Unexpected Culprit: A case of Acetaminophen induced SJS-TEN in a young child
Keywords:
Corticosteroids, Drug Hypersensitivity, Pediatric Dermatology, Toxic Epidermal Necrolysis, Stevens–Johnson Syndrome, AcetaminophenAbstract
Stevens–Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are rare but potentially life-threatening mucocutaneous reactions most often triggered by medications such as antibiotics or anticonvulsants. Acetaminophen, a commonly used antipyretic in pediatric practice, is an uncommon but documented cause. We present a rare case of SJS-TEN overlap in a 2-year-old boy following acetaminophen administration, involving approximately 25% of the body surface area. Prompt discontinuation of the offending drug, coupled with supportive care and early corticosteroid therapy, led to complete recovery without complications. This case underscores the importance of clinical vigilance and timely intervention, even with routinely prescribed medications in children
Downloads
Metrics
References
Wang L, Varghese S, Bassir F, Lo YC, Ortega CA, Shah S, et al. Stevens-Johnson syndrome and toxic epidermal necrolysis: A systematic review of case reports from 1980 to 2020. Front Med (Lausanne). 2022;9:949520.
Indian Academy of Pediatrics (IAP). Standard Treatment Guidelines 2022 – Stevens–Johnson Syndrome/Toxic Epidermal Necrolysis.
Antoon JW, Goldman JL, Lee B, Schwartz A. Incidence, outcomes, and resource use in children with Stevens-Johnson syndrome and toxic epidermal necrolysis. Pediatr Dermatol. 2018;35(2):182–187.
Rajput R, Sagari S, Durgavanshi A, Kanwar A. Paracetamol-induced Steven-Johnson syndrome: A rare case report. Contemp Clin Dent. 2015;6(Suppl 1):S260–3.
Khor AH, Lim KS, Tan CT, Kwan Z, Tan WC, Wu DB, et al. HLA-A31:01 and HLA-B15:02 association with Stevens-Johnson syndrome and toxic epidermal necrolysis to carbamazepine in a multiethnic Malaysian population. Pharmacogenet Genomics. 2017;27(7):275–278.
Prajapat M, Shetty S, Panda PK, Suresh P. Management of Stevens-Johnson Syndrome-Toxic Epidermal Necrolysis: Looking Beyond Guidelines. J Pharmacol Pharmacother. 2018;9(1):1–7.
Hsu DY, et al. Pediatric Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in the United States. J Am Acad Dermatol. 2017;76(5):811–817.e4.
Paulmann M, Mockenhaupt M. Fever in Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Pediatric Cases: Laboratory Work-up and Antibiotic Therapy. Pediatr Infect Dis J. 2017;36(5):513–515.
.
Downloads
Published
How to Cite
Issue
Section
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
You are free to:
- Share — copy and redistribute the material in any medium or format
- Adapt — remix, transform, and build upon the material for any purpose, even commercially.
Terms:
- Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
