Formulation and Evaluation Of A Gastroretentive Drug Delivery System (Floating Tablets) For Propafenone Hydrochloride
Keywords:
Gastroretentive drug delivery, Propafenone Hydrochloride, Floating tablets, HPMC K4M, Sustained releaseAbstract
This study presents the formulation and evaluation of a gastroretentive drug delivery system (GRDDS) in the form of floating tablets for Propafenone Hydrochloride, a Class I antiarrhythmic drug with a narrow absorption window and extensive first-pass metabolism. The floating tablets were prepared using the wet granulation method with hydroxypropyl methylcellulose (HPMC K4M), Carbopol 934P, sodium bicarbonate, and citric acid to provide buoyancy and sustained release. Five formulations (F1–F5) were developed with varying HPMC concentrations. Evaluation parameters included hardness, friability, floating lag time, total floating time, and in vitro drug release. Formulation F5, containing the highest HPMC concentration, demonstrated optimal properties with prolonged floating (>12 hours), sustained drug release (98.5% over 12 hours), and acceptable mechanical strength. These results confirm that the optimized formulation can effectively prolong gastric residence and improve the bioavailability of Propafenone Hydrochloride, offering a promising approach for managing arrhythmias requiring controlled drug delivery.
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