Correlation Of Serum Calcium Level with Gold Criteria in Chronic Obstructive Pulmonary Disease Patients in A Tertiary Care Centre Tamaka Kolar
DOI:
https://doi.org/10.52783/jns.v14.3615Keywords:
acute exacerbation, chronic obstructive pulmonary disease (COPD), GOLD (Global Initiative for Chronic Obstructive Lung Disease) criteria, Serum calcium levelAbstract
Introduction
Patients with acute exacerbation of chronic obstructive pulmonary disease (COPD) are at increased risk for morbidity and mortality compare to non-exacerbators. Electrolyte imbalances with calcium is most often reported in these patients. Correlation between serum calcium levels and GOLD (Global Initiative for Chronic Obstructive Lung Disease) criteria remains unclear.
Aims and objectives
This study aims to correlate serum calcium levels in acute exacerbation of COPD patients with GOLD criteria.
Materials and Methods
Forty-eight (48) patients with acute exacerbation of COPD were included in the study. Serum calcium levels were defined as per recent guidelines.Statistical analysis was performed using SPSS version 22.
Results
A total of 48 patients were included in which majority of people were between the ages 61and 70. The mean serum calcium levels were lower in patients with acute exacerbation of chronic obstructive pulmonary disease in which very low serum calcium level correlated with severe grade of GOLD criteria(viceversa) with significant p value of <0.05.
Conclusion
Our study indicated that hypocalcemia was associated with an elevated risk of COPD exacerbation.Hypocalcemia was correlated with GOLD criteria, the low the serum calcium level the severe the GOLD criteria.
Downloads
Metrics
References
Celli B, Fabbri L, Criner G, Martinez FJ, Mannino D, Vogelmeier C, et al. Definition and Nomenclature of Chronic Obstructive Pulmonary Disease: Time for Its Revision. Am J Respir Crit Care Med. 2022 Dec 1;206(11):1317–25.
Li H, Gao T, Fang W, Xian‐Yu C, Deng N, Zhang C, et al. Global, regional and national burden of chronic obstructive pulmonary disease over a 30‐year period: Estimates from the 1990 to 2019 Global Burden of Disease Study. Respirology. 2023 Jan 23;28(1):29–36.
SEEMUNGAL TAR, DONALDSON GC, PAUL EA, BESTALL JC, JEFFRIES DJ, WEDZICHA JA. Effect of Exacerbation on Quality of Life in Patients with Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med. 1998 May 1;157(5):1418–22.
Baird GS. Ionized calcium. Clinica Chimica Acta. 2011 Apr;412(9–10):696–701.
Vannucci L, Fossi C, Quattrini S, Guasti L, Pampaloni B, Gronchi G, et al. Calcium Intake in Bone Health: A Focus on Calcium-Rich Mineral Waters. Nutrients. 2018 Dec 5;10(12):1930.
CHENG H ping, WEI S, WEI L ping, VERKHRATSKY A. Calcium signaling in physiology and pathophysiology. Acta Pharmacol Sin. 2006 Jul;27(7):767–72.
Berchtold MW, Brinkmeier H, Müntener M. Calcium Ion in Skeletal Muscle: Its Crucial Role for Muscle Function, Plasticity, and Disease. Physiol Rev. 2000 Jul 1;80(3):1215–65.
Nanou E, Catterall WA. Calcium Channels, Synaptic Plasticity, and Neuropsychiatric Disease. Neuron. 2018 May;98(3):466–81.
Clapham DE. Calcium Signaling. Cell. 2007 Dec;131(6):1047–58.
Peacock M. Calcium Metabolism in Health and Disease. Clinical Journal of the American Society of Nephrology. 2010 Jan;5(Supplement_1):S23–30.
Tamondong-Lachica DR, Skolnik N, Hurst JR, Marchetti N, Rabe APJ, Montes de Oca M, et al. GOLD 2023 Update: Implications for Clinical Practice. Int J Chron Obstruct Pulmon Dis. 2023 May;Volume 18:745–54.
Downloads
Published
How to Cite
Issue
Section
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
You are free to:
- Share — copy and redistribute the material in any medium or format
- Adapt — remix, transform, and build upon the material for any purpose, even commercially.
Terms:
- Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
