Kimura Disease – A Rare Cause of Chronic Swelling and Inflammation
Keywords:
Kimura Disease, Lymphadenopathy, Eosinophilia, Radiological evaluationAbstract
Kimura Disease (KD) is a rare, benign chronic inflammatory condition characterized by painless subcutaneous nodules, lymphadenopathy, eosinophilia, and elevated serum IgE levels. This report describes a 35-year-old female with a painless left-sided head and neck mass. Diagnosis was confirmed by clinical, radiological, and histopathological evaluation. Due to its overlapping features with malignancy and other inflammatory conditions, timely recognition of KD is essential for proper management.
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Ohta N, Furukawa M, Fukase S, Suzuki Y, Ishida A, Aoyagi M. Kimura’s disease: possible link between allergic reaction and lymphoid neogenesis. Am J Otolaryngol. 2010;31(5):321–6. [PMID: 19709849]
Lin J, Wang S, Deng J, Li X, Zhang L, Wang L. The role of eosinophils in Kimura disease: a case report and literature review. J Int Med Res. 2020;48(7):0300060520937783. [PMID: 32715896]
Yamada A, Watanabe F, Hashimoto T, Kato A, Hoshino T, Arimura K. Immunopathological study of Kimura disease: cytokine expression and IgE deposition analysis. Pathol Int. 2018;68(5):275–83. [PMID: 29691877]
Zhang L, Zhang X, Zhang H, Zhang S. Kimura’s disease with multiple subcutaneous masses in the head and neck: a case report and literature review. BMC Dermatol. 2021;21(1):7. [PMID: 33888165]
Lin SH, Wu CY, Chen YL, Wu YH. Kimura’s disease: A case report and literature review. J Formos Med Assoc. 2019;118(3):738–41. [PMID: 30583979]
Ramchandani PL, Sabesan T, Hussein K. Kimura’s disease: an unusual cause of head and neck masses. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2005;99(6):683–92. [PMID: 15953906]
Lee BJ, Kim JH, Kim WS, Kim SH, Kim JH. Imaging findings in Kimura’s disease: emphasis on MR imaging. Am J Neuroradiol. 2005;26(8):2128–33. [PMID: 16091513]
Googe PB, Harris NL, Mihm MC Jr. Kimura’s disease and angiolymphoid hyperplasia with eosinophilia: two distinct histopathologic entities. Am J Surg Pathol. 1987;11(9):756–64. [PMID: 3625663]
Wei P, Wang Y, Tang Y, Yao X, Xu X. Kimura’s disease: a clinicopathological study of 45 cases at a single institution. Int J Clin Exp Pathol. 2019;12(5):1779–85. [PMID: 31949626]
Guo R, Gavino AC. Kimura’s disease and angiolymphoid hyperplasia with eosinophilia. Arch Pathol Lab Med. 2015;139(6):826–8. [PMID: 26030242]
Ye P, Wen Y, Jin P, Lin Y. Kimura’s disease: a case report and literature review. Medicine (Baltimore). 2022;101(30):e29747. [PMID: 35876976]
Li J, Zhou J, Li C, Wang S. Kimura’s disease: a chronic inflammatory disorder associated with angiogenesis. Clin Chim Acta. 2020;508:91–7. [PMID: 31901464]
Kottler D, Barlogis V, Farnarier C, et al. Kimura disease: retrospective study of 21 pediatric cases and proposal of a therapeutic strategy. J Am Acad Dermatol. 2016;75(4):822–9. [PMID: 27474245]
Goto M, Koyama H, Matsumoto K, et al. Successful treatment of Kimura’s disease with omalizumab. Allergol Int. 2022;71(1):129–31. [PMID: 34626894]
Lee CC, Feng IJ, Chen YT, et al. Treatment algorithm for Kimura’s disease: a systematic review and meta-analysis of treatment modalities and prognostic predictors. Int J Surg. 2022;100:106591. [PMID: 35395391]
Sun QF, Xu DZ, Pan SH, et al. Kimura disease: review of the literature. Intern Med J. 2008;38(8):668–72. [PMID: 18691371]
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