Formulation and Evaluation of Pharmaceutical Filament for 3D Printing Containing Lamotrigine

Authors

  • Pallavi Joshi
  • Ashutosh Badola

Keywords:

3D Printing, Lamotrigine, Pharmaceutical Filament, Drug Delivery, Personalized Medicine, Hot melt extrusion

Abstract

This research explores the development and evaluation of a novel 3D printed oral drug delivery system for Lamotrigine using hot melt extrusion (HME) and fused deposition modeling (FDM) techniques. Polyvinyl alcohol (PVA) served as the polymeric carrier due to its biocompatibility and excellent printability, while triethyl citrate (TEC) was employed as a plasticizer to improve filament flexibility and processability. The Wellzoom hot melt extruder was utilized to manufacture drug-loaded filaments, which could be then printed into dosage forms using FDM. A comprehensive analysis, including thermal, mechanical, morphological, and other studies, was conducted to evaluate the performance and stability of the filament. The results demonstrated the potential for 3D printed Lamotrigine filament which highlighted the utility of this method for personalized medicine.

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

References

Alhnan, M. A., Okwuosa, T. C., Sadia, M., Wan, K.-W., Ahmed, W., & Arafat, B. (2016). Emergence of 3D printed dosage forms: Opportunities and challenges. Advanced Drug Delivery Reviews, 108, 111–135. https://doi.org/10.1016/j.addr.2016.04.002

Goyanes, A., Buanz, A. B., Basit, A. W., & Gaisford, S. (2014). Fused-filament 3D printing (3DP) for fabrication of tablets. International Journal of Pharmaceutics, 476(1–2), 88–92. https://doi.org/10.1016/j.ijpharm.2014.09.044

Khaled, S. A., Burley, J. C., Alexander, M. R., Yang, J., & Roberts, C. J. (2014). 3D printing of five-in-one dose combination polypill with defined immediate and sustained release profiles. Journal of Controlled Release, 217, 308–314. https://doi.org/10.1016/j.jconrel.2015.09.031

Melocchi, A., Uboldi, M., Maroni, A., Foppoli, A., Palugan, L., Zema, L., & Gazzaniga, A. (2020). 3D printing by fused deposition modeling of a multi-compartmental dosage form for oral administration. Journal of Drug Delivery Science and Technology, 57, 101704. https://doi.org/10.1016/j.jddst.2020.101704

Zhang, J., Feng, X., Patil, H., Tiwari, R. V., & Repka, M. A. (2017). Pharmaceutical additive manufacturing: A novel tool for complex and personalized drug delivery systems. AAPS PharmSciTech, 18(1), 30–39. https://doi.org/10.1208/s12249-016-0700-5

Prasad, L. K., & Smyth, H. (2016). 3D Printing technologies for drug delivery: A review. Drug Development and Industrial Pharmacy, 42(7), 1019–1031. https://doi.org/10.3109/03639045.2015.1120743

Sadia, M., Arafat, B., Ahmed, W., Forbes, R. T., Alhnan, M. A. (2016). Channelled tablets: An innovative approach to accelerating drug release from 3D printed tablets. Journal of Controlled Release, 269, 355–363. https://doi.org/10.1016/j.jconrel.2017.11.003

Palekar, S., Patki, M., Patel, K., Wagh, M., & Ranade, A. (2019). Hot-melt extrusion: A promising strategy to enhance solubility of poorly water-soluble drugs. Asian Journal of Pharmaceutical Sciences, 14(6), 669–683. https://doi.org/10.1016/j.ajps.2019.03.006

Jamróz, W., Kurek, M., Łyszczarz, E., Szafraniec-Szczęsny, J., & Jachowicz, R. (2020). 3D printing in pharmaceutical and medical applications – recent achievements and challenges. Pharmaceutical Research, 37, 176. https://doi.org/10.1007/s11095-020-02864-5

Arafat, B., et al. (2018). Hot-melt extrusion for pharmaceutical applications: A review. Journal of Pharmaceutical Investigation, 48(3), 229–241. https://doi.org/10.1007/s40005-017-0339-5

Mohammed, A. A., Ayyoubi, S., Raza, A., & Alanazi, F. K. (2020). Development and optimization of 3D printed oral tablets using fused deposition modeling. Pharmaceutical Development and Technology, 25(5), 583–593. https://doi.org/10.1080/10837450.2020.1739293

Wang, J., Goyanes, A., Gaisford, S., & Basit, A. W. (2016). Stereolithographic (SLA) 3D printing of oral modified-release dosage forms. International Journal of Pharmaceutics, 503(1–2), 207–212. https://doi.org/10.1016/j.ijpharm.2016.03.016

Xu, X., et al. (2020). Triethyl citrate as an efficient plasticizer for polyvinyl alcohol-based pharmaceutical films. International Journal of Pharmaceutics, 579, 119156. https://doi.org/10.1016/j.ijpharm.2020.119156

Wang, Y., Yu, Y., & Zhang, X. (2021). Development of PVA-based drug-loaded filaments for 3D printing using hot-melt extrusion. Journal of Drug Delivery Science and Technology, 61, 102085. https://doi.org/10.1016/j.jddst.2020.102085

Trenfield, S. J., et al. (2018). Precision medicine by 3D printing: Drug development and manufacture. International Journal of Pharmaceutics, 558, 328–341. https://doi.org/10.1016/j.ijpharm.2018.08.064

Korte, C., & Quodbach, J. (2018). 3D printing of drug-eluting implants: A pilot study. European Journal of Pharmaceutical Sciences, 111, 134–143. https://doi.org/10.1016/j.ejps.2017.10.026

Okwuosa, T. C., Stefaniak, D., Arafat, B., Isreb, A., Wan, K.-W., & Alhnan, M. A. (2016). Fabricating a patient-specific immediate release tablet via 3D printing. International Journal of Pharmaceutics, 494(2), 568–577. https://doi.org/10.1016/j.ijpharm.2015.03.042

Seoane-Viaño, I., Fuenmayor, E., & Goyanes, A. (2021). Direct powder extrusion 3D printing of medicines: Current developments and future prospects. International Journal of Pharmaceutics, 599, 120455. https://doi.org/10.1016/j.ijpharm.2021.120455

Martinez, P. R., et al. (2018). Pharmaceutical applications of 3D printing. Biotechnology Advances, 36(4), 982–991. https://doi.org/10.1016/j.biotechadv.2017.12.011

Tagami, T., & Ozeki, T. (2017). 3D printing of tablet formulations prepared using a semi-solid extrusion system. Pharmaceuticals, 10(3), 26. https://doi.org/10.3390/ph10030026.

.

Downloads

Published

2025-05-20

How to Cite

1.
Joshi P, Badola A. Formulation and Evaluation of Pharmaceutical Filament for 3D Printing Containing Lamotrigine. J Neonatal Surg [Internet]. 2025May20 [cited 2025Sep.25];14(25S):794-9. Available from: https://www.jneonatalsurg.com/index.php/jns/article/view/6181

Issue

Vol. 14 No. 25S (2025): Journal of Neonatal Surgery

Section

Original Article

License

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

You are free to:

  • Adapt — remix, transform, and build upon the material for any purpose, even commercially.

Terms:

  • Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
  • No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.