Indonesian Elderly With Psoriatic Arthritis And Scleroderma: A Case Report
Abstract
Introduction: Psoriatic arthritis and scleroderma co-occurring was an uncommon case.
Case presentation: An Indonesian woman, 70 years old, complained of pain and stiffness in the right knee and ankle joints. This pain and stiffness reduce as the patient moves or stretches. Meanwhile, she has a history of type 2 diabetes mellitus (T2DM) and has been taking Sitagliptin 100 mg once daily for 10 years. In physical examination, she presented an abnormality in the right knee and ankle joint, with deformity and stiffness in several joints. Additional examination showed that the classification criteria for psoriatic arthritis (CASPAR) score was 3, the disease activity for psoriatic arthritis (DAPSA) score was 20 (moderate), and the modified Rodnan skin score (mRss) was 20 (severe). Then, she has a random blood glucose of 166 mg/dL, GD2PP 209 mg/dL, and HbA1c 8.3%. The immunoserology revealed a solid positive for antigen Scl-70, indicating positive autoantibody in systemic scleroderma. The patient received Myfortic 2×360 mg/day, Methylprednisolone 4 mg once daily, Folic acid 1 mg once daily, Nifedipine 5 mg thrice daily, Sitagliptin 100 mg once daily, and Natrium diclofenac 50 mg twice daily (for pain appearance). She was followed for 6 months and showed improvement after undergoing treatment.
Conclusion: The prognosis of psoriatic arthritis is influenced by early diagnosis, the number of affected joints, and bone inflammation. Meanwhile, the prognosis of scleroderma depends on the symptoms that appear. Therefore, both psoriatic arthritis and scleroderma require comprehensive management, including early diagnosis and treatment of complications to improve quality of life.
Downloads
Metrics
References
Yuliasih Y, Handoyo M, Rahmawati LD, Wibisono S, Nisa N. Correlation Between Insulin Resistance and Psoriatic Arthritis Disease Activity: A Cross-Sectional Study. Journal of psoriasis and psoriatic arthritis. 2023;8(4):129-33. doi: 10.1177/24755303231180508.
Gossec L, Kerschbaumer A, Ferreira RJO, Aletaha D, Baraliakos X, Bertheussen H, et al. EULAR recommendations for the management of psoriatic arthritis with pharmacological therapies: 2023 update. Annals of the rheumatic diseases. 2024;83(6):706-19. doi: 10.1136/ard-2024-225531.
Lembke S, Macfarlane GJ, Jones GT. The worldwide prevalence of psoriatic arthritis-a systematic review and meta-analysis. Rheumatology (Oxford, England). 2024. doi: 10.1093/rheumatology/keae198.
Tobing M, Darmadi S, Yuliasih Y. Limited systemic sclerosis in a young boy. Indonesian Journal of Clinical Pathology and Medical Laboratory. 2006;13(1):31-3.
Bairkdar M, Rossides M, Westerlind H, Hesselstrand R, Arkema EV, Holmqvist M. Incidence and prevalence of systemic sclerosis globally: a comprehensive systematic review and meta-analysis. Rheumatology (Oxford, England). 2021;60(7):3121-33. doi: 10.1093/rheumatology/keab190.
Pinto AS, Santos FC, Dinis SP, Madeira N, Ferreira JF, Vaz C. Systemic sclerosis and rheumatoid arthritis overlap syndrome - management of severe cardiac, pulmonary and articular involvement. Reumatologia. 2023;61(1):55-62. doi: 10.5114/reum/161299.
Mehra S, Walker J, Patterson K, Fritzler MJ. Autoantibodies in systemic sclerosis. Autoimmunity reviews. 2013;12(3):340-54. doi: 10.1016/j.autrev.2012.05.011.
Pope JE, Denton CP, Johnson SR, Fernandez-Codina A, Hudson M, Nevskaya T. State-of-the-art evidence in the treatment of systemic sclerosis. Nature reviews Rheumatology. 2023;19(4):212-26. doi: 10.1038/s41584-023-00909-5.
Patterson KA, Roberts-Thomson PJ, Lester S, Tan JA, Hakendorf P, Rischmueller M, et al. Interpretation of an Extended Autoantibody Profile in a Well-Characterized Australian Systemic Sclerosis (Scleroderma) Cohort Using Principal Components Analysis. Arthritis & rheumatology (Hoboken, NJ). 2015;67(12):3234-44. doi: 10.1002/art.39316.
Brady SM, Shapiro L, Mousa SA. Current and future direction in the management of scleroderma. Archives of dermatological research. 2016;308(7):461-71. doi: 10.1007/s00403-016-1647-6.
Yamaoka T, Inoue T, Kitaba S, Yokomi A, Azukizawa H, Terao M, et al. Psoriatic Arthritis Complicating Systemic Sclerosis: Possible Involvement of M2 Macrophages. Annals of dermatology. 2015;27(5):631-2. doi: 10.5021/ad.2015.27.5.631.
McLaughlin M, Ostör A. Early treatment of psoriatic arthritis improves prognosis. The Practitioner. 2014;258(1777):21-4, 3.
Yunita I, Anggraeni S. Secukinumab Therapy in Psoriasis Management. Berkala Ilmu Kesehatan Kulit dan Kelamin. 2022;34(1):59-65. doi: 10.20473/bikk.V34.1.2022.59-65.
Gunawan H, Awalia A, Soeroso J. The Coexistence of Systemic Lupus Erythematosus and Psoriasis: Is It Possible? Acta medica Indonesiana. 2018;50(2):144-50.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Anugrah Perdana Masloman, Lita Diah Rahmawati

This work is licensed under a Creative Commons Attribution 4.0 International License.
You are free to:
- Share — copy and redistribute the material in any medium or format
- Adapt — remix, transform, and build upon the material for any purpose, even commercially.
Terms:
- Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.