Comparison Between Dynamic Neuromuscular Stabilization Breathing Exercises and Pilates Exercises in Young Overweight Individuals with Activity-Related Breathlessness
DOI:
https://doi.org/10.52783/jns.v14.2191Keywords:
Tuberculosis,Genitourinary system, Rifamycin, 8-(morpholinomethyl, Antitubercular applicationAbstract
Background: Tuberculosis is an ancient scourge. It has plagued humankind throughout known history and human pre-history. Mycobacterium tuberculosis have killed more persons than any other microbial pathogen [1]. Although the thorax is most frequently involved, tuberculosis may involve any of a number of organ systems like the respiratory, cardiac, central nervous system, musculoskeletal, gastrointestinal, and genitourinary systems and timely diagnosis of the disease is paramount, since delayed treatment is associated with severe morbidity [2].Thus the antibacterial properties of Rifamycin, 8-(morpholinomethyl)-, a molecule with the chemical formula C42H56N2O13 and a molecular weight of 796.9 g/mol, are investigated in this work.
Methodology: Rifamycin, 8-(morpholinomethyl)- was obtained in solid powder form and chemically synthesized. It was then examined using the Hexa disc method for Mycobacterium tuberculosis. When the pathogen was inoculated over sterilized agar plates, different doses of Rifamycin, 8-(morpholinomethyl)- were administered. The inhibitory zones that evolved around the wells were measured in diameter. The outcome was contrasted with a positive control [3].
Results and Discussion: The study found that Rifamycin, 8-(morpholinomethyl)- had substantial antibiotic action against Mycobacterium , with inhibitory zones growing in size with increasing concentrations. The findings suggest that the chemical compound can be used in the treatment of tuberculosis.
Conclusion:This study highlights Rifamycin, 8-(morpholinomethyl)-'s potent antibacterial qualities, which make it a viable option for treating tuberculosis. The compound's metabolites outperform its positive control thus serve a significant part in their efficacy. This study creates opportunities for further research and antitubercular application development.
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HISTORICAL REVIEW The history of tuberculosis Thomas M. Daniel Center for Global Health and Diseases, Case Western Reserve University School of Medicine,10900 Euclid Avenue, Cleveland, OH 44106-7286, USA. https://doi.org/10.1016/j.rmed.2006.08.006
Tuberculosis: A Radiologic ReviewJoshua Burrill, Christopher J. Williams, Gillian Bain, Gabriel Conder, Andrew L. Hine, Rakesh R. Misra. https://doi.org/10.1148/rg.275065176
The study was carried out at Grasmicrobe Private Limited (GMPL), which was established in 2016 in the tranquil surroundings of Hyderabad, India's Geneme Valley. https://pharmabharath.com/company/grasmicrobe-private-limited.
https://pubchem.ncbi.nlm.nih.gov/compound/5382548
Activity against drug resistant-tuberculosis strains of plants used in Mexican traditional medicine to treat tuberculosis and other respiratory diseases María Del Rayo Camacho-Corona 1, Mónica A Ramírez-Cabrera, Omar González- Santiago, Elvira Garza González, Isidoro de Paz Palacios, Julieta Luna-Herrera. https://doi.org/10.1002/ptr.2269.
Hirsh AE, Tsolaki AG, DeRiemer K, Feldman MW, Small PM. Stable association between strains of Mycobacterium tuberculosis and their human host populations. Proc Natl Acad Sci USA 2004;101:4871-6.
News-medical.net [Internet]. History of Tuberculosis. Available from: http://www.news-medical.net/health/History-of-Tuberculosis.aspx[Last cited on 2010 Oct 15].
Sweden: The Nobel Prize in Physiology or Medicine 1905: Robert Koch; c2010 Available from: http://nobelprize. org/nobel_prizes/medicine/laureates/1905/koch.html[Last cited on 2010 Oct 15].
World Health Organization. Fact Sheet No.104: Tuberculosis. Geneva: WHO; 2010 Available from: http://www.who.int/mediacentre/factsheets/ fs104/en/print.html [Last cited on 2010 Oct 15].
World Health Organization. THE GLOBAL PLAN TO STOP TB 2006 2015: PART I Strategic directions. Geneva: WHO; 2006 Available from: http://www.searo.who.int/LinkFiles/TB_Day_Kit_The_Global_Plan_to_ Stop_TB_2006-2015.pdf [Last cited on 2010 Oct 15].
Montes, M.; Phillips, C. Nonreactive tuberculosis. Am. Rev. Tuberc. 1959, 79, 362–370. [CrossRef] [PubMed]
Tejal Dharmraj Ghutke, Rushabh Gajanan Kadam, Vineeth M (2023). Impact of Organic Additives on Enzymatic Antioxidant Activities in Lentinus edodes Shiitake Mushroom. Environmental Reports; an International Journal. DOI: https://doi.org/10.51470/ER.2023.5.1.13
S.Z. Li et al Investigations of stable penta-and hexa-coordinate polynuclear Zn (II) and Cd (II) complexes derived from a single-armed salamo-based ligand. J. Coord. Chem.(2023).
Bañuls, A.L.; Sanou, A.; Van Anh, N.T.; Godreuil, S. Mycobacterium tuberculosis: Ecology and evolution of a human bacterium. J. Med. Microbiol. 2015, 64, 1261–1269. [CrossRef]
X. WangBioinformatics of Human Proteomics. Translational bioinformatics. Series 3(2013)
Z. Gao et al.PDTD: a web-accessible protein database for drug target identification BMC Bioinformatics (2008)
H. Li et al.TarFisDock: a web server for identifying drug targets with docking approachNucleic Acids Res (2006)
D. Chatterjee The mycobacterial cell wall: structure, biosynthesis and sites of drug actionCurr Opin Chem Biol (1997)
C.P. Owens et al. The Mycobacterium tuberculosis secreted protein Rv0203 transfers heme to membrane proteins MmpL3 and MmpL11 Biol Chem(2013)
V. Law et al. DrugBank 4.0: shedding new light on drug metabolism Nucleic Acids Res (2014)
Dakh, K.S.; Patekar, R.R.; Choudhary, H.B.; Momin, A.Z.; Undale, V.R.; Mahadik, P.; Desai, S.; Asalkar, M.; Shaikh, H. Herbal approach for tuberculosis management: A systematic review. World J. Adv. Res. Rev. 2022, 14, 637–647. [CrossRef]
S.G. Franzblau et al.Rapid, low technology MIC determination with clinical Mycobacterium tuberculosis isolates by using the microplateAlamar Blue assay. J. Clin. Microbiol.(1998).
Mosavari N., Karimi A., Tadayon K., Shahhosseini G., Zavaran Hosseini A., Babaie M. (2021). Evaluation of heating and irradiation methods for production of purified protein derivative (PPD) of Mycobacterium Tuberculosis. Arch. Razi. Inst. 75 439–449. 10.22092/ari.2019.123082.1238
Semenya, S.S.; Maroyi, A. Medicinal plants used for the treatment of tuberculosis by Bapedi traditional healers in three districts of the Limpopo Province, South Africa. AJTCAM 2013, 10, 316–323. [CrossRef]
Xu,Y.; Liang, B.; Kong, C.; Sun, Z. Traditional Medicinal Plants as a Source of Antituberculosis Drugs: A System Review. BioMed Res. Int. 2021, 2021, 9910365. [CrossRef] [PubMed]
Ghebreyesus T. A. and Lima N. T., The TB vaccine accelerator council: harnessing the power of vaccines to end the tuberculosis epidemic, The Lancet Infectious Diseases. (2023) 23, no. 11, 1222–1223, https://doi.org/10.1016/S1473-3099(23)00589-3, 37742697.[PubMed] [Google Scholar]
World Health Organization (WHO). https://www.who.int › tb-reportsGlobal Tuberculosis Report 2024.
[Development of antituberculous drugs: current status and future prospects] [Article in Japanese]Haruaki Tomioka 1, Kenji Namba
J. Hughes, P. Isaakidis, A. Andries, H. Mansoor, V. Cox, G. Meintjes, et al. Linezolid for multidrug-resistant tuberculosis in HIV-infected and -uninfected patients. Eur Respir J, 46 (2015), pp. 271-274 .http://dx.doi.org/10.1183/09031936.00188114 | Medline.
Essra Ali Safdar and Nida Ali Safdar (2025). Cross-sectional Retrospective Study on Prescription Pattern of Antihypertensive Medication in Pregnant Women with Gestational Hypertension. Journal of American Medical Science and Research. DOI: https://doi.org/10.51470/AMSR.2025.04.01.01
Lippia javanica (Burm.f.) Spreng.: Traditional and Commercial Uses and Phytochemical and Pharmacological Significance in the African and Indian Subcontinent Alfred Maroyi 1, doi: 10.1155/2017/6746071
Nida Ali Safdar, Soha Jabeen and Essra Ali Safdar (2024). Pelvic Congestion Syndrome: Etiology, Symptoms, and Epidemiology of a Chronic Pelvic Pain Disorder. Acta Pharma Reports. DOI: https://doi.org/10.51470/APR.2024.03.01.20
Essra Ali Safdar and Nida Ali Safdar (2024). Pantoprazole induced angioedema - A Case Report. Journal of American Medical Science and Research. DOI: https://doi.org/10.51470/AMSR.2024.03.02.15
Essra Ali Safdar and Nida Ali Safdar (2024). Bobblehead Syndrome- A Systematic Review. Journal of American Medical Science and Research. DOI: https://doi.org/10.51470/AMSR.2024.03.02.23
Essra Ali Safdar and Nida Ali Safdar (2024). Mermaid Syndrome- A Systematic Review. Journal of American Medical Science and Research. DOI: https://doi.org/10.51470/AMSR.2024.03.02.25
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