Nanostructured Lipid Carriers As A Drug Delivery System
DOI:
https://doi.org/10.63682/jns.v14i7.6456Keywords:
Drug, Nanostructured Lipid Carriers (Nlc), Thermodurmal, Nanotechnology, NateglinideAbstract
Nanostructured Lipid Carriers (Nlcs) Are Drug Delivery System Comprising A Mixture Of Solid And Liquid Lipids As A Core Matrix. Furthermore, Nlcs Are Second-Generation Lipid Nanoparticles That Have An Unstructured Matrix With High Drug Loading Capacity, Which Are Suitable For Drug Delivery System. Due To These Unique Characteristics, Several Studies Have Investigated Nlcs As Alternate Carriers For The Dermal Delivery Of Pharmaceuticals, Particularly Natural Active Ingredients. Among The Associated Benefits Discovered Include Biocompatible Ingredients, Drug Release Modification, And Adhesion To The Skin, Film-Forming Ability With Hydration Of The Superficial Skin Layers, As Well As Increased Penetration And Permeation Into Deeper Skin Layers. Nlc It Can Be Easily Used As A Carrier For Drugs Via Different Routes Of Administration Such As Oral, Parenteral, Ocular, And Nasal. Nanostructured Lipid Carriers (Nlcs) Have Been Reported To Be An Alternative System And Are Considered Superior To Many Other Traditional Lipid-Based Nanocarriers Such As Emulsions, Nanoemulsion, Liposome, Microparticle, And Solid Lipid Nanoparticle (Slns). It Imparts Many Advantages Over Sln’s Such As Increased Solubility And Stability, Improved Permeability And Bioavailability, Enhanced Drug Loading Capacity, Drug Release Modulation Flexibility, Reduced Adverse Effects, Prolonged Half-Life, And Tissue-Targeted Delivery. This Review Highlights The Nlc With A Focus On The Structure ,Pharmaceutical And Therapeutic Applications Towards Targeted Drug Delivery Of Nlc In Delivery Systems
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