, said to be specific for this condition was not performed in our case.

Pyloric atresia may occur as an isolated condition or associated with other abnormalities, the most common being junctional epidermolysis bullosa (EB), a rare auto¬somal recessive disorder affecting the skin and mucosa [3-6]. However, its association with multiple colonic atresias is not reported to date; though it has been re¬ported in association with multiple small bowel and colonic atresias.

Colonic and pyloric atresias have a different embryologi¬cal basis and different period of occurrence. Colonic atresia is a late event usually occurs beyond 24 weeks of gesta¬tion. Whereas, pyloric atresia is thought to result from developmental arrest between the 5th and 12th weeks of intrauterine life [2,7].

The treatment of CPA is surgical. For pyloric diaphragm or pyloric atresia without a gap, the treatment is exci¬sion of the diaphragm and Heineke-Mikulicz pylorop¬lasty. Intraoperatively it is important to locate the site of obstruction especially in those with a diaphragm, and to obviate missing a windsock diaphragm, a catheter should be passed distally via a small gastrostomy. This is also of importance in case there is more than one diaphragm. For those with pyloric atresia with a gap, if the gap is short, they should be treated with a Finny or Heineke-Mickulicz pyloroplasty, but if the gap is long then a gastroduodenostomy becomes the treatment of choice [7].

In conclusion, our case is unique because of occurrence of both anomalies in the same patient. No similar report was found in the literature.


  1. Bronsther B, Nadeau MR, Abrams MW. Congenital pyloric atresia: a report of three cases and review of literature. Surgery 1971; 69: 130–6.
  2. Paolo Toma, Elena Mengozzi, et al. Pyloric atresia: report of two cases. Pediatr Radiol 2002; 32: 552–5.
  3. Muller M, Morger R, Engert J. Pyloric atresia: report of four cases and review of the literature. Pediatr Surg Int 1990; 5: 276-2.
  4. Okoye BO, Parikh DH, Buick RG, et al. Pyloric atresia: five new cases, a new association, and a review of the literature with guidelines. J Pediatr Surg 2000; 35:1242– 5.
  5. Guttman FM, Braum P, Gavance PH, et al. Multiple atresias and a new syndrome of hereditary multiple atresias involving the gastrointestinal tract from stomach to rectum. J Pediatr Surg 1973; 8: 633–40.
  6. Al-Salem AH, Qaisaruddin S, Varma KK. Pyloric atresia associated with intestinal atresia. J Pediatr Surg 1997; 32: 1262-3.
  7. Puri P, Fulimoto T. New observation of pathogenesis of multiple atresia. J Pediatr Surg 1988; 23: 221-5.

This is an Open Access article distributed under the terms of the Creative Commons Attribution unported License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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