Serum Lipid Profile in Early Second Trimester as A Predictor of Pregnancy Induced Hypertension

Authors

  • Hepzibah Harriet Abigail
  • B. Jeyamani
  • Arun. G. Christopher

Keywords:

Pregnancy-induced hypertension, lipid profile, triglycerides, total cholesterol, diagnostic accuracy

Abstract

Background:
Pregnancy-induced hypertension (PIH) is a significant cause of maternal and fetal morbidity and mortality. Identifying early predictors of PIH can improve management and outcomes. This study investigates the role of serum lipid profiles in the early second trimester as predictors of PIH.

Objectives:
To assess whether serum lipid profile abnormalities in the early second trimester can predict the development of pregnancy-induced hypertension.

Methods:
This was a prospective observational study conducted at Vinayaka Missions Medical College and Hospital Salem, from May 2023 to October 2024. A total of 160 pregnant women between 14-20 weeks of gestation were enrolled. Participants’ lipid profiles (total cholesterol, triglycerides, HDL, LDL, and VLDL) were measured, and blood pressure was monitored throughout pregnancy to identify cases of PIH. Descriptive and inferential statistics were used for data analysis.

Results:
The study found that 16.3% of participants developed gestational hypertension (GHTN). Higher levels of total cholesterol (244.61 mg/dL), LDL (131.05 mg/dL), triglycerides (321.26 mg/dL), and VLDL (73.85 mg/dL) were significantly associated with the development of GHTN. The diagnostic accuracy of lipid profiling was high, with a sensitivity of 88.46%, specificity of 94.78%, and an AUC of 0.916.

Conclusions:
The findings suggest that serum lipid profiles, particularly total cholesterol, LDL, triglycerides, and VLDL, are valuable predictors for the development of PIH. Early lipid screening may help identify high-risk pregnancies, enabling timely intervention and better management

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References

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Published

2025-05-15

How to Cite

1.
Abigail HH, B. Jeyamani BJ, Christopher AG. Serum Lipid Profile in Early Second Trimester as A Predictor of Pregnancy Induced Hypertension. J Neonatal Surg [Internet]. 2025May15 [cited 2025Sep.21];14(24S):170-9. Available from: https://www.jneonatalsurg.com/index.php/jns/article/view/5909

Issue

Vol. 14 No. 24S (2025): Journal of Neonatal Surgery

Section

Original Article

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