To Assess and Evaluate the Characterisation of Gelatin as A Material of Choice for Membrane Adhesive
DOI:
https://doi.org/10.52783/jns.v14.2271Keywords:
Tissue adhesive, Cyanoacrylate adhesive, Bisphenol A-glycidyl methacrylate (Bis-GMA), gelatinAbstract
The current study aims to develop a novel tissue adhesive glue incorporating synthetic and semisynthetic material. The tissue glue is fabricated by incorporating bisphenol A-glycidyl methacrylate (Bis-GMA), gelatin methacrylate and methacrylic acid. The tissue adhesive was then tested for compressive strength, swelling behaviour and compatibility. The fabricated tissue adhesive exhibited compressive strength of 16.14 MPa and swelling behavior 3.69% at 3 hours. The biocompatibility of the material was 85.3% when treated against dental pulp stem cells. We conclude that gelatin-based hydrogels can be used as an alternative to conventional tissue adhesives.
Downloads
Metrics
References
Afewerki, Samson, Amir Sheikhi, Soundarapandian Kannan, Samad Ahadian, and Ali Khademhosseini. 2019. “Gelatin-Polysaccharide Composite Scaffolds for 3D Cell Culture and Tissue Engineering: Towards Natural Therapeutics.” Bioengineering & Translational Medicine 4 (1): 96–115.
Alshangiti, Dalal Mohamed, Tasneam K. El-damhougy, Ahmed Zaher, Mohamed Madani, and Mohamed Mohamady Ghobashy. 2023a. “Revolutionizing Biomedicine: Advancements, Applications, and Prospects of Nanocomposite Macromolecular Carbohydrate-Based Hydrogel Biomaterials: A Review.” RSC Advances 13 (50): 35251–91.
2023b. “Revolutionizing Biomedicine: Advancements, Applications, and Prospects of Nanocomposite Macromolecular Carbohydrate-Based Hydrogel Biomaterials: A Review.” RSC Advances 13 (50): 35251–91.
Bilgili, Hatice Kubra, Mehmet Serhat Aydin, Mervenaz Sahin, Sevilay Burcu Sahin, Sibel Cetinel, and Gullu Kiziltas. 2025. “3D-Printed Functionally Graded PCL-HA Scaffolds with Multi-Scale Porosity.” ACS Omega 10 (7): 6502–19.
Forooshani, Pegah Kord, Fatemeh Razaviamri, Ariana Smies, Lea M. Morath, Rattapol Pinnaratip, Md Saleh Akram Bhuiyan, Rupak Rajachar, Jeremy Goldman, and Bruce P. Lee. 2025. “Accelerated Dermal Wound Healing in Diabetic Mice by a HO-Generating Catechol-Functionalized Gelatin Microgel.” Journal of Materials Chemistry. B, March. https://doi.org/10.1039/d4tb01722f.
Habiburrohman, Musyafa Riziq, Muhammad Amir Jamilludin, Nilam Cahyati, Nendar Herdianto, and Yusril Yusuf. 2025. “Fabrication and Cytocompatibility Evaluation of Porous Bone Scaffold Based on Cuttlefish Bone-Derived Nano-Carbonated Hydroxyapatite Reinforced with Polyethylene Oxide/chitosan Fibrous Structure.” RSC Advances 15 (7): 5135–50.
HariniRamesh, Subhashree Rohinikumar, Thiyaneswaran Nesappan, and Sahanaselvaganesh. 2025. “PATIENT RELATED OUTCOME MEASURES OF SINGLE POSTERIOR DENTAL IMPLANT CROWNS FABRICATED THROUGH DIGITAL WORKFLOW.” Cuestiones de Fisioterapia 54 (2): 2186–98.
Ji, Eunhyun, Young Hoon Song, Jae Kyeong Lee, Yesol Kim, Eunji Lee, Kye Il Joo, and Jeong Hyun Seo. 2025. “Bioadhesive Levan-Based Coaxial Nanofibrous Membranes with Enhanced Cell Adhesion and Mesenchymal Stem Cell Differentiation.” Carbohydrate Polymers 354 (April):123337.
Lopes, Diana Lorena Garcia, Sérgio Lúcio Pereira de Castro Lopes, Daniela Maria de Toledo Ungaro, Ana Paula Martins Gomes, Nicole Berton de Moura, Bianca Costa Gonçalves, and Andre Luiz Ferreira Costa. 2025. “Radiomics-Driven CBCT Texture Analysis as a Novel Biosensor for Quantifying Periapical Bone Healing: A Comparative Study of Intracanal Medications.” Biosensors 15 (2). https://doi.org/10.3390/bios15020098.
Lou, Lan, and Hongyan Chen. 2023. “Functional Modification of Gelatin-Based Biodegradable Composite Films: A Review.” Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment, July. https://doi.org/10.1080/19440049.2023.2222844.
Mehta, Saumya, Subhashree Rohinikumar, Abhinav Rajendra Prabhu, Thiyaneswaran Nesappan, Vishnu Priya Veeraraghavan, and Rajalakshmanan Eswaramoorthy. 2023. “Gene Expression Analysis of Alkaline Phosphatase in Peri-Implantitis Tissue.” Bioinformation 19 (4): 506–9.
Ramezani, Mina, Nafiseh Baheiraei, S. Zahra Bathaie, Mehdi Razavi, and Nasim Naderi. 2025. “Alginate Hydrogel-Encapsulated Bone Marrow-Derived Mesenchymal Stem Cells and Crocin Improve Cardiac Function in a Rat Model of Myocardial Infarction.” International Journal of Biological Macromolecules, February, 141548.
Rupashri, S. V., Sahana Selvaganesh, Rajalakshmanan Eahwaramoorthy, and Thiyaneswaran Nesappan. 2024. “Herbal Formulation of High Phenols and Flavonoids with the Extract of Phyllanthus emblica, Punica granatum, and Illicium verum and Assessment of Hematotoxicity Assay: An In vitro Study.” Annals of African medicine 23 (3): 437–42.
Surendran, Sundaram, Subhashree Rohinikumar, Rajalakshmanan Eswaramoorthy, Karthik M, Thiyaneswaran Nesappan, and Abhinav Rp. 2023. “Chitosan-Reinforced Gelatin Microspheres-Modified Glass Ionomer Cement (GIC): A Novel Bone Alloplast Graft Material Synthesis and an In Vivo Analysis.” Cureus 15 (12): e50384.
Wang, Yilong, Xingyu Zhou, Junhui Jiang, Tianhao Zhao, Junbo Dang, Ruibo Hu, Chen Shen, Qiaochu Fan, Dahui Sun, and Mei Zhang. 2025. “Carboxymethyl Chitosan-Enhanced Multi-Level Microstructured Composite Hydrogel Scaffolds for Bone Defect Repair.” Carbohydrate Polymers 348 (Pt B): 122847.
Yuan, Zhengchao, Siyuan Wu, Liwen Fu, Xinyi Wang, Zewen Wang, Muhammad Shafiq, Hao Feng, et al. 2025. “A Natural Biological Adhesive from Slug Mucus for Wound Repair.” Bioactive Materials 47 (May):513–27.
Downloads
Published
How to Cite
Issue
Section
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
You are free to:
- Share — copy and redistribute the material in any medium or format
- Adapt — remix, transform, and build upon the material for any purpose, even commercially.
Terms:
- Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
