Formulations, Characterization and Evaluation of Clarithromycin loaded Mucoadhesive Microspheres for Peptic Ulcers
DOI:
https://doi.org/10.52783/jns.v14.3373Keywords:
Mucoadhesive, Microspheres, Polymers, UlcersAbstract
Mucoadhesive formulations orally would achieve a substantial increase in the length of stay of the drug in GI tract. Mucoadhesive microsphere carrier systems are made from the biodegradable polymers in sustained drug delivery. Among all the fabricated formulations, F9 was optimized as final formulation showing first order release kinetics and extended drug release profile over a period of 10h (73.1%) and fitted to our desired target, with acceptable microencapsulation efficiency (78 %) and mucoadhesive property (76%). having good flow properties, and smaller particle size (204±09). the formulation F9 also showed good swelling index (76%). The SEM results indicated that the formulation F9 was spherical and having porous surface,which can influence the rate of release of drug from the microspheres.
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