Assessment Of Some Inflammatory Mediator’s Role in Obese Males
DOI:
https://doi.org/10.52783/jns.v14.3188Keywords:
Obesity, BMI, TGF-β, MH, DII, DILAbstract
iObesity iis ia isubstantial iissue ithat ireduces ithe iquality iof ilife ifor inumerous iindividuals iand iincreases itheir isusceptibility ito ivarious idiseases. iInflammation iplays ia icrucial irole iin ithe idevelopment iof iobesity iand iacts ias ia icentral ifactor ifor ithe iinteractions iof icellular iand ihumoral icomponents iinside iadipose itissue. iThe iresearch isought ito iinvestigate iobesity-associated iinflammatory imarkers, ispecifically iIL-1α, iIL-1β, iTGF-Beta1, iand iTGF-Beta2, iin iindividuals iwith iobesity iand ihealthy icontrols. iThe istudy ifeatured ia itotal iof i160 ipatients, icomprising i120 iobese icases iand i40 icontrols, iconducted ifrom iJanuary i2024 ito iJune i2024. iThe isamples iunderwent icentrifugation (3000 g, i20 min), iSubsequently, ithe iserum iwas iseparated iand ipreserved iat i-20°C. iSerum ifrom iboth ithe ipatient iand icontrol iwas isubjected ito ienzyme-linked iimmunosorbent iassays i(ELISA) ifor (IL-1α, iIL-1β, iTGF-β1, iand iTGF-β2). iThe icurrent istudy iincluded i160 iparticipants iat ivarious istages iof iobesity, iindicating ithat ithe imajority iof ioverweight iindividuals iwere iaged i20-30, icomprising i30 isubjects (83.33%). iThe irecent ifindings iindicated ithat ithe imean iTGF-β2 iwas iconsiderably ihighest iin iobese itype iII ipatients (274.8 ing/L). iTGF-β1 iwas iconsiderably ihigheri(P<0.05) iin iobese itype iII iparticipants, iwith ia imean iof i51.67 ing/L. iSimilarly, ithe ilevels iof iIL-1α iand iIL-1β idid inot idemonstrate isignificant idifferences iacross ithe iresearch igroups, iwith iP>0.05. iThe icurrent istudy irevealed ithat iTGF-β1 iand iTGF-β2 imay ihave ia isignificant irole iin ilipid imetabolism, iparticularly iin iindividuals iwith iinsulin iresistance. i
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