Ashwagandha as an Adaptogen: Evidence-Based Role in Alleviating Stress and Anxiety
DOI:
https://doi.org/10.52783/jns.v14.3326Abstract
Withania somnifera, commonly known as Ashwagandha, is an important medicinal plant widely recognized for its adaptogenic and anxiolytic effects. In recent years, growing interest has emerged in its role as a natural remedy for stress and anxiety disorders. This review explores the scientific evidence supporting the use of Ashwagandha in managing psychological stress and anxiety. Various clinical trials and experimental studies suggest that Ashwagandha can effectively reduce cortisol levels, improve mood, and enhance overall stress resilience. The mechanisms behind these effects include modulation of the hypothalamic-pituitary-adrenal (HPA) axis, antioxidant activity, and interaction with neurotransmitters. Given its safety profile and therapeutic potential, Ashwagandha may serve as a valuable complementary treatment in stress and anxiety management.
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Auddy, B., Hazra, J., Mitra, A., Abedon, B., & Ghosal, S. (2008). A standardized Withania somnifera extract significantly reduces stress-related parameters in chronically stressed humans: A double-blind, randomized, placebo-controlled study. Journal of the American Nutraceutical Association, 11(1), 50–56.
Baldwin, D. S., Anderson, I. M., Nutt, D. J., Bandelow, B., Bond, A., Davidson, J. R., … & Wittchen, H. U. (2014). Evidence-based pharmacological treatment of anxiety disorders, post-traumatic stress disorder and obsessive-compulsive disorder: A revision of the 2005 guidelines from the British Association for Psychopharmacology. Journal of Psychopharmacology, 28(5), 403–439. https://doi.org/10.1177/0269881114525674
Bhattacharya, S. K., Bhattacharya, A., Sairam, K., & Ghosal, S. (2000). Anxiolytic-antidepressant activity of Withania somnifera glycowithanolides: An experimental study. Phytomedicine, 7(6), 463–469. https://doi.org/10.1016/S0944-7113(00)80030-6
Chandrasekhar, K., Kapoor, J., & Anishetty, S. (2012). A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of Ashwagandha root in reducing stress and anxiety in adults. Indian Journal of Psychological Medicine, 34(3), 255–262. https://doi.org/10.4103/0253-7176.106022
Cooley, K., Szczurko, O., Perri, D., Mills, E. J., Bernhardt, B., & Seely, D. (2009). Naturopathic care for anxiety: A randomized controlled trial. PLoS ONE, 4(8), e6628. https://doi.org/10.1371/journal.pone.0006628
Gupta, A., Kaur, G., & Bansal, P. (2021). Therapeutic potential of Withania somnifera: A mini-review. Journal of Ethnopharmacology, 275, 114098. https://doi.org/10.1016/j.jep.2021.114098
Kuboyama, T., Tohda, C., & Komatsu, K. (2005). Neuritic regeneration and synaptic reconstruction induced by Withania somnifera in damaged neurons. NeuroReport, 16(6), 541–544. https://doi.org/10.1097/00001756-200504250-00005
Lopresti, A. L., Smith, S. J., Malvi, H., & Kodgule, R. (2019). A randomized, double-blind, placebo-controlled, crossover study examining the hormonal and vitality effects of Ashwagandha (Withania somnifera) in aging, overweight males. American Journal of Men’s Health, 13(1), 1–10. https://doi.org/10.1177/1557988319835985
Panossian, A., & Wikman, G. (2008). Effects of adaptogens on the central nervous system and the molecular mechanisms associated with their stress-protective activity. Pharmaceuticals, 1(1), 85–102. https://doi.org/10.3390/ph1010085
Singh, N., Bhalla, M., de Jager, P., & Gilca, M. (2011). An overview on Ashwagandha: A Rasayana (rejuvenator) of Ayurveda. African Journal of Traditional, Complementary and Alternative Medicines, 8(5 Suppl), 208–213. https://doi.org/10.4314/ajtcam.v8i5S.9
Tandon, N., & Yadav, S. S. (2020). Safety and clinical effectiveness of Withania somnifera (L.) Dunal root in human ailments: A systematic review. Journal of Ethnopharmacology, 255, 112768. https://doi.org/10.1016/j.jep.2020.112768
World Health Organization (WHO). (2021). Mental health and COVID-19: Early evidence of the pandemic’s impact. Geneva: World Health Organization. https://www.who.int/publications/i/item/9789240024265
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