A Review on Biomatrix Tablets with Natural Polymers
Keywords:
Controlled release, Matrix tablets, Agar, Sodium Alginate, Biopolymer, Natural PolymerAbstract
The creation of controlled release systems enables drugs to be delivered at a specific and expected rate in a programmed manner, thereby regulating the optimal concentration and ensuring a consistent concentration at a particular site or receptor. Matrix tablets represent a widely used type of controlled release drug delivery system, which releases medication through mechanisms of diffusion or dissolution control. The active ingredients are evenly integrated within the material that regulates the release rate, for example, polymers can be hydrophilic, plastic, lipid-based, or composed of minerals, among others. Polymer can be either man-made or naturally-derived, but the appeal of natural polymers in pharmaceutical uses lies in their cost-effectiveness, accessibility, and non-toxic nature. Chitosan, alginate, starch, and collagen are examples of naturally occurring polymers that are used in tissue engineering matrix, regenerative pharmaceuticals, detergents, adhesives, packaging, biodegradable plastics, textiles, and rubber. Because they are relatively safe, biocompatible, and readily metabolized by the body's enzymes. Biopolymers are the organic materials derived from natural sources. Because the biopolymers are biocompatible and biodegradable, they have various uses, including in the food industry. for edible films and emulsions, as well as in the pharmaceutical industry for tissue scaffolds, wound healing, dressing materials, drug transport materials, and medical implants such as organs. Since natural polymers are essentially polysaccharides, they have no negative effects and are biocompatible. The advantages of natural polymers over synthetic ones, as well as their use in creating innovative drug delivery systems, are covered in this paper.
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