Biomarkers In Orthodontic Tooth Movement
Keywords:
Biomarkers, orthodontic tooth movement, bone remodeling, gingival crevicular fluidAbstract
Orthodontic tooth movement is a complex process of various mechanisms bringing about remodeling changes in periodontium, alveolar bone and gingiva. This process occurs as a response to the mechanical forces applied onto the teeth by orthodontic appliances which gets transmitted to the alveolar bone, periodontal ligament and gingival tissue. These tissues undergo adaptive changes and result in movement of the teeth to their desired positions. The exact mechanisms of the changes occurring at cellular level is of great interest and importance in modern orthodontic practice. The orthodontists can better understand the mechanisms of action and the significance of various biomarkers to have clear insight into the phases of tooth movement, site and nature of force applied and its impact on the alveolar tissues, the response of the tissues to forces applied on the teeth and the continuous process of bone remodeling even after cessation of active orthodontic tooth movement. the gingival crevicular fluid (GCF) is a medium of study of these processes as it contains concentrations of biomarkers that reflect the underlying process of tissue adaptation. GCF can be collected from patients using filter paper strips, gingival washings, platinum loops and micropipettes. Analyzing the GCF can reveal its composition and the various biomarkers present in it. The orthodontist can use this to understand the intricate details of bone remodeling and make proper choice of mechanical force application to shorten orthodontic treatment time and avoid adverse effects of improper force application
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Kumar AA, Saravanan K, Kohila K, Kumar SS. Biomarkers in orthodontic tooth movement. J Pharm Bioallied Sci. 2015
Krishnan V, Davidovitch Z. Cellular, molecular, and tissue level reactions to orthodontic force. Am J Orthod Dentofacial Orthop 2006;129:469
Smith RJ, Burstone CJ. Mechanics of tooth movement. Am J Orthod. 1984 Apr;85(4):294-307
Asiry M, Biological aspects of orthodontic tooth movement: A review of literature. Saudi Journal of Biological Sciences, 2018
Dudic A, Kiliaridis S, Mombelli A, Giannopoulou C. Composition changes in gingival crevicular fluid during orthodontic tooth movement: Comparisons between tension and compression sides. Eur J Oral Sci 2006;114:416 22
Yamasaki K, Miura F, Suda T. Prostaglandin as a mediator of bone resorption induced by experimental tooth movement in rats. J Dent Res. 1980 Oct;59(10):1635-42.
Alansari S, Sangsuwon C, Vongthongleur T, Kwal R, chneh Teo M, Lee YB, Nervina J, Teixeira C, Alikhani M. Biological principles behind accelerated tooth movement. In Seminars in Orthodontics 2015 Sep 1 (Vol. 21, No. 3, pp. 151-161).
Kanzaki H, Chiba M, Takahashi I, Haruyama N, Nishimura M, Mitani H. Local OPG gene transfer to periodontal tissue inhibits orthodontic tooth movement. J Dent Res 2004;83:920 5
Davidovitch Z, Nicolay OF, Ngan PW, Shanfeld JL. Neurotransmitters, cytokines, and the control of alveolar bone remodeling in orthodontics. Dent Clin North Am 1988;32:411 35.
Saito S, Ngan P, Saito M, Kim K, Lanese R, Shanfeld J, et al. Effects of cytokines on prostaglandin E and cAMP levels in human periodontal ligament fibroblasts in vitro. Arch Oral Biol 1990;35:387 95.
Alhashimi N, Frithiof L, Brudvik P, Bakhiet M. Orthodontic tooth movement and de novo synthesis of proinflammatory cytokines. Am J Orthod Dentofacial Orthop 2001;119:307 12.
Alhashimi N, Frithiof L, Brudvik P, Bakhiet M. Orthodontic movement induces high numbers of cells expressing IFN gamma at mRNA and protein levels. J Interferon Cytokine Res 2000;20:7 12.
Başaran G, Ozer T, Kaya FA, Kaplan A, Hamamci O. Interleukine-1beta and tumor necrosis factor-alpha levels in the human gingival sulcus during orthodontic treatment. Angle Orthod. 2006
Barcelos LS, Talvani A, Teixeira AS, Vieira LQ, Cassali GD, Andrade SP, et al. (2005). Impaired inflammatory angiogenesis, but not leukocyte influx, in mice lacking TNFR1. J Leukoc Biol 78:352-358.
Garlet GP, Cardoso CR, Campanelli AP, Ferreira BR, Avila-Campos MJ, Cunha FQ, et al. (2007). The dual role of p55 tumour necrosis factor-alpha receptor in Actinobacillus actinomycetemcomitans-induced experimental periodontitis: host protection and tissue destruction. Clin Exp Immunol 147:128-138.
Hu YJ, Liu WT, Wang YL, He H. [Effects of recombinant human growth hormone on local expression of insulin-like growth factor- during orthodontic tooth movement]. Zhonghua Kou Qiang Yi Xue Za Zhi. 2016;51(6):374-8.
Sabatini M, Boyce B, Aufdemorte T, Bonewald L, Mundy GR. Infusions of recombinant human interleukins 1 alpha and 1 beta cause hypercalcemia in normal mice. Proc Natl Acad Sci U S A 1988;85:5235 9
Almotareb FL, Al-Shameri BHH, Al-Najhi MMA, Al-dossary OAI, Al-Shamahy HA. (2023) Increase of Transforming Growth Factor-Beta 1 in Gingival Crevicular Fluid during Human Orthodontic Tooth Movement. J Oral Med and Dent Res. 4(2):1-09.
Mort JS, Buttle DJ. Cathepsin B. Int J Biochem Cell Biol. 1997 29(5):715-20.
Seung-Hoon Rhee, Junghee Kang, Dong-Seok Nahm, Cystatins and cathepsin B during orthodontic tooth movement, American Journal of Orthodontics and Dentofacial Orthopedics, Volume 135, Issue 1, 2009,
Yamaguchi M, Shimizu N, Shibata Y, Abiko Y. Effects of different magnitudes of tension-force on alkaline phosphatase activity in periodontalligament cells. J Dent Res. 1996; 75: 889–894.
Burstone MS. Histochemical demonstration of acid phosphatase activity in osteoclasts. J Histochem Cytochem. 1959; 7: 39–41.
Farahani M, Safavi SM, Dianat O, Khoramian Tusi S, Younessian F. Acid and Alkaline Phosphatase Levels in GCF during Orthodontic Tooth Movement. J Dent (Shiraz). 2015 Sep;16(3 Suppl):237-45.
Cantarella G, Cantarella R, Caltabiano M, Risuglia N, Bernardini R, Leonardi R. Levels of matrix metalloproteinases 1 and 2 in human gingival crevicular fluid during initial tooth movement. Am J Orthod Dentofacial Orthop 2006;130:568
Redlich M, Reichenberg E, Harari D, Zaks B, Shoshan S, Palmon A. The Effect of Mechanical Force on mRNA Levels of Collagenase, Collagen Type I, and Tissue Inhibitors of Metalloproteinases in Gingivae of Dogs. J Dent Res. 2001;80(12):2080–4.
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