Development and Characterization of Minocycline Loaded Elastic Liposomal Gel for Effective Treatment of Skin Disease
Keywords:
Elastic liposomes, liposomal gel, drug delivery, vesicle size, entrapment efficiency, sustained release, skin disease treatment, stability, in-vitro drug release, transdermal deliveryAbstract
The study aimed to develop and evaluate elastic liposomal gel formulations for the effective delivery of therapeutic agents to treat skin diseases. Various formulations of elastic liposomes were prepared, and their vesicle size, entrapment efficiency, and stability were assessed. The optimized formulation (F4) exhibited the smallest vesicle size (135.25 nm) and the highest entrapment efficiency (76.65%). Additionally, the corresponding elastic liposomal gel formulation (ELG2) was evaluated for drug content, pH, spreadability, and viscosity. ELG2 exhibited good drug content (98.85%), skin-friendly pH (6.82), and desirable spreadability (12.65 gm.cm/sec.). In-vitro drug release studies revealed that ELG2 demonstrated a sustained release profile, with 96.65% of the drug released at 10 hours. The release kinetics followed zero-order and Korsmeyer-Peppas models, indicating a controlled release mechanism. Stability studies confirmed the long-term stability of ELG2, with minimal changes in drug content and viscosity at both 4°C and 28°C. These results highlight the potential of the developed elastic liposomal gel for effective and stable drug delivery, making it a promising formulation for the treatment of dermatological conditions.
Downloads
Metrics
References
Bui, N., Vo, N., & Nguyen, D. (2014). Minocycline: An overview of its clinical use. Journal of Dermatological Treatment, 25(4), 292-296.
Touitou, E., Dayan, N., Bergelson, L., & Godin, B. (2000). Ethosomes—novel vesicular carriers for enhanced delivery: Characterization and skin penetration properties. Journal of Controlled Release, 65(3), 403-418.
Zouboulis, C. C. (2009). Acne and sebaceous gland. Dermatology Clinics, 27(2), 95-105. doi:10.1016/j.det.2009.01.008
Badan, G. M., Costa, D., & Camargo, A. (2015). Topical delivery of drugs in the treatment of skin diseases: Advantages and challenges. International Journal of Pharmaceutical Sciences and Research, 6(5), 1885-1893.
Touitou, E., Dayan, N., Bergelson, L., Godin, B. & Eliaz, M. (2000) Ethosomes -Novel vesicular carriers for enhanced delivery: Characterization and skin penetration properties. Journal of Controlled Release, 65, 403–418.
Hussain, A., Samad, A., Ramzan, M., Ahsan, M.N., Ur Rehman, Z. & Ahmad, F.J. (2016) Elastic liposome-based gel for topical delivery of 5-fluorouracil: In vitro and in vivo investigation. Drug Delivery, 23, 1115–1129.
Maurya, S.D., Prajapati, S.K., Gupta, A.K., Saxena, G.K. & Dhakar, R.C. (2010) Formulation development and evaluation of ethosome of stavudine. Indian Journal of Pharmaceutical Education and Research, 44, 102–108.
Utreja, P., Jain, S. & Tiwary, A.K. (2011) Localized delivery of paclitaxel using elastic liposomes: Formulation development and evaluation. Drug Delivery, 18, 367–376.
Nava, G., Pinon, E., Mendoza, L., Mendoza, N., Quintanar, D. & Ganem, A. (2011) Formulation and in vitro, ex vivo and in vivo evaluation of elastic liposomes for transdermal delivery of ketorolac tromethamine. Pharmaceutics, 3, 954–970.
Kamra, M., Diwan, A. & Sardana, S. (2017) Topical liposomal gel: A review. International Journal of Pharmaceutical Sciences and Research, 8, 2408–2414.
Leno Jenita, J.J., Madhusudhan, N.T. & Wilso, B. (2012) N, Manjula. D SBK. Formulation development and evaluation of. World Journal of Pharmaceutical Research, 1, 207–215.
Princely S, Dhanaraju Md. Design, formulation, and characterization of liposomal-encapsulated gel for transdermal delivery of Fluconazole (2018). Asian Journal of Pharmaceutical and Clinical Research, 11, 417.
Multimer M. Spreadability determination by an apparatus (1956). American Pharmacy, (Asso), 45, 212–218.
Downloads
Published
How to Cite
Issue
Section
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
You are free to:
- Share — copy and redistribute the material in any medium or format
- Adapt — remix, transform, and build upon the material for any purpose, even commercially.
Terms:
- Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
