Effect of Hybrid Mode Rehabilitation on Aerobic Endurance and quality of Life: Evaluation Using 6MWT, VO2 Max, and PAH-SYMPACT Questionnaire in Stage 3 COPD Patients With Pulmonary Hypertension
Keywords:
COPD, Pulmonary hypertension, 6MWT, PAH-SYMPACT, Hybrid rehabilitationAbstract
Introduction: Pulmonary hypertension (PH) is a frequent and serious complication in patients with chronic obstructive pulmonary disease (COPD), particularly in group 3 PH, where hypoxia and lung disease contribute to vascular remodelling and increased pulmonary arterial pressures. COPD-PH is associated with increased morbidity, reduced exercise capacity, and higher mortality rates. Despite the clinical burden, optimal management remains a challenge. Pulmonary rehabilitation has emerged as a promising intervention to improve exercise tolerance and quality of life in this population.
Methodology: A prospective, randomized controlled, single-blinded trial was conducted to compare the effects of a hybrid rehabilitation protocol (combination of aerobic, resistance, and breathing exercises) with conventional physiotherapy in patients with stage 3 COPD with PH. A total of 40 participants were randomized into two equal groups. Functional capacity was assessed using the 6-minute walk test (6MWT) and VO2 max. Quality of life was evaluated using the one day version of PAH-SYMPACT questionnaires. Statistical analysis included paired and unpaired t-tests and chi-square tests to assess within-group and between-group differences.
Results: Patients in the experimental group showed significant improvement in 6MWT distance (mean increase of 52.3 ± 10.6 meters, p < 0.001) and VO2 max (p < 0.01) compared to the control group. Quality of life scores, as measured by PAH-SYMPACT, also demonstrated statistically significant improvements in the experimental group (p < 0.05). The control group showed minimal changes in all outcome measures.
Conclusion: The hybrid rehabilitation protocol significantly improved functional capacity and quality of life in COPD patients with pulmonary hypertension compared to conventional physiotherapy. These findings highlight the role of comprehensive pulmonary rehabilitation in managing COPD-PH and suggest its potential to mitigate morbidity and enhance clinical outcomes in this high-risk population.
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