Change of Antioxidant System in Diabetic Model Rat Liver Cells and Its Correction with Complex Compounds
DOI:
https://doi.org/10.52783/jns.v14.2380Keywords:
Diabetes, Metformin, taurine, Schiff base, alloxan, antioxidant, lipid peroxidation, liver, alanine aminotransferase, aspartate aminotransferase, malondialdehydeAbstract
Diabetes is the most common disease associated with metabolic disorders. Diabetes mellitus is characterized by dysfunction of pancreatic beta cells. Taurine is a β-amino acid widely distributed in mammalian tissues and is not involved in protein synthesis. This study aimed to study the effect of a complex combination of taurine and a Schiff base derivative on the antioxidant system in the liver of model rats with diabetes. 12 male white rats were divided into 4 groups: Control, diabetic model (DM), diabetic treated with Metformin (DM+Metformin), and diabetic treated with Taurine and Schiff base (DM+Tau/Schiff base). Rats were injected subcutaneously for 3 days at a dose of 140 mg/kg of alloxan to induce diabetes. It was observed that blood glucose levels and daily water intake increased over two weeks, and body weight decreased. The 3rd and 4th groups with diabetes were treated with Metformin and a complex combination for 10 days. Treatment with taurine reduced the decrease in liver catalase and protein content and lowered the increased levels of gamma-glutamyl transferase (GGT), alanine aminotransferase (ALT), and aspartate aminotransferase (AST) in the blood. In addition, it was found to reduce the level of malondialdehyde (MDA), a secondary metabolite of lipids in the liver and blood. These results indicate that taurine and the Schiff base complex effectively alleviate diabetes by reducing oxidative stress and blood glucose levels.
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