Primary neonatal sacrococcygeal neuroblastoma masquerading as a teratoma: A case report
DOI:
https://doi.org/10.52783/jns.v11.1113Keywords:
Primary, Sacrococcygeal, Neuroblastoma , NeonatalAbstract
Background: Neonatal tumors comprise about 2% of all pediatric malignancies, with neuroblastoma having the highest incidence. Neuroblastoma involving the adrenal medulla and sympathetic ganglia is the most typical scenario in infancy, while the pelvic variant is rare. We report this case because of the unusual and rare presentation of neuroblastoma in a newborn baby mimicking sacrococcygeal teratoma.
Case Presentation: A newborn male baby presented with a firm sacral mass, about 5 x 7 cm, with normal overlying skin. MRI revealed an intrapelvic mass extending to the sacral region encasing the coccyx. After preparation, complete tumor excision was performed, and the diagnosis of neuroblastoma was confirmed by histological and immunohistochemical study.
Conclusion: Primary neonatal neuroblastoma presenting as a sacrococcygeal mass is a rare and atypical clinical finding of neuroblastoma. It is hard to diagnose this sort of tumor preoperatively unless the mass is subjected to histological and immunohistochemical analysis after tumor excision.
Downloads
Metrics
References
Moore SW, Satge D, Sasco AJ, Zimmermann A, Plaschkes J. The epidemiology of neonatal tumours. Pediatr Surg Int. 2003; 19:509-19.
Maris JM. Recent advances in neuroblastoma. New Eng J Med. 2010; 362:2202-11.
Avery GB. Avery's neonatology: pathophysiology & management of the newborn. Lippincott Williams & Wilkins; 2005:1235-73.
Park JR, Eggert A, Caron H. Neuroblastoma: biology, prognosis, and treatment. Hematology/oncology clinics of North America. 2010; 24:65-86.
Rosen EM, Cassady JR, Frantz CN, Kretschmar C, Levey R, Sallan SE. Neuroblastoma: the Joint Center for Radiation Therapy/Dana-Farber Cancer Institute/Children's Hospital experience. J Clin Oncol. 1984; 2:719-32.
Rothenberg AB, Berdon WE, D’Angio GJ, Yamashiro DJ, Cowles RA. Neuroblastoma—remembering the three physicians who described it a century ago: James Homer Wright, William Pepper, and Robert Hutchison. Pediatr Radiol. 2009; 39:155-60.
George TI. Malignant or benign leukocytosis. Hematology 2010, the American Society of Hematology Education Program Book. 2012; 2012:475-84.
Tsuchida Y, Ikeda H, Ihara T, Toyoda Y, Kawa K, Fukuzawa M. Neonatal neuroblastoma: incidence and clinical outcome. Med Pediatr Oncol. 2003; 40:391-3.
Leclair MD, Hartmann O, Heloury Y, Fourcade L, Laprie A, Mechinaud F, et al. Localized pelvic neuroblastoma: excellent survival and low morbidity with tailored therapy-the 10-year experience of the French Society of Pediatric Oncology. J Clinic Oncol. 2004; 22:1689-95.
Fatih SU, Bozkurter T, Murat EL, Tander B, Dagdemir A, Ceyhan M. A case of sacrococcygeal neuroblastoma. J Experim Clin Med. 2013; 30:75-7.
Halkes CJ, Dijstelbloem HM, Eelkman Rooda SJ, Kramer MH. Extreme leucocytosis: not always leukaemia. Neth J Med. 2007; 65:248-51.
Park JR, Eggert A, Caron H. Neuroblastoma: biology, prognosis, and treatment. Hematology/Oncology Clinics of North America. 2010; 24:65-86.
Tanaka K, Kanai M, Yosizawa J, Yamazaki Y. A case of neonatal neuroblastoma mimicking Altman type III sacrococcygeal teratoma. J Pediatr Surg. 2005; 40:578-80.
Watanabe M, Komuro H, Kaneko M, Hori T, Tatekawa Y, Kudo S, et al. A rare case of presacral cystic neuroblastoma in an infant. J Pediatr Surg. 2008; 43:1376-9.
Hawkes CP, Betts DR, John O, Maureen JO, Capra M. Congenital sacrococcygeal PNET and chemotherapy. Ind J Med Paediatr Oncol. 2012; 33:182-4.
Published
How to Cite
Issue
Section
License
Copyright (c) 2022 Obay A Edan, Nazar MT Jawhar
This work is licensed under a Creative Commons Attribution 4.0 International License.
You are free to:
- Share — copy and redistribute the material in any medium or format
- Adapt — remix, transform, and build upon the material for any purpose, even commercially.
Terms:
- Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
