The Relationship Between Administered Midazolam Dosage as Premedication and Cortisol Levels in Gastrointestinal Endoscopy Patients
DOI:
https://doi.org/10.52783/jns.v14.2687Keywords:
Endoscopy, Midazolam, Propofol, Cortisol, TIVAAbstract
Gastrointestinal endoscopy is crucial for diagnosis and treatment, but patients often experience anxiety as a result. This anxiety affects the outcome of the procedure and recovery. Midazolam, an effective premedication, reduces anxiety without disrupting vital functions. This study investigated how Midazolam correlates with physiological indicators and stress responses during endoscopy, focusing on cortisol levels and the Bispectral Index Score (BIS). This study was aimed to evaluate the relationship between Midazolam administration and cortisol levels as well as the Bispectral Index Score (BIS) in patients undergoing endoscopy with Total Intravenous Anesthesia (TIVA). This study employed a comparative experimental design to compare BIS and cortisol levels in patients received three different doses of Midazolam for gastrointestinal endoscopy. Participants were randomly selected from patients at RSUA Surabaya. Data analysis was performed using parametric and non- parametric statistical tests based on distribution. This quasi-experimental study compared the effects of Midazolam dose as premedication on cortisol levels and sedation depth monitoring via BIS. Thirty gastrointestinal endoscopy subjects at RSUA were randomly selected. Results showed a significant decrease in blood pressure and BIS in the Midazolam group with 0.06 mg/kg, but still within safe limits. The Kruskal-Wallis test indicated no significant difference in pre- and post-procedure cortisol levels (p=0.382). This study confirmed Midazolam's effectiveness in maintaining sedation without affecting hemodynamics or respiratory functions. There is no significant relationship between the administration of midazolam as premedication and cortisol levels in patient undergoing gastrointestinal endoscopy.
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