Systematic Review of MRg-HIFU as a Treatment for Osteoid Osteoma: Evaluating its Effectiveness and Clinical Applicability
Keywords:
Systematic Review, MRgFUS, Osteoid osteomaAbstract
Introduction: Osteoid osteoma is a small size, primary bone tumor associated with localized pain worsen at night disturbing sleep and affect life quality. Magnetic resonance-guided focused ultrasound (MRgFUS) has been recently used for osteoid osteoma and claimed to be superior to other treatment methods. However, its feasibility and efficiency still need to be precisely evaluated on a large scale to confirm its superiority and feasibility. This systematic review aimed to assess the MRgFUS feasibility and efficiency for osteoid osteoma ablation based on the success rate and complication in addition to its suitability to the different age groups.
Methods: A detailed search in websites including PubMed, Web of science, and Cochrane Library databases was conducted to screen the related literature to analyze data according (PRISMA) This analysis included the success rates (absence of pain at end of follow-up period), tumor recurrence rate, secondary intervention rate and ratio of complications if present in addition to the patients median age.
Results: Out of identified 217 studies in the data base a total of 12 studies published between 2013 and 2021 were assigned for inclusion. These studies varied between prospective, retrospective, clinical trials, case series and clinical observational cohort and included 503 patients. The period of post-treatment follow-up ranged between 4 weeks to 3 years, the ages of the treated patients varied from children to aged patients over 80 years and the majority of the osteoid osteoma distribution was 51.8 % in the femur followed by 14.5%, 11.39%, 10.88%, and 51.8% in the tibia, hand/foot, ankle and humorous respectively. The success rate of the combination was 91.4% (95% CI: 88.8%–93.5.7%) with a minor complications incidence (heat burn at the ablation site probe paths) in a rate was 0.65% with absence of recorded major complications.
Conclusion: MRgHIFU is a promising technique and can be an excellent clinical and feasible choice for osteoid osteoma ablation based on its high acoustic absorption of the bone tissue and its superiority over other therapeutics, being noninvasive, associated with high success rate and minor complication especially.
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