Symptomatic and Asymptomatic Rotavirus Infections Among Urban Population of Early Childhood: A Cross-Sectional Study
DOI:
https://doi.org/10.52783/jns.v14.1938Keywords:
Rotavirus, prevalence, diarrhea, symptomatic, asymptomatic, vaccineAbstract
The infections caused by rotavirus are given paramount attention worldwide as they are often implicated with significant morbidity and mortality of childhood population. The present study attempted to explore the prevalence of symptomatic and asymptomatic rotavirus infections among the children dwelling from Chennai city, India. Two hundred children below the age of 5, belonging to two categories, were screened for the rotavirus infection by means of detection of viral antigen from stool samples by Enzyme Linked Immunosorbent Assay. The overall prevalence of rotavirus infection was 34% which encompassed 53.3% and 22.4% symptomatic and asymptomatic cases. Within the symptomatic subjects, 48.7% and 58.3% of male and female children were positive for the infection. The rates of positivity to the viral infection among the male and female asymptomatic cases respectively were 25.9% and 19.4%. Attributable sociodemographic and medical factors identified for rotavirus infection among the symptomatic and asymptomatic cases respectively were, domicile of low scale area (77.5 and 71.4%), low education level of parents (80.0 and 60.7%) and lack of vaccination (92.5 and 82.1%). Breast feeding showed better protective impact on symptomatic cases (47.5) than the asymptomatic cases (32.1%). Need for further investigations on virus strains implicated with asymptomatic infections and vaccine failure has been suggested for ensuring sustainable public health of young population.
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Parikh, R., Raju, B., Vetter, V., & Kolhapure, S. (2019). Epidemiology of rotavirus gastroenteritis and need of high rotavirus vaccine coverage with early completion of vaccination schedule for protection against rotavirus diarrhea in India: A narrative review. Indian Journal of Public Health, 63(3), 243-250. https://doi.org/10.4103/ijph.ijph_307_18
Habib, F. B., Rahman, M. M., Haque, M. M., Sinha, S. P., Dey, S., Tanni, N. N., Nabi, M. A. U., Jhuma, A. A., & Hasan, M. N. (2021). A Comparative Study of Rotaviral Antigen Detection by ELISA and ICT in Children below Five Years with Acute Diarrhoea in A Tertiary Care Hospital. Bangladesh Medical Journal, 49(1), 14–18. https://doi.org/10.3329/bmj.v49i1.52584
Orhan, Z., Mohamud, S., Mohamud, R., & Doğan, S. (2024). Rotavirus Prevalence in Children with Acute Gastroenteritis Admitted to a Tertiary Hospital in Somalia in 2020-2023: A Retrospective, Single-Center Study. Pediatric Health, Medicine and Therapeutics, Volume 15, 365–373. https://doi.org/10.2147/phmt.s475345
Saxena, K., Blutt, S. E., Ettayebi, K., Zeng, X.-L., Broughman, J. R., Crawford, S. E., Karandikar, U. C., Sastri, N. P., Conner, M. E., Opekun, A. R., Graham, D. Y., Qureshi, W., Sherman, V., Foulke-Abel, J., In, J., Kovbasnjuk, O., Zachos, N. C., Donowitz, M., & Estes, M. K. (2016). Human Intestinal Enteroids: a New Model To Study Human Rotavirus Infection, Host Restriction, and Pathophysiology. Journal of Virology, 90(1), 43–56. https://doi.org/10.1128/jvi.01930-15
Lakshminarayanan, S., & Jayalakshmy, R. (2015). Diarrheal diseases among children in India: Current scenario and future perspectives. Journal of Natural Science, Biology and Medicine, 6(1), 24. https://doi.org/10.4103/0976-9668.149073
Mohan, V. R., Karthikeyan, R., Babji, S., McGrath, M., Shrestha, S., Shrestha, J., Mdumah, E., Amour, C., Samie, A., Nyathi, E., Haque, R., Qureshi, S., Yori, P. P., Lima, A. A. M., Bodhidatta, L., Svensen, E., Bessong, P., Ahmed, T., … Seidman, J. C. (2017). Rotavirus Infection and Disease in a Multisite Birth Cohort: Results From the MAL-ED Study. The Journal of Infectious Diseases, 216(3), 305–316. https://doi.org/10.1093/infdis/jix199
Maheshwari, A., Shakya, P., Adhikari, B., Nepal, A. S., & Pandey, P. (2022). Rotavirus Infection in Neonates and Young Infants. Newborn, 1(1), 142–150. https://doi.org/10.5005/jp-journals-11002-0014
Dóró, R., Farkas, S. L., Martella, V., & Bányai, K. (2015). Zoonotic transmission of rotavirus: surveillance and control. Expert Review of Anti-Infective Therapy, 13(11), 1337–1350. https://doi.org/10.1586/14787210.2015.1089171
Malik, Y. S., Bhat, S., Dar, P. S., Sircar, S., Dhama, K., & Singh, R. K. (2020). Evolving Rotaviruses, Interspecies Transmission and Zoonoses. The Open Virology Journal, 14(1), 1–6. https://doi.org/10.2174/1874357902014010001
Flores, P. S., Costa, F. B., Amorim, A. R., Mendes, G. S., Rojas, M., & Santos, N. (2020). Rotavirus A, C, and H in Brazilian pigs: potential for zoonotic transmission of RVA. Journal of Veterinary Diagnostic Investigation, 33(1), 129–135. https://doi.org/10.1177/1040638720967673
Memon, A. M., Chen, F., Khan, S. B., Guo, X., Khan, R., Khan, F. A., Zhu, Y., & He, Q. (2022). Development and evaluation of polyclonal antibodies based antigen capture ELISA for detection of porcine rotavirus. Animal Biotechnology, 34(5), 1807–1814. https://doi.org/10.1080/10495398.2022.2052304
Okoh, J. C., Ogbonna, I. O., & Shitta, N. N. (2019). Detection of Rotavirus Vp6 Antigen in Faeces of Asymptomatic School-Aged Pupils in Gboko, Benue State of Nigeria. International Journal of Research and Scientific Innovation (IJRSI); VI(XII).
Lee, B., Kader, M. A., Alam, M., Dickson, D. M., Harvey, P., Colgate, E. R., Taniuchi, M., Petri, W. A., Haque, R., & Kirkpatrick, B. D. (2024). Infant Non-Secretor Histoblood Group Antigen Phenotype Reduces Susceptibility to Both Symptomatic and Asymptomatic Rotavirus Infection. Pathogens, 13(3), 223. https://doi.org/10.3390/pathogens13030223
Oluwaseun, S., Cagnan, L., Xausa, I., Nachbar, R. B., Levy Bachelot, L., Chen, Y.-H., & Carias, C. (2024). Projected Public Health Impact of a Universal Rotavirus Vaccination Program in France. Pediatric Infectious Disease Journal, 43(9), 902–908. https://doi.org/10.1097/inf.0000000000004448
Lopman, B. A., Pitzer, V. E., Sarkar, R., Gladstone, B., Patel, M., Glasser, J., Gambhir, M., Atchison, C., Grenfell, B. T., Edmunds, W. J., Kang, G., & Parashar, U. D. (2012). Understanding Reduced Rotavirus Vaccine Efficacy in Low Socio-Economic Settings. PLoS ONE, 7(8), e41720. https://doi.org/10.1371/journal.pone.0041720
Naylor, C., Lu, M., Haque, R., Mondal, D., Buonomo, E., Nayak, U., Mychaleckyj, J. C., Kirkpatrick, B., Colgate, R., Carmolli, M., Dickson, D., van der Klis, F., Weldon, W., Steven Oberste, M., Ma, J. Z., & Petri, W. A. (2015). Environmental Enteropathy, Oral Vaccine Failure and Growth Faltering in Infants in Bangladesh. EBioMedicine, 2(11), 1759–1766. https://doi.org/10.1016/j.ebiom.2015.09.036
Lee, B. (2020). Update on rotavirus vaccine underperformance in low- to middle-income countries and next-generation vaccines. Human Vaccines & Immunotherapeutics, 17(6), 1787–1802. https://doi.org/10.1080/21645515.2020.1844525
Pollock, L., Bennett, A., Jere, K. C., Mandolo, J., Dube, Q., Bar-Zeev, N., Heyderman, R. S., Cunliffe, N. A., & Iturriza-Gomara, M. (2022). Plasma Rotavirus-specific IgA and Risk of Rotavirus Vaccine Failure in Infants in Malawi. Clinical Infectious Diseases, 75(1), 41–46. https://doi.org/10.1093/cid/ciab895
Bagali, S., Kakhandaki, L., Karigoudar, R., Wavare, S., Shahapur, P. R., & Patil, M. M. (2023). Comparative Analysis of Enzyme-Linked Immunosorbent Assay and Immunochromatography for Rotavirus and Adenovirus Detection in Children below Five Years with Acute Gastroenteritis. Journal of Laboratory Physicians, 15(01), 110–116. CLOCKSS. https://doi.org/10.1055/s-0042-1757234
Kurugöl, Z., Ozkinay, F., Yaprak, I., Bak, M., Vardar, F., Erensoy, S., Vardar, F., & Ozkinay, C. (2003). Rotavirus gastroenteritis among children under five years of age in Izmir, Turkey. The Turkish journal of pediatrics, 45(4), 290-294.
Tasic, G., Stankovic-Djordjevic, D., Dinic, M., Miladinovic-Tasic, N., & Tasic, M. (2006). Rotavirus Infection in Infants and Young Children. Biotechnology & Biotechnological Equipment, 20(2), 141–145. https://doi.org/10.1080/13102818.2006.10817356
Barrón-Romero, B. L., Barreda-González, J., Doval-Ugalde, R., Zermeño-Eguia Liz, J., & Huerta-Peña, M. (1985). Asymptomatic rotavirus infections in day care centers. Journal of Clinical Microbiology, 22(1), 116–118. https://doi.org/10.1128/jcm.22.1.116-118.1985
Kazemi, A., Tabatabaie, F., Agha-Ghazvini, M. R., & Kelishadi, R. (2006). The role of rotavirus in acute pediatric diarrhea in Isfahan, Iran. Pakistan Journal of Medical Sciences, 22(3), 282-5.
Naranjo, A., Cedeño, C., Teran, E., & Castello, A. (2008). Prevalence of VP4 and VP7 genotypes of human rotavirus in Ecuadorian children with acute diarrhea. Journal of Medical Virology, 80(6), 1106–1111. Portico. https://doi.org/10.1002/jmv.21181
Ojobor, C. D., Olovo, C. V., Onah, L. O., & Ike, A. C. (2020). Prevalence and associated factors to rotavirus infection in children less than 5 years in Enugu State, Nigeria. VirusDisease, 31(3), 316–322. https://doi.org/10.1007/s13337-020-00614-x
Saravanan, P., Ananthan, S., & Ananthasubramanian, M. (2004). Rotavirus infection among infants and young children in Chennai, South India. Indian Journal of Medical Microbiology, 22(4), 212–221. https://doi.org/10.1016/s0255-0857(21)02765-1
Nyati, P., Choudhary, P., & Thora, S. (2019). Clinico-epidemiological profile of acute watery diarrhoea in under five children with special reference to rotavirus infection. Journal of Evolution of Medical and Dental Sciences, 8(14), 1141–1144. https://doi.org/10.14260/jemds/2019/253
Vethanayagam, R. R., Ananda Babu, M., Nagalaxmi, K. S., Maiya, P. P., Venkatesh, H. A., Purohit, S., Behl, R., Bhan, M. K., Ward, R. L., Greenberg, H. B., & Durga Rao, C. (2004). Possible Role of Neonatal Infection with the Asymptomatic Reassortant Rotavirus (RV) Strain I321 in the Decrease in Hospital Admissions for RV Diarrhea, Bangalore, India, 1988–1999. The Journal of Infectious Diseases, 189(12), 2282–2289. https://doi.org/10.1086/420889
Nasih, L. D., & Ali, K. S. (2023). The Frequency of Rotavirus Infection among Children under the age 5 years in Erbil Province, Kurdistan Region, Iraq, a hospital based study. Diyala Journal of Medicine, 24(1), 162–176. https://doi.org/10.26505/djm.v24i1.981
Dhiman, S., Devi, B., Singh, K., & Devi, P. (2015). Comparison of enzyme-linked immunosorbent assay and immunochromatography for rotavirus detection in children below five years with acute gastroenteritis. Journal of clinical and diagnostic research: JCDR, 9(9), DC06.
Paniker, C. K. J., Mathew, S., & Mathan, M. (1982). Rotavirus and acute diarrhoeal disease in children in a southern Indian coastal town. Bulletin of the World Health Organization, 60(1), 123.
Bishop, R. F., Unicomb, L. E., Soenarto, Y., Suwardji, H., Ristanto, & Barnes, G. L. (1989). Rotavirus serotypes causing acute diarrhoea in hospitalized children in Yogyakarta, Indonesia during 1978–1979. Archives of Virology, 107(3–4), 207–213. https://doi.org/10.1007/bf01317917
Bennett, A., Pollock, L., Bar-Zeev, N., Lewnard, J. A., Jere, K. C., Lopman, B., Iturriza-Gomara, M., Pitzer, V. E., & Cunliffe, N. A. (2021). Community transmission of rotavirus infection in a vaccinated population in Blantyre, Malawi: a prospective household cohort study. The Lancet Infectious Diseases, 21(5), 731–740. https://doi.org/10.1016/s1473-3099(20)30597-1
Malik, A., Haldar, P., Ray, A., Shet, A., Kapuria, B., Bhadana, S., Santosham, M., Ghosh, R. S., Steinglass, R., & Kumar, R. (2019). Introducing rotavirus vaccine in the Universal Immunization Programme in India: From evidence to policy to implementation. Vaccine, 37(39), 5817–5824. https://doi.org/10.1016/j.vaccine.2019.07.104
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