Study Of Biological Activity And Safety Of Phytocomposition Of Antidiabetol
Keywords:
Diabetes mellitus, Phytocomposition, Antidiabetol, Hypoglycemic effect, Antidiabetic effectAbstract
Objective: Modern lifestyles often lead to an imbalance between energy intake and expenditure, contributing to obesity, which is a major risk factor for type II diabetes. The consumption of unhealthy foods, high in refined sugars and unhealthy fats, leads to insulin resistance, where the body's cells do not respond effectively to insulin.
Methods: The acute toxicity, allergenic, diuresis, immune system, hypoglycemic effect, course of experimental alloxan diabetes of the Antidiabetol capsule. In diabetes, the influence of Antidiabetol on the immune system and on diuresis plays a significant role. The study of the impact of Antidiabetol on the immune system was conducted using the Jerne and Nordin method, while the effect on diuresis was studied using the method of V.V. Gatsura.
Results: This resistance is a precursor to type II diabetes. Additionally, chronic stress can impact hormone levels and metabolism, further exacerbating the risk of developing diabetes. Stress often leads to poor dietary choices and reduced physical activity, creating a cycle that contributes to weight gain and insulin resistance. Harmful habits, such as smoking and excessive alcohol consumption, also play a role in the development of diabetes. These behaviors can damage the body's systems and contribute to metabolic dysfunction.
Conclusion: The study is concluded to investigate the safety and hypoglycemic activity of the “Antidiabetol” capsule.
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Asfandiaryova, N.S. Mortality in type 2 diabetes. Diabetes Mellitus. 2015;18(4):12-21.
Dedov, I.I., Shestakova, M.V. Algorithms for specialized medical care for patients with diabetes mellitus. Diabetes Mellitus. 2017; 20(IS):1-112.
Dedov, I.I., Shestakova, M.V. Algoritmy spetsializirovannoy meditsinskoy pomoshchi bol’nim sakharnym diabetom [Algorithms for specialized medical care for patients with diabetes]. Diabetes Mellitus. 2017;20(IS):1-112.
Marchetti P, Bugliani M, Boggi U, Masini M, Marselli L. The pancreatic β cells in human type 2 diabetes. Adv Exp Med Biol. 2012;771:288-309.
Meier JJ, Bonadonna RC. Role of reduced β-cell mass versus impaired β-cell function in the pathogenesis of type 2 diabetes. Diabetes Care. 2013;36 (Supplement 2): S113-S119.
Saisho Y. β-cell dysfunction: Its critical role in prevention and management of type 2 diabetes. World Journal of Diabetes. 2015;6(1):109.
Shah AD, Langenberg C, Rapsomaniki E, Denaxas S, Pujades-Rodriguez M, Gale CP, et al. Type 2 diabetes and incidence of cardiovascular diseases: a cohort study in 19 million people. Lancet Diabetes Endocrinol. 2015;3(2):105-13.
Shi Y, Vanhoutte PM. Macro- and microvascular endothelial dysfunction in diabetes. Journal of Diabetes. 2017;9:434-49.
Vergès B. Pathophysiology of diabetic dyslipidaemia: where are we? Diabetologia. 2015;58(5):886-99.
Wright EM, Loo DD, Hirayama BA. Biology of human sodium glucose transporters. Physiological Reviews. 2011;91(2):733-94.
Mukesh R, Namita P. Medicinal Plants with Antidiabetic Potential-A Review. American-Eurasian J Agric Environ Sci. 2013; 13(1): 81-94.
Osadebe PO, Odoh EU, Uzor PF. The search for new hypoglycemic agents from plant. Afr J Pharm Pharmacol. 2014; 8(11): 292-303.
Kambarov, Kh.Dz. Development of technology for cardiovascular and sedative drugs based on local medicinal plant raw materials: Author's abstract of dissertation for the degree of Doctor of Pharmaceutical Sciences: 15.00.01. Tashkent Pharmaceutical Institute. Tashkent; 2016; 50 p.
Faizieva, Z.T. Pharmacology of biologically active substances isolated from Stevia rebaudiana B., Rhodiola semenovii A., and Helianthus tuberosus L.: Dissertation abstract for the degree of Doctor of Medical Sciences: 14.00.25. Tashkent Pharmaceutical Institute. Tashkent; 2011; 31 p.
Feruza Saydaliyeva , Ziyoda Fayzieva, Natalya Shiltsova. Pharmako-toxicological actions of liquid extract “Hemostat”. World Bulletin of Public Healht. 2022; 8:120-125.
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