Early-Life Nutrition and Its Impact on Neurodevelopmental Outcomes in Preterm Infants
DOI:
https://doi.org/10.52783/jns.v14.1851Keywords:
Brain Development, Cognitive Outcomes, Early-Life Nutrition, Gut Microbiota, Micronutrient Deficiencies, NeurodevelopmentAbstract
Early-life nutrition plays a crucial role in the neurodevelopmental outcomes of preterm infants, significantly influencing brain growth and maturation. Preterm infants often encounter unique nutritional challenges due to their limited reserves and heightened energy requirements. Research indicates that higher intake of essential nutrients, including protein, energy, and long-chain polyunsaturated fatty acids (LCPUFAs), during the early postnatal period is associated with improved cognitive and developmental outcomes. Nutritional deficits in the initial weeks after birth can negatively impact neurodevelopment, potentially leading to long-lasting effects into childhood and adolescence. Furthermore, the intricate relationship between specific nutrients and neurodevelopment highlights the importance of tailored nutritional approaches, such as the fortification of human milk and targeted supplementation of micronutrients like iron and zinc. Recent studies also emphasize the role of human milk oligosaccharides in promoting a healthy gut microbiome, which is vital for neuroprotection and optimal brain development. Overall, the evidence strongly supports proactive nutritional interventions as a means to enhance neurodevelopmental outcomes in this vulnerable population, emphasizing that adequate early nutritional support can mitigate risks associated with preterm birth.
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Caspi, A., Williams, B., Kim-Cohen, J., Craig, I. W., Milne, B. J., Poulton, R., & Moffitt, T. E. (2007). Moderation of breastfeeding effects on the IQ by genetic variation in fatty acid metabolism. Proceedings of the National Academy of Sciences, 104(47), 18860-18865. https://doi.org/10.1073/pnas.0704292104
Der, G., Batty, G. D., & Deary, I. J. (2006). Effect of breast feeding on intelligence in children: Prospective study, sibling pairs analysis, and meta-analysis. BMJ, 333(7575), 945. https://doi.org/10.1136/bmj.38978.699583.55
Godfrey, K. M., & Barker, D. J. P. (2001). Fetal programming and adult health. Public Health Nutrition, 4(2B), 611-624. https://doi.org/10.1079/PHN2001145
Hsiao, E. Y., McBride, S. W., Hsien, S., Sharon, G., Hyde, E. R., McCue, T., & Mazmanian, S. K. (2014). The microbiota modulates gut physiology and immune function. Cell, 159(5), 1029-1041. https://doi.org/10.1016/j.cell.2014.10.043
Isaacs, E. B., Gadian, D. G., Sabatini, S., Chong, W. K., Quinn, B. T., Fischl, B., & Lucas, A. (2008). The effect of early human diet on caudate volumes and IQ. Pediatric Research, 63(3), 308-314. https://doi.org/10.1203/PDR.0b013e318163a271
Kramer, M. S., Aboud, F., Mironova, E., Vanilovich, I., Platt, R. W., Matush, L., ... & Shapiro, S. (2008). Breastfeeding and child cognitive development: New evidence from a large randomized trial. Archives of General Psychiatry, 65(5), 578-584. https://doi.org/10.1001/archpsyc.65.5.578
Lucas, A., Morley, R., & Cole, T. J. (1998). Randomized trial of early diet in preterm babies and later intelligence quotient. BMJ, 317(7171), 1481-1487. https://doi.org/10.1136/bmj.317.7171.1481
Mortensen, E. L., Michaelsen, K. F., Sanders, S. A., & Reinisch, J. M. (2002). The association between duration of breastfeeding and adult intelligence. JAMA, 287(18), 2365-2371. https://doi.org/10.1001/jama.287.18.2365
Morgane, P. J., Austin-LaFrance, R., Bronzino, J., Tonkiss, J., Díaz-Cintra, S., Cintra, L., ... & Galler, J. R. (1993). Prenatal malnutrition and development of the brain. Neuroscience & Biobehavioral Reviews, 17(1), 91-128. https://doi.org/10.1016/S0149-7634(05)80231-9
Shenkin, S. D., Starr, J. M., & Deary, I. J. (2004). Birth weight and cognitive ability in childhood: A systematic review. Psychological Bulletin, 130(6), 989-1013. https://doi.org/10.1037/0033-2909.130.6.989
Slykerman, R. F., Thompson, J. M., Waldie, K. E., Becroft, D. M., Robinson, E., Pryor, J. E., ... & Mitchell, E. A. (2005). Breastfeeding and intelligence of preschool children. Acta Paediatrica, 94(7), 832-837. https://doi.org/10.1111/j.1651-2227.2005.tb01982.x
Steer, C. D., Davey Smith, G., Emmett, P. M., Hibbeln, J. R., & Golding, J. (2010). FADS2 polymorphisms modify the effect of breastfeeding on child IQ. Pediatrics, 126(1), e137-e145. https://doi.org/10.1542/peds.2009-1580
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