Evaluation of Liver panel and Electrolytes in Individuals with Isolated Hyperbilirubinemia

Authors

  • Prerna Singh
  • Chanchal Garg
  • Divya Murugan

DOI:

https://doi.org/10.52783/jns.v14.2472

Keywords:

N/A

Abstract

Background: An elevation in serum bilirubin levels without significant changes in liver enzymes or other biochemical markers, presents a unique diagnostic challenge. In evaluating these patients, liver enzyme levels play a key role in differentiating between hepatic and non-hepatic causes of hyperbilirubinemia.

Methodology: A cross-sectional study was conducted on 200 patients with isolated hyperbilirubinemia at Raipur Institute of Medical Science & Hospital, Chhattisgarh, over two years. Patients aged 18 and above were included. Data were analysed using SPSS version 20, with descriptive statistics (mean & SD), and a p-value < 0.05 considered significant.

Result: The study included 200 subjects (63% female, 37% male) with elevated bilirubin levels, with a mean age of 34.23 ± 15.56 years. Total bilirubin was 15.34 ± 8.54 mg/dl. Significant differences were found between genders for direct bilirubin, ALT, creatinine, and urea.

Conclusion: Assessing bilirubin, liver enzymes, and electrolytes in isolated hyperbilirubinemia aids in differentiating benign conditions from more serious ones.

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

References

Wolkoff W. Bilirubin Metabolism and hyperbilirubinemias. In: Harrison’s Principles of Internal Medicine. Eugene B et al (Eds),16th ed. McGraw-Hill 2005; 1928-30.

Hayes PC. Liver and biliary tract disease. In Davidson’s principle and practice of medicine. Cristopher H et al (eds), 20th Ed, Churchill Livingstone 2007;944-6.

Olison R. Clinical experience with isolated hyperbilirubinemia. Scand J Gastroenterol 1989:24;617-22.

Farheen S, Sengupta S, Santra A, et al. Gilbert’s syndrome: high frequency of the (TA)7TAA allele in India and its interaction with a novel CAT insertion in promoter of the gene for bilirubin UDP-glucuronosyltransferase 1 gene. World J Gastroenterol 2006;12(14):2269–2275. DOI: 10.3748/wjg.v12.i14.2269.

Fevery J. Bilirubin in clinical practice: a review. Liver Int 2008;28(5): 592–605. DOI: 10.1111/j.1478-3231.2008.01716.x.

Bosma PJ, Chowdhury JR, Bakker C, et al. The genetic basis of the reduced expression of bilirubin UDP-glucuronosyltransferase 1 in Gilbert’s syndrome. N Engl J Med 1995;333(18):1171–1175. DOI: 10.1056/NEJM199511023331802.

Lee JH, Moon KR. Coexistence of Gilbert syndrome and hereditary spherocytosis in a child presenting with extreme jaundice. Pediatr Gastroenterol Hepatol Nutr 2014;17(4):266–269. DOI: 10.5223/ pghn.2014.17.4.266.

Kumari S, Bhatnagar S, Khanna C, Sethi T, Mullick DN. Neonatal jaundice: association with neonatal septicemia. Indian Pediatr. 1987;24(5):433–5.

Farheen S, Sengupta S, Santra A, et al. Gilbert’s syndrome: high frequency of the (TA)7TAA allele in India and its interaction with a novel CAT insertion in promoter of the gene for bilirubin UDP-glucuronosyltransferase 1 gene. World J Gastroenterol 2006;12(14):2269–2275. DOI: 10.3748/wjg.v12.i14.2269.

Wazib A, Hossain MZ, Saha JK, et al. A case of Gilbert’s syndrome. J Dhaka Med Coll 2010;19(1):67–68. DOI: 10.3329/jdmc.v19i1.6257.

Khan S. Elevated serum bilirubin in acute appendicitis: a new diagnostic tool. Kathmandu Univ Med J. 2008;6:161–5.

Murtaza, Joshi VV. Unconjugated hyperbilirubinemia in commercial pilot: A clinical dilemma. Ind J Aerospace Med 53(2), 2009.

Kotal P, Vitek L, Fevery J. Fasting-related hyperbilirubinemia in rats: the effect of decreased intestinal motility. Gastroenterology 1996;111(1):217–223. DOI: 10.1053/gast.1996.v111.pm8698202.

Mendez-Sanchez N, Almeda-Valdes P, Uribe M, et al. The management of incidental fatty liver found on imaging. What do we need to do? Am J Gastroenterol 2018;113:1274–6.

Manual of Civil Aviation Medicine, International Civil Aviation Organization. In: Haematology:III5- Available from:http://www.icao.int.icaonet/dcs/8984. Accessed Oct 15, 2009.

Jiraskova A, Novotny J, Novotny L, et al. Association of serum bilirubin and promoter variations in HMOX1 and UGT1A1 genes with sporadic colorectal cancer. Int J Cancer 2012;131(7):1549–1555. DOI: 10.1002/ ijc.27412.

Downloads

Published

2025-03-22

How to Cite

1.
Singh P, Garg C, Murugan D. Evaluation of Liver panel and Electrolytes in Individuals with Isolated Hyperbilirubinemia. J Neonatal Surg [Internet]. 2025Mar.22 [cited 2025Sep.26];14(4):55-9. Available from: https://www.jneonatalsurg.com/index.php/jns/article/view/2472