Unmasking The Impostor: Myxoid Liposarcoma Of The Arm Masquerading As A Spindle Cell Lesion – A Rare Case Report
DOI:
https://doi.org/10.63682/jns.v14i8S.3422Keywords:
Myxoid liposarcoma, liposarcoma, lipoblasts, spindle cell neoplasmAbstract
BACKGROUND: Myxoid liposarcoma (MLPS) is a malignant tumour composed of uniform, round to ovoid cells with variable numbers of small lipoblasts, set in a myxoid stroma with arborizing vasculature. MLPS typically present within deep soft tissues of the extremities, often thigh and rarely from the upper extremities, subcutis or retroperitoneum. MLPS accounts 20-30% of liposarcoma and 5% of adult soft tissue sarcomas with a peak incidence in the fourth to fifth decades.
CASE REPORT: We present a case of 23 years old female with sudden onset painful right arm swelling. MRI right arm was suggestive of vascular lesion while MRI with contrast suggested it was a neurogenic tumor. Cytology findings suggested a mesenchymal lesion, with uncertain malignant potential. The histopathological and immunohistochemical findings were suggestive of Adipocytic tumor - Likely Myxoid Liposarcoma (FNCLCC Grade 2).
CONCLUSION: The case highlights the importance of including myxoid liposarcoma (MLPS) in the differential diagnosis of spindle cell lesions, especially when imaging and cytological findings are ambiguous. A multidisciplinary approach is essential for accurate diagnosis. Early detection of MLPS enables prompt treatment, ultimately improving patient prognosis and outcomes.
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WHO Classification Of Tumours Editorial Board. Soft tissue and bone tumours. Vol 3. 5th ed. Lyon (France) International Agency For Research On Cancer; 2020.
Choi JH, Ro JY. The recent advances in molecular diagnosis of soft tissue tumors. Int J Mol Sci. 2023;24(6).
Matsunobu T, Maekawa A, Inaba Y, Makihara K, Hisaoka M, Iwamoto Y. Myxoid liposarcoma in an 11-year-old patient. International Cancer Conference Journal. 2023 May 9;12(4):233–40.
Powers MP, Wang WL, Hernandez VS, et al. Detection of myxoid liposarcoma- associated FUS-DDIT3 rearrangement variants including a newly identified breakpoint using an optimized RT-PCR assay. Mod Pathol. 2010 Oct;23(10):1307-15.
Baumhoer D, Hench J, Amary F. Recent advances in molecular profiling of bone and soft tissue tumors. Skeletal Radiol [Internet]. 2024;53(9):1925–36. Singer S, Antonescu CR. Soft Tissue Tumors: Clinical Features and Management. J Clin Oncol. 2019;37(3):220-231.
Dashti NK, Schukow CP, Kilpatrick SE. Back to the future! Selected bone and soft tissue neoplasms with shared genetic alterations but differing morphological and immunohistochemical phenotypes. Human Pathology. 2024 May;147:129–38.
Goldblum JR, Folpe AL, Weiss SW. Enzinger and Weiss’s soft tissue tumors. 7th ed.Philadelphia, PA: Elsevier; 2020.
ABBREVATIONS:
MLPS: Myxoid liposarcoma
MRI: Magnetic Resonance Imaging
MGG: May-Grünwald-Giemsa
ALT/WDL: Atypical lipomatous tumour/well-differentiated liposarcoma
MRCLPS: Myxoid/round cell liposarcoma
FNCLCC: Fédération Nationale des Centres de Lutte Contre le Cancer
WHO: World Health organization.
FUS: Fused in Sarcoma
DDIT3: DNA damage-inducible transcript 3
EWSR1: Ewing sarcoma breakpoint region 1 or EWS RNA-binding protein 1
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