An Overview on Vascular Calcification in Chronic Kidney Disease

Authors

  • Mostafa Mahmoud Salah Ibrahim
  • Ezzat Mostafa Mohammed
  • Hossam Eldin Mansour Abdel Rahman
  • Abeer Abd Alla Fikry Abdel-Rahaman
  • George Emad Shaker
  • Amr Galal Ibrahim Yousef
  • Malak Emad Samy, Ahmed Ezzat Mostafa
  • Fatima Al Taher Taha Morsi

Keywords:

Vascular calcification, chronic kidney disease, mineral bone disorder, cardiovascular disease, inflammation

Abstract

Vascular calcification (VC) is a prevalent and severe complication in chronic kidney disease (CKD), contributing significantly to cardiovascular morbidity and mortality. Its pathogenesis involves disordered mineral metabolism, chronic inflammation, and vascular smooth muscle cell trans differentiation.

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References

Kim, J. S. & Hwang, H. S. 2021. Vascular calcification in chronic kidney disease: distinct features of pathogenesis and clinical implication. Korean circulation journal, 51, 961-982.

Fang, Y., Ginsberg, C., Sugatani, T., Monier-Faugere, M. C., Malluche, H. & Hruska, K. A. 2014. Early chronic kidney disease-mineral bone disorder stimulates vascular calcification. Kidney Int, 85, 142-50.

Jinnouchi, H., Sakamoto, A., Torii, S., Virmani, R. & Finn, A. V. 2019. Types and pathology of vascular calcification. Coronary Calcium. Elsevier. 1-25.

Reiss, A. B., Miyawaki, N., Moon, J., Kasselman, L. J., Voloshyna, I., D'Avino, R., Jr., et al. 2018. CKD, arterial calcification, atherosclerosis and bone health: Inter-relationships and controversies. Atherosclerosis, 278, 49-59.

Kim, Y., Cho, J. S., Cho, W. K., Yoon, H. E., Hong, Y. A., Chang, Y. K., et al. 2017. Retinopathy and left ventricular hypertrophy in patients with chronic kidney disease: Interrelationship and impact on clinical outcomes. Int J Cardiol, 249, 372-376.

Hwang, H. S., Cho, J. S., Hong, Y. A., Chang, Y. K., Kim, S. Y., Shin, S. J., et al. 2018. Vascular calcification and left ventricular hypertrophy in hemodialysis patients: interrelationship and clinical impacts. Int J Med Sci, 15, 557-563.

Benz, K., Varga, I., Neureiter, D., Campean, V., Daniel, C., Heim, C., et al. 2017. Vascular inflammation and media calcification are already present in early stages of chronic kidney disease. Cardiovasc Pathol, 27, 57-67.

Mori, D., Matsui, I., Shimomura, A., Hashimoto, N., Matsumoto, A., Shimada, K., et al. 2018. Protein carbamylation exacerbates vascular calcification. Kidney Int, 94, 72-90.

Voelkl, J., Cejka, D. & Alesutan, I. 2019. An overview of the mechanisms in vascular calcification during chronic kidney disease. Curr Opin Nephrol Hypertens, 28, 289-296.

Lee, S. J., Lee, I.-K. & Jeon, J.-H. 2020. Vascular calcification—new insights into its mechanism. International journal of molecular sciences, 21, 2685.

Pérez-Hernández, N., Aptilon-Duque, G., Blachman-Braun, R., Vargas-Alarcón, G., Rodríguez-Cortés, A. A., Azrad-Daniel, S., et al. 2017. Vascular calcification: current genetics underlying this complex phenomenon. Chinese medical journal, 130, 1113-1121.

Zaslow, S. J., Oliveira-Paula, G. H. & Chen, W. 2024. Magnesium and Vascular Calcification in Chronic Kidney Disease: Current Insights. International Journal of Molecular Sciences, 25, 1155.

Ter Braake, A. D., Shanahan, C. M. & De Baaij, J. H. 2017. Magnesium counteracts vascular calcification: passive interference or active modulation? Arteriosclerosis, thrombosis, and vascular biology, 37, 1431-1445.

Disthabanchong, S. & Boongird, S. 2017. Role of different imaging modalities of vascular calcification in predicting outcomes in chronic kidney disease. World J Nephrol, 6, 100-110.

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Published

2025-09-24

How to Cite

1.
Salah Ibrahim MM, Mohammed EM, Abdel Rahman HEM, Abdel-Rahaman AAAF, Shaker GE, Yousef AGI, Ahmed Ezzat Mostafa MES, Taha Morsi FAT. An Overview on Vascular Calcification in Chronic Kidney Disease. J Neonatal Surg [Internet]. 2025Sep.24 [cited 2025Dec.7];13(1):1291-5. Available from: https://www.jneonatalsurg.com/index.php/jns/article/view/9219

Issue

Vol. 13 (2024): Journal of Neonatal Surgery

Section

Original Article

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