Efficacy of Druva Siddha Ghrita Gandusha in Management of Pittaja Mukhapaka with Special reference to Aphthous Ulcer: A Randomized Controlled Clinical Trial
DOI:
https://doi.org/10.63682/jns.v14i18S.5263Keywords:
Ayurvedic Polyherbal Drug, Gandusha, Druva Siddha Ghrita, Pittaja Mukhapaka, Triphala Siddha GhritaAbstract
Pittaja Mukhapaka is a common condition observed among patients visiting the Ear, Nose, and Throat (ENT) outpatient department. It presents with symptoms such as oral mucosal inflammation, ulceration, and a burning sensation, often linked to Aphthous ulcers (Pittaja Mukhapaka). While modern medicine offers treatments like anti-inflammatory drugs, topical corticosteroids, and tetracyclines, these options have certain limitations. In Ayurveda, Druva Siddha Ghrita is a well-known polyherbal formulation traditionally used for oral disorders. Composed of ingredients like Jati Patra, Guduchi, Draksha, Daru Haridra, Yavasa, Haritaki, Vibhitaki, Madhu, and Amalaki, this remedy is referenced in classical texts such as
Yogaratnakara and Bhaishajya Ratnavali for managing oral health issues. Materials and Methods: To assess the efficacy of Druva Siddha Ghrita in treating Mukha Rogas, a study was conducted involving 30 participants. They were randomly divided into two groups: Group A received Gandusha (oil pulling therapy) with Druva Siddha Ghrita and Madhu (honey). Group B was administered Triphala Siddha Ghrita along with Madhu. Results: Both groups showed complete relief from discomfort, burning sensations, and excessive salivation. Statistical analysis revealed a significant p-value, indicating that both treatments were equally effective. Conclusion: The study confirmed that Druva Siddha Ghrita Gandusha and Triphala Siddha Ghrita are effective in managing Pittaja Mukhapaka, providing a viable Ayurvedic alternative to conventional therapies.
Downloads
Metrics
References
Menon, Sudeep S, et al. Role of Jatamansi Taila Nardostachys Jatamansi Shiro Abhyanga on Mental Stress with Special Reference to Male Individuals. Shodhganga : a reservoir of Indian theses, 2022 http://hdl.handle.net/10603/393370
Bansal M. Disease Ear, Nose & Throat Head and Neck Surgery. 2nd ed. Jaypee Brothers; 2018. 414– 415 p.
A p h t h o u s S t o m a t i t i s : B a c k g r o u n d , Pathophysiology, Epidemiology [Internet]. [cited 2022 May 19].
Guha A. Ayurvedic Concept of Food and Nutrition. 2006 [cited 2022 May 19];1–7. Available from: https://opencommons.uconn.edu/som_articles
Hazarika P. Textbook of Ear, Nose, Throat and Head-Neck Surgery. 4th ed. CBS Publishers & Distributors; 2019. 359–360 p.
Shankar U. Netra roga. In: Shalakya Tantra. 1st ed. 2012. p. 10–25.
Hosamani RB. a review on Gandusha: an Ayurvedic Therapeutic Procedure for Oral Disorders. Int Ayurvedic Med J. 2017;1(6):746–54.
Shastri VSL. Yogaratnakar (Uttarardha), Vidyitini tika. Shastri BSB, editor. Chaukhamba Sanskrit Sansthan, Varanasi, U.P., India; 2022. 296–297 p.
Sreekumar T. Vagbhatta: Ashtanga Hrudaya with English Translation & Commentary. 2nd ed. Kavitha. Hrisree Hospital, Mannuthy. 2008. 31 p.
Ajmal M, Ibrahim L, Mohammed N, Al-Qarni H. Prevalence and psychological stress in recurrent aphthous stomatitis among female dental students in Saudi Arabia. Clujul Med [Internet]. 2018 [cited 2022 May 20];91(2):216–21.
Vinitha V Nair, Rajashekhara N KB. Clinical evaluation of Ashvattha (Ficus religiosa Linn.) in Mukhapaka with special reference to aphthous ulcer. J Ayurvedic Herb Med. 2015;1(3):77–80.
Sembulingam K, Sembulingam P. Essentials of Medical Physiology. 6th ed. Jaypee Brothers Medical publisher; 2012. 226–228 p.
Dhulappa M, Ashok WG. Experimental Study of Jati Patra (Jasminum Grandiflorum Linn) W. S. R. to its Vrana Ropana (Wound Healing Activity). Int Ayurvedic Med J. 2013;1(6):77–84.
Arun M, Satish S, Anima P. Phytopharmacological Profile of Jasminum grandiflorum Linn. (Oleaceae). Chinese J Integr Med 2015 224 [Internet]. 2015 Apr 6 [cited 2022 May 20];22(4):311–20.
Umamaheswari M, Asokkumar K, Rathidevi R, Sivashanmugam AT, Subhadradevi V, Ravi TK. Antiulcer and in vitro antioxidant activities of Jasminum grandiflorum L. J Ethnopharmacol [Internet]. 2007 Apr 4 [cited 2022 May 20];110(3):464–70
Upadhyay A, Kumar K, Kumar A, Mishra H. Tinospora cordifolia (Willd.) Hook. f. and Thoms. ( Guduchi) - validation of the Ayurvedic pharmacology through experimental and clinical studies. Int J Ayurveda Res. 2010;1(2):112.
Saha S, Ghosh S. Tinospora cordifolia: One plant, many roles. Anc Sci Life. 2012;31(4):151.
Kotadiya J, Rathva B, Upadhyay U. Guduchi: A Potential Drug in Ayurveda. Int J Pharm Res Appl. 2020;5(2):595–605.
Rawat N, Roushan R. Ayurvedic Management of Trigeminal neuralgia: A Case Report. Int J Res Ayurveda Pharm [Internet]. 2018 Sep 8;9(4):59–61.
Asnaashari S, Dastmalchi S, Javadzadeh Y. Gastroprotective effects of herbal medicines (roots). Int J Food Prop [Internet]. 2018 Jan 1;21(1):902– 20.
Choudhary S, Kaurav H, S. M, Chaudhary G. Daruharidra (Berberis aristata): Review based upon its Ayurvedic Properties. Int J Res Appl Sci Biotechnol. 2021 Mar;8(2):98–106.
Mazumder PM, Das S, Das S, Das MK. Phyto- pharmacology of berberis aristata DC: A Review. J Drug Deliv Ther. 2011 Dec 10;1(2):46–50.
Ingale A, Pinnelli V, Rajendran V. Experimental evaluation of the anti-ulcer activity of the ethanolic extract of grape (Vitis vinifera) seed in wistar albino rats against aspirin plus pylorus ligation induced gastric ulcer model. Int J Basic Clin Pharmacol. 2016;5(3):722–7.
Singh L, HV R. A Clinical Study in the management of Garbhini Pandu with Draksha Ghrita w.s.r. to Iron Deficiency Anaemia in Pregnancy. J Ayurveda Integr Med Sci. 2020 Oct 25;5(05):21–30.
Deepashri T, Kumari S. Literature review of Draksha (Vitis vinifera). Int Ayurvedic Med J. 2017;5(2):545–8.
Kumar Ghodela N, Tukaram Dudhamal C, Dudhamal T. Wound healing potential of Ayurved herbal and herbo-mineral formulations: A brief review. Int J Herb Med. 2017;5(1):39–45
Samarghandian S, Farkhondeh T, Samini F. Honey and Health: A Review of Recent Clinical Research. Pharmacognosy Res. 2017 Apr 1;9(2):121.
Pasupuleti VR, Sammugam L, Ramesh N, Gan SH. Honey, Propolis, and Royal Jelly: A Comprehensive Review of Their Biological Actions and Health Benefits. Oxid Med Cell Longev. 2017;2017:1–21.
El-Haddad SA, Asiri FY, Al-Qahtani HH, Al- Ghmlas AS. Efficacy of honey in comparison to topical corticosteroid for treatment of recurrent minor aphthous ulceration: a randomized, blind, controlled, parallel, double-center clinical trial. Quintessence Int [Internet]. 2014 Sep;45(8):691– 701.
Mohamed S, Al-Douri A. The Effect of Honey on the Healing of Oral Ulcers (Clinical Study). Al- Rafidain Dent J [Internet]. 2008 Sep 1;8(2):157–60.
Ratha K, Joshi G. Haritaki (Chebulic myrobalan) and its varieties. AYU (An Int Q J Res Ayurveda). 2013;34(3):331.
Gupta A, Kumar R, Bhattacharyya P, Bishayee A, Pandey AK. Terminalia bellirica (Gaertn.) roxb. (Bahera) in health and disease: A systematic and comprehensive review. Phytomedicine. 2020 Oct 1;77:153278.
Gupta S, Kalaiselvan V, Srivastava S, Agrawal S, Saxena R. Evaluation of anticataract potential of Triphala in selenite-induced cataract: In vitro and in vivo studies. J Ayurveda Integr Med [Internet]. 2010;1(4):280.
Bhat Scholar PM, Professor A, Umale Professor H, Lahankar Professor M, Pravin Bhat Scholar CM, Bhat PM, et al. Amalaki: A review on functional and pharmacological properties. J Pharmacogn Phytochem. 2019;8(3):4378–82.
Kumar V, Aneesh kumar A, Kshemada K, Ajith KGS, Binil RSS, Deora N, et al. Amalaki rasayana, a traditional Indian drug enhances cardiac mitochondrial and contractile functions and improves cardiac function in rats with hypertrophy. Sci Rep [Internet]. 2017 Dec 17;7(1):8588.
Downloads
Published
How to Cite
Issue
Section
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
You are free to:
- Share — copy and redistribute the material in any medium or format
- Adapt — remix, transform, and build upon the material for any purpose, even commercially.
Terms:
- Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
