Formulation and Evaluation of Lacidipine Loaded Emulgel
Keywords:
Lacidipine, Emulgel, Transdermal Drug Delivery, Controlled Release, Carbopol 934P, In-vitro Drug ReleaseAbstract
The present study focuses on the formulation and evaluation of lacidipine-loaded emulgel designed for effective transdermal drug delivery. Lacidipine, a calcium channel blocker with poor aqueous solubility and extensive first-pass metabolism, presents a challenge for conventional oral delivery. To overcome these limitations, an emulgel formulation was developed combining the advantages of emulsions and gels, aiming for enhanced solubility, controlled release, and improved patient compliance. Eight formulations (F1–F8) were prepared using Carbopol 934P as the gelling agent and evaluated for physicochemical properties, drug content, pH, viscosity, spreadability, extrudability, and in-vitro drug release. Among them, Formulation F3 demonstrated optimal characteristics, with a pH of 6.72 ± 0.03, drug content of 97.88 ± 0.32%, and cumulative drug release of 86.53% over 240 minutes, following first-order release kinetics (R² = 0.9826). The results suggest that the optimized emulgel provides a sustained release profile suitable for transdermal administration, offering a promising alternative to oral delivery of lacidipine by enhancing bioavailability and reducing dosing frequency.
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