Comparative Study Between Sentinel Node Biopsy Versus Axillary Sampling in Women with Clinically Node Negative Operable Breast Cancer
DOI:
https://doi.org/10.52783/jns.v14.1881Keywords:
Node negative breast cancer, sentinel lymph node biopsy, low axillary sampling, validityAbstract
Background and Objectives- More recent advance in the field of breast cancer detection at early stage is axillary lymph node sampling, which involves sampling of few lymph nodes removed from axilla for detecting cancerous cells. The aim is to compare the methodologies between sentinel lymph node biopsy and low axillary sampling in predicting status of axillary lymph nodes in clinically node negative operable breast cancer patients.
Methodology: A prospective longitudinal study was conducted among 50 breast cancer operable patients with clinically node negative. Axillary sampling was performed first by making a 2 cm incision in the middle third of the proposed axillary clearance incision below the axillary hairline. All axillary fat and tissue in an area of 2cm diameter was dissected out.
Results- LAS has a sensitivity of 97.5%, which means it would be able to detect the true positives in 97.5% of the patients and the ability to detect true negatives (specificity) is 64.5%. Similarly, the positive predictive value and the negative predictive value is 91.5% and 89.7% respectively with an accuracy rate of 90%.
Conclusion- The results of this study indicate that Sentinel node biopsy and Low axillary sampling are equally accurate. Given the resource and equipment constraints, especially with respect to nuclear medicine facilities, LAS could be the preferred technique in developing countries.
Downloads
Metrics
References
Sivridis E, Giatromanolaki A, Galazios G, Koukourakis MI. Node related factors and survival in node-positive breast carcinomas. Breast 2006;15:382-9.
Crabb SJ, Cheang MC, Leung S, Immonen T, Nielsen TO, Huntsman DD, et al. Basal breast cancer molecular subtype predicts for lower incidence of axillary lymph node metastases in primary breast cancer. Clin Breast Cancer 2008;8:249-56.
] Naik AM, Fey J, Gemignani M, et al. The risk of axillary relapse after sentinel node biopsy for breast cancer is comparable with that of axillary lymph node dissection. A follow-up study of 4008 procedures. Ann Surg 2004;240(3): 462e71.
Veronesi U, Galimberti V, Mariani L, et al. Sentinel node biopsy in breast cancer: early results in 953 patients with negative sentinel node biopsy and no axillary dissection. Eur J Cancer 2005;41:231e7.
Krag DN, Anderson SJ, Julian TB. Sentinel-lymph-node resection compared with conventional axillary-lymph-node dissection in clinically node-negative patients with breast cancer: overall survival findings from the NSABP B-32 randomised phase 3 trial. Lancet Oncol 2010 Oct;11(10):927e33.
Veronesi U, Galimberti V, Paganelli G, et al. Axillary metastases in breast cancer patients with negative sentinel nodes: a follow up of 3548 cases. Eur J Cancer 2009;45:1381e8.
van der Ploeg IM, Nieweg OE, van Rijk MC, Olmos RA Valdes, Kroon BB. Axillary recurrence after a tumour-negative sentinel node biopsy in breast cancer patients: A systematic review and meta-analysis of the literature. Eur J Surg Oncol. 2008;34:1277–84.
Fisher B, Bauer M, Margolese R, et al. Five-year results of a randomized clinical trial comparing total mastectomy and segmental mastectomy with or without radiation in the treatment of breast cancer. N Engl J Med. 1985;312:665–73.)
V. Parmar, R. Hawaldar, N.S. Nair, T. Shet etal. Sentinel node biopsy versus low axillary sampling in women with clinically node negative operable breast cancer. The Breast 22 (2013) 1081e1086
Kim T, Giuliano AE, Lyman GH. Lymphatic mapping and sentinel lymph node biopsy in early-stage breast carcinoma. A metaanalysis. Cancer 1 Jan 2006;106(1):4e16.
MacMillan RD, Barbera D, Hadjiminas DJ, et al. Sentinel node biopsy for breast cancer may have little to offer four-node-samplers: results of a prospective comparison study. Eur J Cancer 2001;37:1076e80.
Fisher ER, Swamidoss S, Lee CH, Rockette H, Redmond C, Fisher B. Detection and significance of occult axillary node metastases in patients with invasive breast cancer. Cancer 1978 Oct;42(4):2025e31.
Cserni G. The reliability of sampling three to six nodes for staging breast cancer. J Clin Pathol 1999;52:681e3.
Giuliano AE, Jones RE, Brennan M, Statman R. Sentinel lymphadenectomy in breast cancer. J Clin Oncol. 1997;15: 2345–2350.
Horgan K, Mancie-Jones B, Mada M, Andrew A, Quinn C. Axillary sentinel node identification in breast cancer with dye injection alone. Br J Surg. 1998;85(Suppl 1):51–52.
Downloads
Published
How to Cite
Issue
Section
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
You are free to:
- Share — copy and redistribute the material in any medium or format
- Adapt — remix, transform, and build upon the material for any purpose, even commercially.
Terms:
- Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
