Neonatal gastric perforation in Twins: Two distinct cases

ABSTRACT


INTRODUCTION
Neonatal gastric perforation (NGP), although rare, accounts for approximately 7% of all gastrointestinal perforations in this age group.[1,2] The exact cause of this condition is not fully understood, the reported causes include iatrogenic gastric perforation with nasogastric tube insertion or barotrauma, a congenital muscular defect of the stomach, a combination of local ischemia in the stomach wall, and high gastric acidity, and secondary to gastric outlet obstructions.[1][2][3][4][5][6][7][8][9].It is rarely reported in preterm twins.Herein, we report two cases of gastric perforation in preterm twins and describe the challenges faced in the management.

CASE SERIES CASE 1:
A second preterm female twin was born at 34 gestational weeks (GW).On the third day of life, the infant exhibited sudden abdominal distension and respiratory distress.Due to the family residing in a remote rural area and the domestic labor commitments, the baby was brought to the hospital by the grandmother on the fourth day.The neonate weighed 1300g upon admission and was immediately transferred to the intensive care unit (ICU).

Physical
examination revealed mottled skin, depressed reflexes, and a distended abdomen.The heart rate was 160-166 beats per minute, blood pressure -70/42 mm Hg, and respiratory rate -42-48 breaths per minute.The laboratory findings indicated a white blood cell count of 2.93×10^9/L with 83.7% neutrophils and thrombocytopenia 86,2×10^9/L.The patient was also identified to have hyponatremia, with a serum sodium level of 120 mmol/L, and metabolic acidosis.An abdominal X-ray revealed the presence of free gas in the abdominal cavity and ultrasound imaging showed the presence of free fluid in the pelvic cavity.Intra-abdominal pressure was approximately 25 cm H2O, as measured by a catheter in the urinary bladder.
To relieve gastric distension, a 6 Fr nasogastric (NG) tube was inserted for gastric decompression without any technical difficulties.Primary peritoneal drainage was performed that drained 30ml of yellowish serum with fibrin and a significant amount of gas.Following that, the patient's hemodynamic state improved a bit.Inotropic support started and correction of fluidelectrolyte balance was done.
After hemodynamic stabilization, the patient underwent exploratory laparotomy that showed yellow fibrin flakes covering intestinal loops (Fig. 1A).The exploration of the stomach revealed a perforation in the pre-pyloric region, with the NG tube protruding through it (Fig. 1B).The origin of the stomach wall perforation and its relationship to the presence of the NG tube as the initial cause remained controversial.The perforation was promptly repaired.Despite surgical intervention and meticulous postoperative care, the patient continued to deteriorate and died on the first postoperative day.At that moment, the first twin is alive and in good general health.

CASE 2:
A set of dichorionic diamniotic female twins was delivered prematurely at 32 GW through a cesarean section.The mother, aged 36, had previously worked in a chemical plant.The first pregnancy is through in vitro fertilization.The second twin suffered perinatal central nervous system damage and passed away shortly after birth.
Due to the sudden development of abdominal distension and respiratory distress syndrome, the first twin was transferred to the ICU and placed on continuous positive airway pressure (CPAP).Free gas was detected via abdominal X-rays.The patient had thrombocytopenia indicating an advancing NEC.The patient was then given medical preoperative preparation and underwent primary peritoneal draining.Empirical antibacterial therapy was initiated.Intraoperatively, an extensive intramural rupture along the lesser curvature of the stomach was identified, extending from the cardiac region to the beginning of the duodenum (Fig. 2).The stomach was repaired.
Postoperatively, the baby required multiple blood component transfusions due to ongoing hemorrhagic complications.Thrombocytopenia was observed and progressively worsened and manifested as a hemorrhagic rash when the platelet count reached 48×10^9/L, necessitating consultation with a hematologist.Thrombocytopenia was likely a result of the septic process, and low-dose hormonal therapy with prednisolone was initiated.Platelet concentrate transfusions were also administered to manage the thrombocytopenia.Enteral feeding was gradually reintroduced, starting with saline solution and then with formula feed, while closely monitoring the baby's response.With appropriate medical care and multidisciplinary support, the baby showed signs of improvement, including the resolution of abdominal distension, improvement in respiratory and hemodynamic parameters shortly after the surgical procedure, and a reduction in coagulopathy later.After a postoperative period of 18 days, the baby was discharged from the hospital.No gastrointestinal issues have been observed in the long-term follow-up.

DISCUSSION
The origins of Neonatal gastric perforation (NGP) have been debated for many years, although recent research points to spontaneous stomach perforation as being more frequent in newborns than iatrogenic perforation.Despite the rarity of iatrogenic gastric perforation, forceful bag-mask ventilation and perforation brought on by the insertion of an orogastric or nasogastric tube may have been linked.[5] According to our hypothesis, NGP usually affects newborns who have a predisposition, like an underdeveloped stomach wall.It is unclear in the first case whether the placement of the nasogastric tube itself contributed to the perforation or if there was a pre-existing condition that caused both the stomach perforation and the subsequent displacement of the NG tube.
Excessive gastric distension has also been mentioned as a possible iatrogenic cause.[9,10] This condition might be brought on by improper tracheal intubation or the presence of a tracheo-esophageal fistula.However, in the second instance, the use of CPAP as the primary cause of NGP is still debatable.It is crucial that newborns' stomach walls can exhibit signs of weakness or immaturity, making them more susceptible to rupture during medical procedures.
The occurrence of NGP in premature newborns presents significant challenges in terms of diagnosis and management.It is rarely reported in twins.It is essential to identify the disease promptly and distinguish it from other gastrointestinal perforations in newborns.The most frequent diseases that should be taken into account when making a differential diagnosis of NGP are NEC and SIP.[9] Although preterm neonates and low-birth-weight neonates make up the majority of patients with these disorders [2], they may display slightly different clinical patterns.
NGP commonly happens between the ages of two and seven days.[1,2] In our cases, the median age at which symptoms first appeared was about three days.SIP appears to occur more frequently after the second week of delivery, although NEC symptoms normally appear later, commonly after the first week of birth.[8] NGP is associated with several clinical symptoms, which are common for all neonatal gastrointestinal perforations [1], including abdominal distension, feeding intolerance, poor activity, respiratory distress, and abdominal erythema.However, one notable difference in the clinical presentation of NGP compared to NEC and SIP is the presence of sudden shock symptoms, which are more frequently observed in NGP cases.In contrast, the signs of shock in NEC and SIP tend to appear gradually in the advanced stages.
In NGP, the development of sudden shock can be attributed to a component of combined pathogenesis, specifically intra-abdominal hypertension (IAH).[10] In both of the reported cases, there was a rapid increase in intra-abdominal pressure.In NEC, IAH typically develops progressively, whereas in SIP it is not as common or prominent in the initial stages.The presence of sudden shock, coupled with the development of IAH with respiratory distress, distinguishes NGP from NEC and SIP.
Coagulopathy is a secondary complication that can develop in all of the mentioned conditions and often persists as a sign of sepsis in these cases.However, it is worth noting that thrombocytopenia is commonly reported specifically in neonates with stomach rupture.[5,7] Additionally, as seen in the second case, thrombocytopenia tends to manifest earlier and last longer following surgery in this situation.This clinical fact may distinguish NGP from the coagulopathy observed in NEC and SIP.
NGP is a life-threatening condition with the reported overall survival rate is approximately 70.3%.[7] Several retrospective studies [5,7] have identified three independent risk factors associated with mortality in NGP cases: shock, serum lactic acid levels above 2.5 mmol/L, and thrombocytopenia.
The successful management of NGP requires a multidisciplinary approach.While the timing of surgical intervention is crucial, conservative support also plays a significant role in improving outcomes.The reported clinical cases, along with other sources, highlight the importance of timely surgical intervention, meticulous postoperative care, and close monitoring of complications such as sepsis and thrombocytopenia.

CONCLUSION
Neonatal gastric perforation is a challenging condition and is rarely found in preterm twins.A comprehensive and coordinated approach, involving both surgical intervention and intensive care, is necessary to optimize the chances of survival in neonates with NGP.This includes timely surgical intervention, attentive postoperative care, and vigilant monitoring for complications

Figure 1 :
Figure 1: Yellow fibrin flakes covering intestinal loops; B) a perforation in the pre-pyloric region with the NG tube protruding through it.

Figure 2 :
Figure 2: A) An extensive intramural rupture along the lesser curvature of the stomach, from the cardiac region to the initial portion of the duodenum.B) repair is in progress.