Clinical Presentation And Management Of Central Neurocytoma In Pediatric Age Group
DOI:
https://doi.org/10.52783/jns.v14.2977Keywords:
Central Neurocytoma, Pediatric Brain Tumor, Intraventricular Tumor, Neuro-oncology, Rare Pediatric TumorAbstract
Central neurocytoma is a rare, typically benign intraventricular tumor primarily affecting young adults, but its occurrence in the pediatric population is exceptionally uncommon. This case report aims to highlight the clinical presentation, radiologic features, surgical management, and the outcome of a pediatric central neurocytoma. Herewith, we report the case of a toddler who presented with signs of raised intracranial pressure. Magnetic resource imaging (MRI) brain revealed heterogenous soft tissue showing enhancement in right lateral ventricle lesion extending into third ventricle and aqueduct of Sylvius leading to resultant obstructive hydrocephalus. Patient underwent endoscopic septostomy with maximal safe resection and was diagnosed with Central Neurocytoma (WHO Grade 2) based on immunohistochemistry (IHC) analysis of intraoperative tissue sample. Despite the rarity of central neurocytomas in children, early diagnosis and appropriate management can lead to excellent long-term prognosis, emphasizing the importance of awareness among clinicians of this entity.
Downloads
Metrics
References
David N. Louis, Hiroko Ohgaki, Otmar D. Wiestler et al. WHO Classification of Tumours of the Central Nervous System. (2016) ISBN: 9789283244929 - Google Books
Louis, D. N., et al. (2007). "The 2007 WHO classification of tumours of the central nervous system." Acta Neuropathologica, 114(2), 97–109
Hallock A, Hamilton B, Ang LC, Tay KY, Meygesi JF, Fisher BJ, et al. Neurocytomas: long-term experience of a single institution. J Neurooncol 2011;13(9):943–9.
Rades D, Schild SE, Fehlauer F. Defining the best available treatment for neurocytomas in children. Cancer. 2004;101:2629–32. doi: 10.1002/cncr.20695. [DOI] [PubMed] [Google Scholar]
Baishya BK, Singh RK, Dutta D, Hussain Z. Pediatric central neurocytoma: Case report and review of literature. J Pediatr Neurosci. 2016 Oct-Dec;11(4):348-350. doi: 10.4103/1817-1745.199485. PMID: 28217163; PMCID: PMC5314854
Sun S, Malicki DM, Levy ML, et alAtypical central neurocytoma with aggressive features in a childBMJ Case Reports CP 2020;13:e236262
Front. Neurol., 22 December 2021 Sec. Neuro-Oncology and Neurosurgical Oncology.Volume 12 - 2021 | https://doi.org/10.3389/fneur.2021.790641
Patel DM, Schmidt RF, Liu JK. Update on the diagnosis, pathogenesis, and treatment strategies for central neurocytoma. J Clin Neurosci 2013;20 (9):1193–9.
Rai P, Nayak R, Anand D, Menon G: Central neurocytoma in the posterior fossa. BMJ Case Rep. 2019, 12:10.1136/bcr-2019-231626
Y. Song, X. Kang, G. Cao et al., “Clinical characteristics and prognostic factors of brain central neurocytoma,” Oncotarget, vol. 7, no. 46, pp. 76291–76297, 2016.
D. M. Patel, R. F. Schmidt, and J. K. Liu, “Update on the diag nosis, pathogenesis, and treatment strategies for central neuro cytoma,” Journal of Clinical Neuroscience, vol. 20, no. 9, pp. 1193–1199, 2013
A. M.Richardson, V. L. Armstrong, J. E. Gernsback, S. H. Gul tekin, and R. J. Komotar, “Central neurocytoma: rare presenta tion in fourth ventricle and review of literature,” World Neurosurgery, vol. 123, pp. 357–361, 2019.
S. J. Lee, T. T. Bui, C. H. Chen et al., “Central neurocytoma: a review of clinical management and histopathologic features,” Brain Tumor Research and Treatment, vol. 4, no. 2, pp. 49 57, 2016.
Li X, Guo L, Sheng S, et al. Diagnostic value of six MRI features for central neurocytoma. Eur Radiol 2018; 28(10): 4306–4313.
Collins VP, Jones DT and Giannini C. Pilocytic astrocy toma: pathology, molecular mechanisms and markers. Acta Neuropathol 2015; 129(6): 775–788.
M. Wang, P. Zhou, S. Zhang et al., “Clinical features, treat ment, and long-term outcomes of central neurocytoma: a 20 year experience at a single center,” World Neurosurgery, vol. 109, pp. e59–e66, 2018.
M. H. Schmidt, O. N. Gottfried, C. S. von Koch, S. M. Chang, and M. W. McDermott, “Central neurocytoma: a review,” Journal of Neuro-Oncology, vol. 66, no. 3, pp. 377–384, 2004.
A. K. Mahavadi, P. M. Patel, M. Kuchakulla et al., “Central neurocytoma treatment modalities: a systematic review asses sing the outcomes of combined maximal safe resection and radiotherapy with gross total resection,” World Neurosurgery, vol. 137, pp. e176–e182, 2020.
Downloads
Published
How to Cite
Issue
Section
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
You are free to:
- Share — copy and redistribute the material in any medium or format
- Adapt — remix, transform, and build upon the material for any purpose, even commercially.
Terms:
- Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
