Double meningomyelocele - a rare variant of neural tube defect: A case series
DOI:
https://doi.org/10.52783/jns.v11.1126Keywords:
Congenital, Embryogenesis, Meningomyelocele, SpineAbstract
Background: A neural tube defect is a common congenital malformation and it commonly presents as an isolated cystic swelling on the back, anywhere from occiput to sacrum. However, multiple neural tube defects are rare with less than 100 cases reported worldwide.
Case Presentation: We are reporting two cases of multiple neural tube defects that presented in the newborn period with a history of concurrent swellings along the midline on the back. They were evaluated with ultrasonography and the diagnosis of double meningomyelocele was confirmed. Subsequently, they were operated on, both the lesions were excised, and the defects were repaired simultaneously.
Conclusion: Double meningomyelocele is a rare form of neural tube defect. Due to its rarity, exact embryogenesis is not known and thus, there is a need for further study on its embryology.
Downloads
Metrics
References
Hans JTD, Martin L, Akira H. Clinical Neuroembryology: Development and developmental disorders of the human central nervous system. 2nd ed. Heidelberg: Springer; 2014.
Zaganjor I, Sekkarie A, Tsang BL, Williams J, Razzaghi H, Mulinare J, et al. Describing the prevalence of neural tube defects worldwide: A systematic literature review. PLoS ONE. 2016; 11:e0151586.
Ahmad FU, Mahapatra AK. Neural tube defects at separate sites: further evidence in support of multi-site closure of the neural tube in humans. Surgical Neurol. 2009; 71:353-6.
Deora H, Srinivas D, Shukla D, Devi BI, Mishra A, Beniwal M, et al. Multiple-site neural tube defects: embryogenesis with complete review of existing literature. Neurosurg Fo¬cus. 2019; 47:E18.
Rogers LM, Cordero AM, Pfeiffer CM, Hausman DB, Tsang BL, De‐Regil LM, et al. Global folate status in women of reproductive age: a systematic review with emphasis on methodological issues. Ann New York Acad Sci. 2018; 1431:35-57.
Copp AJ, Greene ND. Neural tube defects--disorders of neurulation and related embryonic processes. Wiley Interdiscip Rev Dev Biol. 2013; 2:213-27.
Van Allen MI, Kalousek DK, Chernoff GF, Juriloff D, Harris M, McGillivray BC, et al. Evidence for multi-site closure of the neural tube in humans. Am J Med Genet. 1993; 47:723–43.
Mahalik SK, Vaze D, Kanojia RP, Narasimhan KL, Rao KLN. Multiple neural tube defects may not be very rare. Childs Nerv Syst. 2013; 29:609–19.
Sarda D, Kothari P, Laddha A, Kulkarni B. Double meningomyelocele: Embryogenesis.J Pediatr Neurosci. 2007; 2:26-7.
Published
How to Cite
Issue
Section
License
Copyright (c) 2022 MD MOKARRAM ALI, Yogender Singh Kadian
This work is licensed under a Creative Commons Attribution 4.0 International License.
You are free to:
- Share — copy and redistribute the material in any medium or format
- Adapt — remix, transform, and build upon the material for any purpose, even commercially.
Terms:
- Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
