Effect of Low-Level Laser Therapy on Osseointegration: A Comprehensive Review
DOI:
https://doi.org/10.63682/jns.v14i18S.5262Keywords:
Laser Therapy, Bone Regeneration, Dental Implants, PhotobiomodulationAbstract
Low-Level Laser Therapy (LLLT), also known as photobiomodulation, has garnered attention in the field of implant dentistry for its potential to enhance osseointegration—the direct structural and functional connection between living bone and the surface of a load-bearing implant. This review aims to critically evaluate the current evidence on the efficacy of LLLT in promoting bone regeneration and improving the integration of dental implants with surrounding bone tissue. By analysing both preclinical and clinical studies, we seek to elucidate the underlying mechanisms of LLLT and its practical applications in enhancing implant success rates.
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Berni, M. Brancato, A.M. Torriani, C. Bina, V. Annunziata, S. Cornella, E. et al. The Role of Low-Level Laser Therapy in Bone Healing: Systematic Review. Int. J. Mol. Sci. 2023;24:7094.
Bai, J., Li, L., Kou, N. et al. Low level laser therapy promotes bone regeneration by coupling angiogenesis and osteogenesis. Stem Cell Res Ther 2021;12:432.
Carla Roberta Tim, Paulo Sérgio Bossini, Hueliton Wilian Kido, Iran Malavazi, Marcia Regina von Zeska Kress, Marcelo Falsarella Carazzolle, et al. Effects of low level laser therapy on inflammatory and angiogenic gene expression during the process of bone healing: A microarray analysis. Journal of Photochemistry and Photobiology B: Biology, 2016;154:8-15.
A.S. da Rosa, A.F. dos Santos, M.M. da Silva, G.G. Facco, D.M. Perreira,
A.C.A. Alves, L. Junior, E.C. Pinto, P.d.T.C. de Carvalho. Effects of low-level laser therapy at wavelengths of 660 and 808 nm in experimental model of osteoarthritis. Photochem. Photobiol., 2012;88:161-6
T. Karu Primary and secondary mechanisms of action of visible to near-IR radiation on cells J. Photochem. Photobiol. B Biol, 1999;49:1-17
D. Hawkins, H. Abrahamse Effect of multiple exposures of low-level laser therapy on the cellular responses of wounded human skin fibroblasts Photomed. Laser Ther., 2006;24:705-714
W.-P. Hu, J.-J. Wang, C.-L. Yu, C.-C.E. Lan, G.-S. Chen, H.-S. Yu. Helium–neon laser irradiation stimulates cell proliferation through photostimulatory effects in mitochondria. J. Investig. Dermatol., 2007;127:2048-57
F.M. de Lima, A.B. Villaverde, M.A. Salgado, H.C. Castro-Faria-Neto, E. Munin, R.
Albertini, F. Aimbire Low intensity laser therapy (LILT) in vivo acts on the neutrophils recruitment and chemokines/cytokines levels in a model of acute pulmonary inflammation induced by aerosol of lipopolysaccharide from Escherichia coli in rat. J. Photochem. Photobiol. B Biol., 2010;101:271-8
F.M. deLima, A.B. Villaverde, R. Albertini, J.C. Corrêa, R.L.P. Carvalho, E. Munin, T. Araújo, J.A. Silva, F. Aimbire Dual effect of low-level laser therapy (LLLT) on the acute lung inflammation induced by intestinal ischemia and reperfusion: action on anti-and pro-inflammatory cytokines Lasers Surg. Med., 2011;43:410-20
E.M.S. Laraia, I.S. Silva, D.M. Pereira, F.A. dos Reis, R. Albertini, P. de Almeida, L.
Junior, E.C. Pinto, P.d.T.C. de Carvalho. Effect of low-level laser therapy (660 nm) on acute inflammation induced by tenotomy of Achilles tendon in rats. Photochem. Photobiol., 2012;88:1546-50
Kazem Shakouri, S., Soleimanpour, J., Salekzamani, Y. et al. Effect of low-level laser therapy on the fracture healing process. Lasers Med Sci 2010;25:73–77.
de Oliveira, G.J.P.L., Aroni, M.A.T., Pinotti, F.E. et al. Low-level laser therapy (LLLT) in sites grafted with osteoconductive bone substitutes improves osseointegration. Lasers Med Sci 2020;35:1519–29.
Fahmy, N., Abdulla, N., Khalil, M., AbdelHakim, A. Evaluation of low level laser therapy on the stability of implants using resonance frequency analysis (clinical study). Alexandria Dental Journal, 2018;43(2):94-100.
Mayer, L., Gomes, F.V., de Oliveira, M.G. et al. Peri-implant osseointegration after low-level laser therapy: micro-computed tomography and resonance frequency analysis in an animal model. Lasers Med Sci 2016;31:1789–95.
Aliaa El-hossiny Ebrahim, et al. Effect of Low-Level Laser Therapy on Osseointegration of Immediate Dental Implants in Anterior and Premolar Region. DSU — 2024;5(2):239:48.
Momeni , M., Safari, M., Sarrafzadeh, A., & Momeni, E. Effect of Low-Level Laser Therapy on the Osseointegration of Immediately Loaded Implants with a Connective Tissue Graft: A Randomized Clinical Trial: Effect of low-level laser therapy on the stability of implants. Journal of Lasers in Medical Sciences, 2024;15, e19.
Alkinan Alashhab, Isam Alkhoury, Ghaith Sahtout. A Clinical Study of the Effect of Low-Level Laser Treatment on the Clinical Stability of Immediately Loaded Implants in Posterior Maxilla. Int J Dentistry Oral Sci. 2021;08(03):1882-8.
Karakaya, M., Demirbaş, A.E. Effect of low-level laser therapy on osseointegration of titanium dental implants in ovariectomized rabbits: biomechanics and micro-CT analysis. Int J Implant Dent 2020;6:61.
Surendranath P., Arjunkumar R. Low Level Laser Therapy –A Review. IOSR-JDMS 2013;12(5):56-59
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