Design, Characterization And Molecular Docking Of Isatin Derivative
DOI:
https://doi.org/10.52783/jns.v14.3256Keywords:
Aniline , derivatives , IsatinAbstract
Isatin (2,3-dioxindole) is an important class of heterocyclic compounds, isatin derivatives are synthetically important substrates, which can be used for many synthesis of a large variety of heterocyclic compounds, and as raw material for drug synthesis. Recently, isatin derivatives have attracted strong interest in organic and medicinal chemistry due to their potent biological and pharmacological activities
Downloads
Metrics
References
AJMER SINGH GREWAL∗ JCDM College of Pharmacy, Sirsa-125055, Haryana (India)
Da Silva JFM, Garden SJ, Pinto AC, The chemistry of isatins: a review from 1975 to 1999, Journal of Brazilian Chemical Society, 2001; 12(3): 273-324.
Bhrigu B, Pathak D, Siddiqui N, Alam MS, Ahsan W, Search for biological active isatins: a short review, International Journal of Pharmaceutical Sciences and Drug Research, 2010; 2(4): 229-235.
Chen et al. Chemistry Central Journal 2011
Vendemiale G, Grattagliano I, Altomare E: An update on the role of free radicals and antioxidant defense in human disease. Int J Clin Lab Res 1999, 29:49-55.
Valko M, Rhodes CJ, Moncol J, Izakovic M, Mazur M: Free radicals, metals and antioxidants in oxidative stress-induced cancer. Chem Biol Interact 2006, 160:1-40.
Cooke MS, Evans MD, Dizdaroglu M, Lunec J: Oxidative DNA damage: mechanisms, mutation and disease. FASEB J 2003, 17:1195-1214.
Journal of Advanced Pharmaceutical Technology & Research | Jul-Sep 2010 | Vol 1 | Issue 3
Article in International Journal of Research in Pharmaceutical Sciences · April 2010
Aboul-Fadl T, Mohammed FA, Hassan EA. Synthesis, Antitubercular Activity and Pharmacokinetic Studies of Some Schiff Bases Derived from 1- Alkylisatin and Isonicotinic Acid Hydrazide (INH). Arch. Pharm. Res. 2003, 26: 778–784.
Bal TR, Anand B, Yogeeswari P, Sriram D. Synthesis and evaluation of anti-HIV activity of isatin β-thiosemicarbazone derivatives. Bioorg. Med. Chem. Lett. 2005, 15: 4451– 4455.
Ballell L, Field RA, Duncan K, Young RJ. New small-molecule synthetic antimycobacterials. Antimicrob. Agents Chemother. 2005, 49: 2153–2163.
Medvedev A, Buneeva O, Gnedenko O, Ershov P, Ivanov A, et al. (2018) Isatin, an endogenous nonpeptide biofactor: A review of its molecular targets, mechanisms of actions, and their biomedical implications. Biofactors 44(2): 95-108
Downloads
Published
How to Cite
Issue
Section
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
You are free to:
- Share — copy and redistribute the material in any medium or format
- Adapt — remix, transform, and build upon the material for any purpose, even commercially.
Terms:
- Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
