Headache and Migraine in Patients with Asthma
DOI:
https://doi.org/10.52783/jns.v14.2689Keywords:
Asthma, migraine, headacheAbstract
Objectives: Severe headaches are the hallmark of the migraine condition, which also has systemic and neurological symptoms. This study aims to determine the prevalence of migraine and explore potential associations between migraine, atopic diseases, and parental history in asthmatic patients.
Material And Methods: A total of 72 outpatients with asthma who were diagnosed, according to the hospital database, by an early or late test of reversibility demonstrating a reversible airway obstruction, were included. Questions about the history of asthma, atopic disorders, migraine, and headaches as well as atopic symptoms were asked. The neurology department examined the headacheing individuals and looked into the possibility of migraine. If a patient met the criteria established by the International Headache Society (IHS), a diagnosis of migraine headache was made.
Results: In 60.4% of cases, a headache was mentioned. Three quarters of the patients, had headaches that satisfied the IHS criteria for migraine. Aura-associated migraine affected just 3 people. There were atopic symptoms in 86.8% of individuals. Based on the medical history of the parents, 47.9% had asthma, 39.6% had atopic symptoms, and 22.2% had migraines. It was discovered that patients with atopic symptoms had a noticeably higher frequency of headaches (65.3%) "p=0.007". Patients who had parents who had atopic symptoms had a significantly higher prevalence of migraines (54%) "p=0.002". Gender, smoking, allergens and migraine, and parental history of asthma were found to be independent risk factors for the presence of migraine in asthmatics using multiple logistic regression analysis.
Conclusion: Patients with asthma have a high frequency of migraine headaches. The coexistence of headaches and asthma may be linked to a similar pathophysiological mechanism; smoking, shared genetic components, and family history may all be important components of this mechanism. Clinicians should inquire about atopic symptoms, family history, and headaches in patients with asthma. They should also exercise caution when suspecting migraines.
Downloads
Metrics
References
Headache Classification Subcommittee of the International Headache Society. Classification of Headache Disorders, 2nd Edition. Cephalalgia. 2004;24(Suppl 1):1–151. doi: 10.1111/j.1468-2982.2003.00824.x. [DOI] [PubMed] [Google Scholar]
Edvinsson L, Uddman R. Neurobiology in primary headaches. Brain Res Brain Res Rev. 2005;48:438–56. doi: 10.1016/j.brainresrev.2004.09.007. https://doi.org/10.1016/j.brainresrev.2004.09.007. [DOI] [PubMed] [Google Scholar]
Katsarava Z, Buse DC, Manack AN, et al. Defining the differences between episodic migraine and chronic migraine. Curr Pain Headache Rep. 2012;16:86–92. doi: 10.1007/s11916-011-0233-z. https://doi.org/10.1007/s11916-011-0233-z. [DOI] [PMC free article] [PubMed] [Google Scholar]
Davey G, Sedgwick P, Maier W, et al. Association between migraine and asthma: matched case-control study. Br J Gen Pract. 2002;52:723–7. [PMC free article] [PubMed] [Google Scholar]
Yilmaz IA, Ozge A, Erdal ME, et al. Cytokine polymorphism in patients with migraine: some suggestive clues of migraine and inflammation. Pain Med. 2010;11:492–7. doi: 10.1111/j.1526-4637.2009.00791.x. https://doi.org/10.1111/j.1526-4637.2009.00791.x. [DOI] [PubMed] [Google Scholar]
Ozge A, Ozge C, Oztürk C, et al. The relationship between migraine and atopic disorders-the contribution of pulmonary function tests and immunological screening. Cephalalgia. 2006;26:172–9. doi: 10.1111/j.1468-2982.2005.01021.x. https://doi.org/10.1111/j.1468-2982.2005.01021.x. [DOI] [PubMed] [Google Scholar]
Aamodt AH, Stovner LJ, Langhammer A, et al. Is headache related to asthma, hay fever, and chronic bronchitis? The HeadHUNT Study. Headache. 2007;47:204–12. doi: 10.1111/j.1526-4610.2006.00597.x. https://doi.org/10.1111/j.1526-4610.2006.00597.x. [DOI] [PubMed] [Google Scholar]
Martin VT, Fanning KM, Serrano D, et al. Asthma is a risk factor for new onset chronic migraine: Results from the American migraine prevalence and prevention study. Headache. 2016;56:118–31. doi: 10.1111/head.12731. https://doi.org/10.1111/head.12731. [DOI] [PubMed] [Google Scholar]
Ertas M, Baykan B, Kocasoy Orhan E, et al. One-year prevalence and the impact of migraine and tensiontype headache in Turkey: a nationwide home-based study in adults. J Headache Pain. 2012;13:147–57. doi: 10.1007/s10194-011-0414-5. https://doi.org/10.1007/s10194-011-0414-5. [DOI] [PMC free article] [PubMed] [Google Scholar]
Breslau N, Rasmussen BK. The impact of migraine. Epidemiology, risk factors, and co-morbidities. Neurology. 2001;56:4–12. doi: 10.1212/wnl.56.suppl_1.s4. https://doi.org/10.1212/WNL.56.suppl_1.S4. [DOI] [PubMed] [Google Scholar]
Ku M, Silverman B, Prifti N, et al. Prevalence of migraine headaches in patients with allergic rhinitis. Ann Allergy Asthma Immunol. 2006;97:226–30. doi: 10.1016/S1081-1206(10)60018-X. https://doi.org/10.1016/S1081-1206(10)60018-X. [DOI] [PubMed] [Google Scholar]
Chen TC, Leviton A. Asthma and eczema in children born to women with migraine. Arch Neurol. 1990;47:1227–30. doi: 10.1001/archneur.1990.00530110087022. https://www.ncbi.nlm.nih.gov/pubmed/?term=Chen%20TC%5BAuthor%5D&cauthor=true&cauthor_uid=2241619. [DOI] [PubMed] [Google Scholar]
Alehan F, Ozçay F, Erol I, et al. Increased risk for coeliac disease in paediatric patients with migraine. Cephalalgia. 2008;28:945–9. doi: 10.1111/j.1468-2982.2008.01630.x. https://doi.org/10.1111/j.1468-2982.2008.01630.x. [DOI] [PubMed] [Google Scholar]
Heatley RV, Denburg JA, Bayer N, et al. Increased plasma histamine levels in migraine patients. Clin Allergy. 1982;12:145–9. doi: 10.1111/j.1365-2222.1982.tb01633.x. https://doi.org/10.1111/j.1365-2222.1982.tb01633.x. [DOI] [PubMed] [Google Scholar]
Gazerani P, Pourpak Z, Ahmadiani A, et al. Correlation between migraine, histamine and immunoglobulin E. Scand J Immunol. 2003;57:286–90. doi: 10.1046/j.1365-3083.2003.01216.x. https://doi.org/10.1046/j.1365-3083.2003.01216.x. [DOI] [PubMed] [Google Scholar]
Skoner DP. Allergic rhinitis: definition, epidemiology, pathophysiology, detection, and diagnosis. J Allergy Clin Immunol. 2001;108:2–8. doi: 10.1067/mai.2001.115569. https://doi.org/10.1067/mai.2001.115569. [DOI] [PubMed] [Google Scholar]
Rozen TD. A history of cigarette smoking is associated with the development of cranial autonomic symptoms with migraine headaches. Headache. 2011;51:85–91. doi: 10.1111/j.1526-4610.2010.01707.x. https://doi.org/10.1111/j.1526-4610.2010.01707.x. [DOI] [PubMed] [Google Scholar]
Chen TC, Leviton A, Edelstein S, et al. Migraine and other diseases in women of reproductive age. The influence of smoking on observed association. Arch Neurol. 1987;44:1024–8. doi: 10.1001/archneur.1987.00520220030011. https://doi.org/10.1001/archneur.1987.00520220030011. [DOI] [PubMed] [Google Scholar]
Lassen LH, Ashina M, Christiansen I, et al. Nitric oxide synthase inhibition in migraine. Lancet. 1997;349:401–2. doi: 10.1016/s0140-6736(97)80021-9. https://doi.org/10.1016/S0140-6736(97)80021-9. [DOI] [PubMed] [Google Scholar
Downloads
Published
How to Cite
Issue
Section
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
You are free to:
- Share — copy and redistribute the material in any medium or format
- Adapt — remix, transform, and build upon the material for any purpose, even commercially.
Terms:
- Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
