Effectiveness of Empirical Hormonal Stimulation in the Treatment of Idiopathic Oligoasthenoteratospermia: A Clinical Evaluation
Keywords:
Empirical Hormonal, infertility, motility, idiopathic oligospermia, sperm morphologyAbstract
Background: Instead of distinct forms, DNA fragmentation and chromatin structural abnormalities are connected to most occurrences of idiopathic oligoasthenoteratospermia (OAT). Hormonal treatment dosage and duration varies amongst proposed strategies. Testicular testosterone (TT), which is transformed into dihydrotestosterone (DHT), and gonadotropins are stimulated by gonadotropin-releasing hormone (GnRH) pulses. DHT raises the concentration of TT for spermatogenesis via promoting the synthesis of androgen-binding protein (ABP) in Sertoli cells.
Aim: to assess how well sperm parameters (such as count, motility, and morphology) are improved by empirical hormonal stimulation.
Subjects And Methods: The study included a sample of 15 male patients diagnosed with idiopathic oligoasthenoteratospermia. These patients were selected conveniently from those attending the infertility clinic at AL-Yarmouk –Teaching Hospital.
Results: Sperm concentration increased slightly from 5.334 ± 1.794 × 106/ml before treatment to 6.067 ± 1.885 × 106/ml after treatment, and the percentage of normal sperm morphology increased from 0.933% ± 1.1 before treatment to 3.6% ± 8.781 after treatment (P = 0.002). Prior to therapy, the total sperm count was 13.794 ± 3.374 × 106/ml; following treatment, it increased to 17.156 ± 9.225 × 106/ml (P = 0.042).
Conclusion: The percentage of normal sperm morphology increased significantly after hormonal treatment (P = 0.002). Sperm quality improved as evidenced by a significant drop in aberrant sperm shapes (P = 0.049).
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Aljuhayman A, Almardawi A, Fallatah M, Alhathal N. Efficacy of follicle-stimulating hormone as a treatment of severe idiopathic oligospermia: A retrospective study. 2020. ncbi.nlm.nih.gov
Choudhary S, Mishra V, Kumari P, Sheth H et al. Male Infertility: Causes and Management at a Tertiary Care Center in India. 2023. ncbi.nlm.nih.gov
Sharma A, Minhas S, Dhillo WS, Jayasena CN. Male infertility due to testicular disorders. The Journal of Clinical Endocrinology & Metabolism. 2021 Feb 1;106(2):e442- 59. nih.gov
Matsuyama S, DeFalco T. Steroid hormone signaling: multifaceted support of testicular function. 2024. ncbi.nlm.nih.gov.
O. Oduwole O, Peltoketo H, T. Huhtaniemi I. Role of Follicle-Stimulating Hormone in Spermatogenesis. 2018. ncbi.nlm.nih.gov
Desai A, Yassin M, Cayetano A, Tharakan T, Jayasena CN, Minhas S. Understanding and managing the suppression of spermatogenesis caused by testosterone replacement therapy (TRT) and anabolic–androgenic steroids (AAS). Therapeutic Advances in Urology. 2022 Jun;14:17562872221105017. sagepub.com
Fowell DJ, Kim M. The spatio-temporal control of effector T cell migration. Nature Reviews Immunology. 2021. nih.gov
Meccariello R, Chianese R, Chioccarelli T, Ciaramella V et al. Intra-Testicular Signals Regulate Germ Cell Progression and Production of Qualitatively Mature Spermatozoa in Vertebrates. 2014. ncbi.nlm.nih.gov.
Çayan S, Altay AB, Rambhatla A, Colpi GM, Agarwal A. Is There a Role for Hormonal Therapy in Men with Oligoasthenoteratozoospermia (OAT)?. Journal of Clinical Medicine. 2024 Dec 31;14(1):185. mdpi.com.
Agarwal A, Mulgund A, Hamada A, Chavarro J. Human sperm morphology: a critical review of clinical implications of the abnormal sperm form. Fertility and Sterility. 2015;103(1):11-19.
Moursy E, Osman A, Abou-Salem N. The effect of hormonal therapy on sperm morphology and other semen parameters in men with idiopathic infertility. Andrologia. 2013;45(2):121-128.
Colombo M, Ferrera P, Caruso A, et al. Hormonal treatment for idiopathic male infertility: review of the literature. Journal of Reproductive Medicine. 2016;61(4):153-162.
Ciftci H, Yilmaz N, Ozcan C, et al. Effects of hormonal therapy on semen parameters in male infertility: a comprehensive review. Journal of Urology. 2014;192(4):1063-1070.d
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