Canine Bone Repair and The Effects of Urinary Bladder Submucosa Implants
DOI:
https://doi.org/10.52783/jns.v14.1921Keywords:
Canine bone repair, urinary bladder, submucosaAbstract
From the local strain, twenty adult male dogs were chosen. Two groups were formed from the dogs: the control group and the treatment group. To put the dogs to sleep, the anesthesiologists used a mix of xylazine and ketamine, with a dosage of 5 mg/kg of body weight for each. An electric drill was used to produce an 8 mm diameter hole in the distal part of the tibia in the control group. In the first week after surgery, the clinical results showed that edema, pain, and increased temperature at the operative site were more prominent in the treatment group compared to the control group, indicating inflammation. The treatment group reported a resolution of inflammatory symptoms four to five days after treatment, while the control group reported a resolution within six to seven days. According to the results of the radiographs, the sham response began in the first week of the trial for the treatment group but did not begin until the end of the third week for the control group. By the end of the third week of treatment, the control group no longer saw the line at all. By week four, the treatment group had witnessed the platelet bone re-establishing the bone bridge. When this happened, the contouring bones were restored because the outer callus merged with the bone. This study found that the healing of fractures was of higher quality and quantity in the treatment group compared to the control group. The treated group exhibited a significant increase in the growth and activity of osteoblasts, osteoclasts, and periosteal responses at the 15th and 30th days after the surgery. Additionally, there was a higher occurrence of osteocytes in the treated group compared to the control group
Downloads
Metrics
References
MacKenzie EJ, Jones AS, Bosse MJ, et al. Health-care costs associated with amputation or reconstruction of a limb-threatening injury. J Bone Joint Surg Am 2007;89:1685–92.
Urquhart DM, Edwards ER, Graves SE, et al. Characterisation of orthopaedic trauma admitted to adult Level 1 Trauma Centres. Injury 2006;37:120–7.
Bradley C, Harrison J. Descriptive epidemiology of traumatic fractures in Australia. Injury research and statistics series. Adelaide: Australian Institute of Health and Welfare, 2004.
Court-Brown CM, Rimmer S, Prakash U, et al. The epidemiology of open long bone fractures. Injury 1998;29:529–34 and Milar et al.,2015
Millar, I. L., McGinnes, R. A., Williamson, O., Lind, F., Jansson, K. Å., Hajek, M. & Cameron, P. (2015). Hyperbaric Oxygen in Lower Limb Trauma (HOLLT); protocol for a randomised controlled trial. BMJ open, 5(6): 23-26.
MacKenzie EJ, Jones AS, Bosse MJ. (2007). Health-care costs associated with amputation or reconstruction of a limb-threatening injury. J Bone Joint Surg Am. 89(12):1685–1692.
Urquhart DM, Edwards ER, Graves SE. (2006). Characterisation of orthopaedic trauma admitted to adult Level 1 Trauma Centres. Injury. 37:120-127.
Badylak, S. F., Voytik, S. L., Brightman, A., &Waninger, M. (2016). U.S. Patent No. 5,554,389. Washington, DC: U.S. Patent and Trademark Office. Matheny, R. G. (). U.S. Patent Application No. 14/452,707.
Hodde, J. P., Badylak, S. F., and Shelbourne, K. D. (1997). The effect of range of motion on remodeling of small intestinal submucosa (SIS) when used as an Achilles tendon repair material in the rabbit. Tissue engineering. 3(1);27-37.
Eberli, D.; Atala, A. and Yoo, J.J. (2011). One and four layer acellular bladder matrix for fascial tissue reconstruction. J. Mater Sci. Mater Med. 22:741-751.
Pharaon, S. K., Schoch, S., Marchand, L., Mirza, A., and Mayberry, J. (2018). Orthopaedic traumatology: fundamental principles and current controversies for the acute care surgeon. Trauma Surgery & Acute Care Open. 3(1):110-117.
Matheny, R. (2007). Compositions for reconstruction, replacement or repair of intracardiac tissue. U.S. Patent Application. 6(11):324,331.
Fiamingo, A., Montembault, A., Boitard, S. E., Naemetalla, H., Agbulut, O., Delair, T., and David, L. (2016). Chitosan hydrogels for the regeneration of infarcted myocardium: preparation, physicochemical characterization, and biological evaluation. Biomacromolecules. 17(5): 1662-1672.
Wraighte, P. J., &Scammell, B. E. (2006). Principles of fracture healing. Surgery-Oxford International Edition. 24(6): 198-207.
Dallas, S. L., Prideaux, M., & Bonewald, L. F. (2013). The osteocyte: an endocrine cell and more. Endocrine reviews. 34(5): 658-690.
Bartl, R., & Bartl, C. (2016). Bone Disorders: Biology, Diagnosis, Prevention, Therapy. Springer.11(3):113-119.
Kalfas, I. H. (2001). Principles of bone healing. Neurosurgical focus, 10(4), 1-4.
Loi, F., Cordova, L. A., Pajarinen, J., Lin, T. H., Yao, Z., and Goodman, S. B. (2016). Inflammation, fracture and bone repair Bone. 86:119-130.
Boddupalli, A., Zhu, L., and Bratlie, K. M. (2016). Methods for Implant Acceptance and Wound Healing: Material Selection and Implant Location Modulate Macrophage and Fibroblast Phenotypes. Advanced healthcare materials. 5(20): 2575-2594.
Noviana, D., Soedjono, G., Abdullah, D., Soehartono, R. H., Ulum, M. F., Siswandi, R., & Dahlan, K. A. (2011). In vivo study of hydroxyapatite-chitosan and hydroxyapatite-tricalcium phosphate bone graft in sheep's bone as animal model. In Instrumentation, Communications, Information Technology, and Biomedical Engineering (ICICI-BME), 2011 2nd International Conference on Pp. 403-408.
Hyytiainen, H. (2016). Small animal treatment and rehabilitation for neurological conditions. Animal Physiotherapy: Assessment, Treatment and Rehabilitation of Animals. 23(5): 260.
Halper, J., and Kjaer, M. (2014). Basic components of connective tissues and extracellular matrix: elastin, fibrillin, fibulins, fibrinogen, fibronectin, laminin, tenascins and thrombospondins. In Progress in Heritable Soft Connective Tissue Diseases (pp. 31-47). Springer, Dordrecht.
Wierer, M., Prestel, M., Schiller, H. B., Yan, G., Schaab, C., Azghandi, S.&Aherrahrou, Z. (2018). Compartment-resolved Proteomic Analysis of Mouse Aorta during Atherosclerotic Plaque Formation Reveals Osteoclast-specific Protein Expression. Molecular & Cellular Proteomics. 17(2): 321-334.
Kim, E. J., Choi, J. S., Kim, J. S., Choi, Y. C., & Cho, Y. W. (2015). Injectable and thermosensitive soluble extracellular matrix and methylcellulose hydrogels for stem cell delivery in skin wounds. Biomacromolecules. 17(1): 4-11.
Xing, Q., Qian, Z., Jia, W., Ghosh, A., Tahtinen, M., & Zhao, F. (2016). Natural extracellular matrix for cellular and tissue biomanufacturing. ACS Biomaterials Science & Engineering. 3(8):1462-1476.
Mistry, A. S., and Mikos, A. G. (2005). Tissue engineering strategies for bone regeneration. In Regenerative medicine II . Springer Berlin Heidelberg. Pp. 1-22.
Liu, W. C., Chen, S., Zheng, L., and Qin, L. (2017). Angiogenesis Assays for the Evaluation of Angiogenic Properties of Orthopaedic Biomaterials–A General Review. Advanced Healthcare Materials. 12(3):123-128.
Eliaz, N., and Metoki, N. (2017). Calcium Phosphate Bioceramics: A Review of Their History, Structure, Properties, Coating Technologies and Biomedical Applications. Materials. 10(4): 334.
Downloads
Published
How to Cite
Issue
Section
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
You are free to:
- Share — copy and redistribute the material in any medium or format
- Adapt — remix, transform, and build upon the material for any purpose, even commercially.
Terms:
- Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
