Comparative Study on Crp An Inflammatory Biomarkers in Type 2 Diabetes Mellitus

Authors

  • Sahaya Merina A
  • Kiruthika N
  • Rani Thankam V. S
  • Angel Varghese
  • Senthil Kumar T
  • Thulasi Raman K

Keywords:

CRP, Diabetes, Increased CRP, Inflammation, Biomarker, hs-CRP

Abstract

Background:The main objective of this study is to prove that CRP level is higher in T2DM cases comparing to non- diabetic which may lead to heart disease among the patients

Methods: A cross-sectional study was conducted from November 2023 to May 2024, using the blood samples of the patients of type II diabetes mellitus patients, analysed in Agappe nephlometer for CRP and Beckman coulter AU480 for blood sugar and HbA1c.

Results:A total of 100 patients samples are taken for Hba1c, CRP, FBS&PPBS for the study of High level CRP in Diabetic Patients. Out of the 100 apparently (Diabetic 50 sample Non-Diabetic 50 sample) patients

Conclusions:The study concludes that the Type II Diabetes Mellitus patients have increased Crp level than the Non-Diabetic patients.It can be concluded from the study that raised levels of plasma CRP in type 2 diabetic patients may contribute to ongoing atherosclerotic processes leading to the development of coronary heart disease in these patients and this can be used as a early marker of development of atherosclerosis in patients with diabetes mellitus.

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References

Ali S, Khan MA, Khan MA. CRP, an Inflammatory biomarker in type 2 Diabetes mellitus. J Postgrad Med Inst 2015; 29(1): 18-23.

A. K. Shrivastava, H. V. Singh, A. Raizada, and S. K. Singh, “C-reactive protein, inflammation and coronary heart disease,” The Egyptian Heart Journal, vol. 67, no. 2, pp. 89–97, 2015

A. M. Dupuy, S. Badiou, B. Descomps, and J. P. Cristol, “Immunoturbidimetric determination of C-reactive protein (CRP) and high-sensitivity CRP on heparin plasma. Comparison with serum determination,” Clinical Chemistry and Laboratory Medicine, vol. 41, no. 7, pp. 948-949, 2003.

Al Harithy, R.N.; Al Ghamdi, S. Serum resistin, adiposity and insulin resistance in Saudi women with type 2 diabetes mellitus. Ann. Saudi Med. 2005, 25, 283–287.

Agho ET, Owotade FJ, Kolawole BA, Oyetola EO, Adedeji TA. Salivary inflammatory biomarkers and glycated haemoglobin among patients with type 2 diabetic mellitus. BMC Oral Health. 2021 Mar 6;21(1):101. doi: 10.1186/s12903-021-01453-y. PMID: 33676486; PMCID: PMC8095344.

Bell DS: Inflammation, insulin resistance, infection, diabetes, and atherosclerosis. Endocr Pract 6:272–276, 2000.

Badawi A, Klip A, Haddad P, Cole DE, Bailo BG, El-Sohemy A, Karmali M. Type 2 diabetes mellitus and inflammation: Prospects for biomarkers of risk and nutritional intervention. Diabetes Metab Syndr Obes. 2010;3:173-186.

Bazzano LA, He J, Muntner P, Vupputuri S, Whelton PK: Relationship between cigarette smoking and novel risk factors for cardiovascular disease in the United States. Ann Intern Med 138:891–897, 2003

Calle MC, Fernandez ML: Inflammation and type 2 diabetes. Diabetes Metab 2012, 38(3):183–91.

Duncan, B. B. et al. Low-grade systemic infammation and the development of type 2 diabetes. Diabetes. 52, 1799–1805 (2003).

Dehghan A, van Hoek M, Sijbrands EJ, Stijnen T, Hofman A, Witteman JC. Risk of type 2 diabetes attributable to C-reactive protein and other risk factors. Diabetes Care. 2007 Oct;30(10):2695-9. doi: 10.2337/dc07-0348. Epub 2007 Jul 10. PMID: 17623828.

Dregan A, Charlton J, Chowienczyk P, Gulliford MC. Chronic inflammatory disorders and risk of type 2 diabetes mellitus, coronary heart disease, and stroke: a population-based cohort study. Circulation. 2014 Sep 2;130(10):837-44. doi: 10.1161/CIRCULATIONAHA.114.009990. Epub 2014 Jun 26. PMID: 24970784.Elimam H, Abdulla AM, Taha IM. Inflammatory markers and control of type 2 diabetes mellitus. Diabetes Metab Syndr. 2019 Jan-Feb;13(1):800-804. doi: 10.1016/j.dsx.2018.11.061. Epub 2018 Dec 3. PMID: 30641811.

Devaraj S, Rogers J, Jialal I. Statins and biomarkers of inflammation. Curr Atheroscler Rep 2007;9(1):33–41Hu FB, Meigs JB, Li TY, Rifai N, Manson JE. Inflammatory markers and risk of developing type 2 diabetes in women. Diabetes. 2004 Mar;53(3):693-700. doi: 10.2337/diabetes.53.3.693. PMID: 14988254.Kumari, Renu1,; Singh, Harkaran1. The prevalence of elevated high-sensitivity C-reactive protein in normal pregnancy and gestational diabetes mellitus. Journal of Family Medicine and Primary Care 6(2):p 259-264, Apr–Jun 2017. | DOI: 10.4103/2249-4863.219995

Haverkate F, Thompson SG, Pyke SD, Gallimore JR, Pepys MB: Production of Creactive protein and risk of coronary events in stable and unstable angina: European Concerted Action on Thrombosis and Disabilities Angina Pectoris Study Group. Lancet 349:462–466, 1997

Kanmani, S., Kwon, M., Shin, MK. et al. Association of C-Reactive Protein with Risk of Developing Type 2 Diabetes Mellitus, and Role of Obesity and Hypertension: A Large Population-Based Korean Cohort Study. Sci Rep 9, 4573 (2019). https://doi.org/10.1038/s41598-019-40987-8

kumar, S. S.; Parag, R. Factors of Raised C-Reactive Protein As a Potential Determinant of Diabetic Patients and Risk Factor for Coronary Heart Disease. ijmsci 2018, 5, 3656-3661.

Lee CC, Adler AI, Sandhu MS, Sharp SJ, Forouhi NG, Erqou S, Luben R, Bingham S, Khaw KT, Wareham NJ. Association of C-reactive protein with type 2 diabetes: prospective analysis and meta-analysis. Diabetologia. 2009 Jun;52(6):1040-7. doi: 10.1007/s00125-009-1338-3. Epub 2009 Mar 27. PMID: 19326095.

Low Wang CC, Hess CN, Hiatt WR, Goldfine AB. Clinical Update: Cardiovascular Disease in Diabetes Mellitus: Atherosclerotic Cardiovascular Disease and Heart Failure in Type 2 Diabetes Mellitus - Mechanisms, Management, and Clinical Considerations. Circulation. 2016 Jun 14;133(24):2459-502. doi: 10.1161/CIRCULATIONAHA.116.022194. PMID: 27297342; PMCID: PMC4910510.Nakanishi S, Yamane K, Kamei N, Okubo M, Kohno N. Elevated C-reactive protein is a risk factor for the development of type 2 diabetes in Japanese Americans. Diabetes Care. 2003 Oct;26(10):2754-7. doi: 10.2337/diacare.26.10.2754. PMID: 14514575.Pan, A., Wang, Y., Yuan, JM. et al. High-sensitive C-reactive protein and risk of incident type 2 diabetes: a case–control study nested within the Singapore Chinese Health Study. BMC Endocr Disord 17, 8 (2017). https://doi.org/10.1186/s12902-017-0159-5

Mendall MA, Patel P, Ballam L, Strachan D, Northfield TC. C reactive protein and its relation to cardiovascular risk factors: a population based cross sectional study. Br Med J 1996; 312:1061–5.

Pannacciulli, N. & De Pergola, G. A family history of Type 2 diabetes is associated with increased plasma levels of C-reactive protein in non smoking healthy adult women. Diab Med. 19, 689–692 (2002).

Ridker P, Buring J, Shih J, Matias M, Hennekens C. Prospective study of c-reactive protein and the risk of future cardiovascular events among apparently healthy women. Circ 1998; 98: 731-733.

Samaropoulos XF, Light L, Ambrosius WT, Marcovina SM, Probstfield J, Goff DC Jr. The effect of intensive risk factor management in type 2 diabetes on inflammatory biomarkers. Diabetes Res Clin Pract. 2012 Mar;95(3):389-98. doi:1016/j.diabres .2011.09.027. Epub 2011 Oct 22. PMID: 22019270.

Stanimirovic J, Radovanovic J, Banjac K, Obradovic M, Essack M, Zafirovic S, Gluvic Z, Gojobori T, Isenovic ER. Role of C-Reactive Protein in Diabetic Inflammation. Mediators Inflamm. 2022 May 17;2022:3706508. doi: 10.1155/2022/3706508. PMID: 35620114; PMCID: PMC9129992.

Snijder, M. B. et al. Prospective relation of C-reactive protein with type 2. diabetes. Diab Care. 26, 1656–1657 (2003)

Schaumberg DA, Glynn RJ, Jenkins AJ, Lyons TJ, Rifai N,Manson JE, et al. Effect of intensive glycemic control on levels of markers of inflammation in type 1 diabetes mellitus in the Diabetes Control and Complications Trial.Circulation 2005;111:2446–53.

Thorand B, Löwel H, Schneider A, Kolb H, Meisinger C, Fröhlich M, Koenig W. C-reactive protein as a predictor for incident diabetes mellitus among middle-aged men: results from the MONICA Augsburg cohort study, 1984-1998. Arch Intern Med. 2003 Jan 13;163(1):93-9. doi: 10.1001/archinte.163.1.93. PMID: 12523922.

Vinagre, I., Sánchez-Quesada, J.L., Sánchez-Hernández, J. et al. Inflammatory biomarkers in type 2 diabetic patients: effect of glycemic control and impact of ldl subfraction phenotype. Cardiovasc Diabetol 13, 34 (2014). https://doi.org/10.1186/1475-2840-13-34

Wang X, Bao W, Liu J, Ouyang YY, Wang D, Rong S, Xiao X, Shan ZL, Zhang Y, Yao P, Liu LG. Inflammatory markers and risk of type 2 diabetes: a systematic review and meta-analysis. Diabetes Care. 2013 Jan;36(1):166-75. doi: 10.2337/dc12-0702. PMID: 23264288; PMCID: PMC3526249.

Yu H, Rifai N. High sensitivity C reactive protein and atherosclerosis: From theory to therapy. Clin Biochem 2000;33:601 10

Zhu C, Yang H, Geng Q, Ma Q, Long Y, Zhou C, et al. Association of oxidative stress biomarkers with gestational diabetes mellitus in pregnant women: A case control study. PLoS One 2015;10:e0126490.

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Published

2025-05-14

How to Cite

1.
Merina A S, N K, Thankam V. S R, Varghese A, Kumar T S, Raman K T. Comparative Study on Crp An Inflammatory Biomarkers in Type 2 Diabetes Mellitus. J Neonatal Surg [Internet]. 2025May14 [cited 2025Sep.13];14(18S):1116-24. Available from: https://www.jneonatalsurg.com/index.php/jns/article/view/5837

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