Overview on Current food Drug Interactions
DOI:
https://doi.org/10.52783/jns.v14.2233Keywords:
food, drug, nutrients, interactionAbstract
Although it is well known and identified that drug-drug interactions exist, the recognition of importance of food and drug interactions to practice has been growing much slower. On the other hand, drug-food/nutri- ent interactions continue to grow with the common use of medications. Beside the awareness of this type of interactions, food-drug interaction studies are critical to evaluate appropriate dosing, timing, and formulation of new drug candidates. Drug-food interactions take place mechanistically due to altered intestinal transport and metabolism, or systemic distribution, metabolism and excretion. In addition, some people have greater risk of food and drug interactions who have a poor diet, have serious health problems, children’s and pregnant women. In this article, basic information’s about importance, classifications, transporters and enzymes of drug and nutrient interaction are given and some specific examples of both drug and nutrients and influences on each other are included.
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References
Avoiding drug interactions, 2013. [online], http://www. fda.gov/downloads/ForConsumers/ConsumerUpdates/ ucm096391.pdf [access: May 2013].
Auer J., 2004. Cardiovascular drugs. Handbook of drug in- teractions a clinical and forensic guide. Ed. A. Mozaya- ni, P.L. ve Raymon. Humana New York, 219-292.
Bobroff B.L., Lentz A., Turner E.R., 2009. Food/drug and drug/nutrient interactions: what you should know about your medications. Univ. Florida IFAS Extens., FCS8092, 1-10.
Boullata J.I., 2010. An introduction to drug-nutrient inter- actions. Handbook of drug-nutrient interactions. Ed.
J.I. Boullata, V.T. Armenti. Humana New York, 3-25.
Boullata J.I., 2010. Drug disposition in obesity and protein-energy malnutrition. Proc. Nutr. Soc. 69, 543-550.
Boullata J.I., Hudson M.L., 2012. Drug-nutrient interac- tions: A broad view with implications for practise. Acad. Nutr. Diet. 112, 4, 506-517.
Braun L., 2012. An introduction to: drug-nutrient interac- tions. IMER Meet March, Monash Univ., 1-41.
Bushra R., Aslam N., Khan Y.A., 2011. Food-drug interac- tions. Oman Med. J. 26 (2), 77-83.
Custodio M.J., Wu C.Y., Benet Z.L., 2008. Predicting drug disposition, absorption/elimination/transporter interplay and the role of food on drug absorption. Adv. Drug Del. Rev. 60, 717-733.
FDA, 2013. Avoid food-drug interactions. A guide from the National Consumer League and U.S. Food Admin- istration Avoid Food-Drug Interactions. [online], http:// www.fda.gov/downloads/Drugs/ResourcesForYou/ Consumers/BuyingUsingMedicineSafely/EnsuringSa- feUseofMedicine/GeneralUseofMedicine/UCM229033. pdf [access: May 2013].
Fragoso R.L., Esparza R.J., 2013. Fruit/vegetable-drug in- teractions: Effects on drug metabolizing enzymes and drug transporters. Intech, 1-34.
Frankel H.E., 2003. Drug interactions: Basic concepts. In: Handbook of food-drug interactions. Eds J.B. McCabe, H.E. Frankel, J.J. Wolfe. CRC Boca Raton, 37-45. Lourenço L., 2001. Enteral feeding: Drug/nutrient interaction. Clin. Nutr. 20 (2), 187-193.
McCabe J.B., Frankel H.E., Wolfe J.J., 2003. Monitor- ing nutritional status in drug regimens. Handbook of food-drug interactions. Eds J.B. McCabe, H.E. Frankel,
J.J. Wolfe. CRC Boca Raton, 89-121.
Moss M., 2007. Drugs as anti-nutrients. J. Nutr. Environ. Med. 16 (2), 149-166.
Mukherjee K.P., Ponnusankar S., Pandit S., Hazam K.P., Ahmmed M., Mukherjee K., 2011. Botanicals as me- dicinal food and their effects on drug metabolizing en- zymes. Food Chem. Toxicol. 49, 3142-3153.
Robinson N.G., 2007. Herbs and foods that alter drug me- tabolism. [online], http://csuvets.colostate.edu/pain/ar- ticlespdf/herbs%20and%20foods%20that%20alter%20 drug%20metabolism.pdf [access: May 2013].
Scheen J.A., 2007. Diabetes, obesty and metabolic syn- drome. In: Nutrient-drug interactions. Ed. A.K. Meck- ling. CRC Taylor and Francis Boca Raton, 5-17.
Tamer C.E., Karaman B., 2006. Greyfurt Suyu ve İlaçlarla Etkileşimi. GIDA 31 (2), 101-106.
Wallace J.M., Gerencser M., Surley P., 2013. Drug-nu- trient depletions and known interactions. Nutritional Solutions. [online], www.nutritional-solutions.net [ac- cess: 2013].
Wunderlich M.S., 2004. Food and drug interactions. Hand- book of drug interactions. A clinical and forensic guide. Eds Ed. A. Mozayani, P.L. Raymon. Humana Press, 379-393.
Yaheya M., Ismail M., 2009. Drug-Food Interactions and Role of Pharmacist. Asian J. Pharm. Clin. Res. 2, 4, 1-10.
Yao T.H., Luo N.M., Hung L.B., Chiang T.M., Lin H.J., Lii K.C., Huang C.Y., 2012. Effects of chitosan oligosac- charides on drug-metabolizing enzymes in rat liver and kidneys. Food Chem. Toxicol. 50, 1171-1177.
Zyl V.M., 2011. The effects of drugs on nutrition. S. Afr. J. Clin. Nutr. 24 (3), 38-41.
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