Starting from scratch: The primary hyperacidity theory of the cause of pyloric stenosis of infancy


  • Ian Munro Rogers Adjunct faculty AIMST University malaysia



Etiology, Pyloric stenosis of infancy, Neonate, Hypergastrinemia, Hyperacidity, Gastrin


The early observations of those who first described babies with pyloric stenosis (PS) are used as a backdrop for the development of the Inherited Primary Hyperacidity theory of cause. Those early truths, uncomplicated by modern technology, have acted as a springboard for pathogenesis. Hyperacidity, male predominance, family history, self-cure, enhanced appetite, and time-sensitive presentation were all well known to the early pioneers. Any system of pathogenesis must explain all these clinical features. The Inherited Primary Hyperacidity theory does this and is a credible explanation for all the clinical features established by these early pioneers. The evidence which supports a delay in maturation of the negative feedback between gastrin and gastric acidity is presented. Such a phenomenon further supports the Primary Hyperacidity theory.


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How to Cite

Rogers IM. Starting from scratch: The primary hyperacidity theory of the cause of pyloric stenosis of infancy. J Neonatal Surg [Internet]. 2022Jan.14 [cited 2022Dec.3];11:7. Available from:



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