Evaluating The Efficacy And Safety Of Oxycodone And Hydrocodone In Chronic Pain Management With Post Operative Surgical Patient
Keywords:
Oxycodone, hydrocodone, post-operative pain, opioid efficacy, adverse effectsAbstract
Chronic post-operative pain is a debilitating condition affecting 10–50% of surgical patients, with opioids like oxycodone and hydrocodone being primary therapeutic options. This study compared the efficacy, safety, and tolerability of these drugs in 80 post-operative patients (mean age: 52.4 years) over six months. Oxycodone demonstrated superior pain reduction (Day 30 VAS scores: mean rank 33.21 vs. 48.55 for hydrocodone, *p* < 0.001) and fewer adverse drug reactions (ADRs) (36.3% reported no ADRs vs. 9% for hydrocodone). Hydrocodone was associated with higher constipation rates (20% vs. 2.4%). Rescue medications were required by 76.3% of participants, and prolonged use correlated with dependence risk (ρ = 0.658, *p* < 0.001). The findings advocate for personalized opioid selection and multimodal pain management strategies
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