Impact of Maternal Diabetes and Hypertension on Postoperative Outcomes in Neonates Undergoing Major Abdominal Surgery: A Retrospective Study

Authors

  • Mallikarjuna Reddy E
  • Suresh Kanna Subramaniam
  • Akita Akita
  • Arvindraj R Arvindraj R

Keywords:

Neonatal surgery, maternal diabetes, hypertension, postoperative complications, congenital anomalies

Abstract

Objective: This study aimed to assess the impact of maternal Type 2 Diabetes Mellitus (T2DM) and Hypertensive Disorders of Pregnancy (HDP) on postoperative outcomes in neonates undergoing major abdominal surgery.

Methods: We conducted a retrospective cohort study of neonates who underwent abdominal surgery for congenital gastrointestinal anomalies between January 2020 and December 2024 at a tertiary care center. Maternal medical history, neonatal demographics, surgical interventions, and postoperative outcomes were analyzed. The primary outcome was the incidence of postoperative complications within 30 days. Secondary outcomes included sepsis, duration of mechanical ventilation, length of hospital stay, and mortality. Statistical significance was set at p<0.05.

Results: Out of 204 neonates included, 62 (30.4%) were born to mothers with T2DM and/or HDP. These neonates had a higher incidence of postoperative sepsis (45.2% vs. 26.8%, p=0.008), prolonged mechanical ventilation (>5 days) (38.7% vs. 22.3%, p=0.015), and hospital stay >15 days (56.5% vs. 35.7%, p=0.012). Multivariate logistic regression revealed maternal T2DM (aOR 2.25, 95% CI: 1.18–4.29) and HDP (aOR 1.89, 95% CI: 1.05–3.39) as independent predictors of adverse postoperative outcomes.

Conclusion: Maternal diabetes and hypertension significantly increase the risk of postoperative complications in neonates undergoing abdominal surgery. Early identification and optimized management of maternal comorbidities may improve surgical outcomes.

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References

Nasr A, Langer JC. Neonatal surgical outcomes: what matters. Semin Pediatr Surg. 2014;23(5):270–274.

Deshmukh M, Patole S. Maternal diabetes and neonatal outcomes: A systematic review. Acta Paediatr. 2018;107(5):961–969.

Sibai BM. Hypertension in pregnancy: impact on neonatal outcome. Clin Perinatol. 2012;39(3):649–657.

Blumer JL, Reed MD. Neonatal pharmacology and surgery. Clin Pharmacokinet. 1999;37(6):451–473.

Tita AT, Landon MB, Spong CY, et al. Timing of delivery and neonatal outcomes in pregnancies with maternal disorders. N Engl J Med. 2009;360(19):1985–1993.

Kamana KC, Shakya S, Zhang H. Gestational diabetes mellitus and macrosomia: a literature review. Ann Nutr Metab. 2015;66(Suppl 2):14–20.

Metzger BE, Lowe LP, Dyer AR, et al. Hyperglycemia and adverse pregnancy outcomes. N Engl J Med. 2008;358(19):1991–2002.

Reddy UM, Ko CW, Willinger M. Maternal age and the risk of stillbirth throughout pregnancy in the United States. Am J Obstet Gynecol. 2006;195(3):764–770.

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Published

2025-05-16

How to Cite

1.
Reddy E M, Subramaniam SK, Akita A, Arvindraj R AR. Impact of Maternal Diabetes and Hypertension on Postoperative Outcomes in Neonates Undergoing Major Abdominal Surgery: A Retrospective Study. J Neonatal Surg [Internet]. 2025May16 [cited 2025Oct.23];14(7):580-2. Available from: https://www.jneonatalsurg.com/index.php/jns/article/view/5948

Issue

Vol. 14 No. 7 (2025): Journal of Neonatal Surgery

Section

Original Article

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