Evaluation of Wound Healing Activity of an Ethanolic extract of Anogeissus Latifolia leaves in Albino rats.
DOI:
https://doi.org/10.63682/jns.v14i29S.6745Keywords:
wound healing, anogeissus latifolia, povidone oinment, excision wound modelAbstract
Background: The skin has been described as the largest organ in the body. Wound, a break in the continuity of any bodily tissue due to violence, where violence is understood to encompass any action of external agency, including, for example, surgery. An injury to the body (as from violence, accident, or surgery) that typically involves laceration or breaking of a membrane (such as the skin) and usually damage to underlying tissues.
The Healing is a complex process of restoration of cell structure and layers of tissue, which may occur in two ways:
- a) Regeneration – It is the means of renewal of the extinct tissue by a like tissue.
- b) Repair – It’s the process of replacing the lost tissue by granulation tissue.
This granulation tissue fully develops to form the scar tissue.
Objective : The purpose of this study was to determine the effect of wound healing activity of herbal plant Selection Collection and Authentication of Plant Material. Extraction of plant material with Ethanol Preliminary Phytochemical analysis Evaluation of wound healing activity of Anogeissus Latifolia leaves in albino rats Histopathological analysis Statistical analysis.
Methods:This experimental study examined 12 animals each group containing 4 randomly divided into treatment anagoiessus latifolia ethanolic extract of oinment and control group wound healing activity was measured by using control and standard group .
Result: Extract treated excision wounds showed an increased rate of wound contraction, leading to faster healing as confirmed by the increased healed area when compared to the control untreated group. The ALLE was recorded similar effectiveness when compared to the group treated with a commercial brand of 5% povidone iodine ointment in but the magnitude was lesser than standard.
Conclusion: The study thus demonstrated the wound healing activity of ethanloic leaf extract of .Anogeissus latifolia,and found to be effective in the functional recovery of the wound. The result may be attributed to the phytoconstituents such as flavonoids and phenolics present in it which may be due to their individual or cumulative effect that enhanced wound healing and provided scientific evidence to the ethnomedicinal futures of Anogeissus latifolia.
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