A Comprehensive Review On Recent Advancements In Nanosponges: Innovations, Biomedical Applications, And Future Perspectives
Keywords:
Nanosponges, Drug Delivery, Cyclodextrin-Based Nanocarriers, Biomedical Applications and Controlled ReleaseAbstract
Nanosponges represent advanced nanostructures which boost drug dissolution properties and enhance preservation as well as distribution efficiency while controlling drug release patterns. The most researched nanosponge type known as cyclodextrin-based nanosponges provides targeted drug delivery through inclusion and non-inclusion complex approaches. Drug encapsulation and release efficiency improved through recent developments in synthetic methods which include microwave-assisted, ultrasound-assisted and hyper-crosslinking techniques. Drugs bound to nanosponges through carbon nanotube, silver nanowire and titanium dioxide integration improve the uptake rates and therapeutic effectiveness. These materials have proven useful in medical treatments of cancer alongside gene inhibition technologies and serving as protein carriers and environmental pollution treatment systems. Widespread clinical application remains limited because of nanotoxicity problems and technical scalability issues together with regulatory barriers. New studies will combine diagnosis elements with therapeutic capabilities while studying improved polymer-to-crosslinker stoichiometry for future economical environmentally-friendly synthesis methods. This review presents an extensive analysis of new nanosponge developments and their biomedical applications together with projections for future advancement as an effective nanomaterial in drug delivery systems and nanomedical practice.
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Swaminathan S, Vavia PR, Trotta F, Cavalli R, Tumbiolo S, Bertinetti L, et al. Structural evidence of differential forms of nanosponges of beta-cyclodextrin and its effect on solubilization of a model drug. J Inclusion Phenom Macrocycl Chem. 2013;76(1):201–11.
Ahire PS, Bhambere DS, Patil MP, Kshirsagar SJ. Recent advances in nanosponges as a drug delivery system. Indian J Drugs. 2020;8(1):8–17.
Swaminathan S, Cavalli R, Trotta F, Ferruti P, Ranucci E, Gerges I, et al. In vitro release modulation and conformational stabilization of a model protein using swellable polyamidoamine nanosponges of β-cyclodextrin. J Inclusion Phenom Macrocycl Chem. 2010;68(1):183–91.
Patel EK, Oswal R. Nanosponge and microsponges: a novel drug delivery system. IJRPC. 2012;2:237–44.
Swaminathan S, Pastero L, Serpe L, Trotta F, Vavia P, Aquilano D, et al. Cyclodextrin-based nanosponges encapsulating camptothecin: physicochemical characterization, stability and cytotoxicity. Eur J Pharm Biopharm. 2010;74(2):193–201.
Shinde G, Kesarla R, Bhatt D, Bangale G, Umalkar D, Virag G. Current status of colloidal system (nano range). Int J Drug Formul Res. 2011;2:39–54.
Joseph X, Akhil V, Arathi A, Mohanan PV. Nanobiomaterials in support of drug delivery related issues. Mater Sci Eng B. 2022;279:115680.
Sajjadi M, Nasrollahzadeh M, Jaleh B, Jamalipour Soufi G, Iravani S. Carbon-based nanomaterials for targeted cancer nanotherapy: Recent trends and future prospects. J Drug Target. 2021;29:716–41.
Carrion CC, Nasrollahzadeh M, Sajjadi M, Jaleh B, Jamalipour Soufi G, Iravani S. Lignin, lipid, protein, hyaluronic acid, starch, cellulose, gum, pectin, alginate and chitosan-based nanomaterials for cancer nanotherapy: Challenges and opportunities. Int J Biol Macromol. 2021;178:193–228.
Iravani S, Varma RS. Plant pollen grains: A move towards green drug and vaccine delivery systems. Nano-Micro Lett. 2021;13:128.
Iravani S, Varma RS. Important roles of oligo- and polysaccharides against SARS-CoV-2: Recent advances. Appl Sci. 2021;11:3512.
Iravani S, Varma RS. Nanosponges for water treatment: Progress and challenges. Appl Sci. 2022;12:4182.
Wang Y, Pisapati AV, Zhang XF, Cheng X. Recent developments in nanomaterial-based shear-sensitive drug delivery systems. Adv Healthc Mater. 2021;10:2002196.
Iravani S. Nano- and biosensors for the detection of SARS-CoV-2: Challenges and opportunities. Mater Adv. 2020;1:3092–103.
Iravani S. Nanophotocatalysts against viruses and antibiotic-resistant bacteria: Recent advances. Crit Rev Microbiol. 2022;48:67–82.
Osmani RAM, Hani U, Bhosale RR, Kulkarni PK, Shanmuganathan S. Nanosponge carriers-an archetype swing in cancer therapy: A comprehensive review. Curr Drug Targets. 2017;18:108–18.
Allahyari S, Zahednezhad F, Khatami M, Hashemzadeh N, Zakeri-Milani P, Trotta F. Cyclodextrin nanosponges as potential anticancer drug delivery systems to be introduced into the market, compared with liposomes. J Drug Deliv Sci Technol. 2022;67:102931.
Utzeri G, Matias PMC, Murtinho D, Valente AJM. Cyclodextrin-based nanosponges: Overview and opportunities. Front Chem. 2022;10:859406.
Szejtli J. Past, present, and future of cyclodextrin research. Pure Appl Chem. 2004;76:1825–45.
Lembo D, Cavalli R. Nanoparticulate delivery systems for antiviral drugs. Antivir Chem Chemother. 2010;21(2):53–70.
Prabhu PP, Prathvi, Gujaran TV, Mehta CH, Suresh A, Koteshwara KB, et al. Development of lapatinib nanosponges for enhancing bioavailability. J Drug Deliv Sci Technol. 2021;65:102684.
Lembo D, Trotta F, Cavalli R. Cyclodextrin-based nanosponges as vehicles for antiviral drugs: Challenges and perspectives. Nanomedicine. 2018;13:477–80.
Coviello V, Sartini S, Quattrini L, Baraldi C, Gamberini MC, La Motta C. Cyclodextrin-based nanosponges for the targeted delivery of the anti-restenotic agent DB103: A novel opportunity for the local therapy of vessels wall subjected to percutaneous intervention. Eur J Pharm Biopharm. 2017;117:276–85.
Sherje AP, Dravyakar BR, Kadam D, Jadhav M. Cyclodextrin-based nanosponges: A critical review. Carbohydr Polym. 2017;173:37–49.
Tiwari K, Bhattacharya S. The ascension of nanosponges as a drug delivery carrier: Preparation, characterization, and applications. J Mater Sci Mater Med. 2022;33:28.
Deng J, Chen QJ, Li W, Zuberi Z, Feng JX, Lin QL, et al. Toward improvements for carrying capacity of the cyclodextrin-based nanosponges: Recent progress from a material and drug delivery. J Mater Sci. 2021;56:5995–6015.
Wang H, Yapa AS, Kariyawasam NL, Shrestha TB, Kalubowilage M, Wendel SO, et al. Rationally designed peptide nanosponges for cell-based cancer therapy. Nanomedicine. 2017;13:2555–64.
Shailaja D, Pramodkumar S. Nanosponges encapsulated phytochemicals for targeting cancer: A review. Curr Drug Targets. 2021;22:443–62.
Varan C, Anceschi A, Sevli S, Bruni N, Giraudo L, Bilgiç E, et al. Preparation and characterization of cyclodextrin nanosponges for organic toxic molecule removal. Int J Pharm. 2020;585:119485.
Pawar S, Shende P. A comprehensive patent review on β-cyclodextrin cross-linked nanosponges for multiple applications. Recent Pat Nanotechnol. 2020;14:75–89.
Varma RS. Greener approach to nanomaterials and their sustainable applications. Curr Opin Chem Eng. 2012;1:123–8.
Varma RS. Journey on greener pathways: From the use of alternate energy inputs and benign reaction media to sustainable applications of nano-catalysts in synthesis and environmental remediation. Green Chem. 2014;16:2027–41.
Varma RS. Greener and sustainable chemistry. Appl Sci. 2014;4:493–7.
Varma RS. Greener and sustainable trends in synthesis of organics and nanomaterials. ACS Sustain Chem Eng. 2016;4:5866–78.
Varma RS. Biomass-derived renewable carbonaceous materials for sustainable chemical and environmental applications. ACS Sustain Chem Eng. 2019;7:6458–70.
Sharma K, Kadian V, Kumar A, Mahant S, Rao R. Evaluation of solubility, photostability and antioxidant activity of ellagic acid cyclodextrin nanosponges fabricated by melt method and microwave-assisted synthesis. J Food Sci Technol. 2021;59:898–908.
Ciesielska A, Ciesielski W, Girek B, Girek T, Koziel K, Kulawik D, et al. Biomedical application of cyclodextrin polymers cross-linked via dianhydrides of carboxylic acids. Appl Sci. 2020;10:8463.
Caldera F, Tannous M, Cavalli R, Zanetti M, Trotta F. Evolution of cyclodextrin nanosponges. Int J Pharm. 2017;531:470–9.
Jain A, Prajapati SK, Kumari A, Mody N, Bajpai M. Engineered nanosponges as versatile biodegradable carriers: An insight. J Drug Deliv Sci Technol. 2020;57:101643.
Kumari P, Singh P, Singhal A, Alka. Cyclodextrin-based nanostructured materials for sustainable water remediation applications. Environ Sci Pollut Res. 2020;27:32432–48.
Khazaei Monfared Y, Mahmoudian M, Cecone C, Caldera F, Zakeri-Milani P, Matencio A, et al. Stabilization and anticancer enhancing activity of the peptide nisin by cyclodextrin-based nanosponges against colon and breast cancer cells. Polymers. 2022;14:594.
Taka AL, Pillay K, Mbianda XY. Nanosponge cyclodextrin polyurethanes and their modification with nanomaterials for the removal of pollutants from wastewater: A review. Carbohydr Polym. 2017;159:94–107.
Arkas M, Allabashi R, Tsiourvas D, Mattausch EM, Perfler R. Organic/inorganic hybrid filters based on dendritic and cyclodextrin “nanosponges” for the removal of organic pollutants from water. Environ Sci Technol. 2006;40:2771–7.
Singh P, Ren X, Guo T, Wu L, Shakya S, He Y, et al. Biofunctionalization of β-cyclodextrin nanosponges using cholesterol. Carbohydr Polym. 2018;190:23–30.
Girigoswami JA, Girigoswami K. Versatile applications of nanosponges in biomedical field: A glimpse on SARS-CoV-2 management. BioNanoScience. 2022;12(3):1018–31.
Tiwari K, Bhattacharya S. The ascension of nanosponges as a drug delivery carrier: Preparation, characterization, and applications. J Mater Sci Mater Med. 2022;33(3):28.
Trotta F, Zanetti M, Cavalli R. Cyclodextrin-based nanosponges as drug carriers. Beilstein J Org Chem. 2012;8:2091–9.
Sharma R, Walker R, Pathak K. Evaluation of the kinetics and mechanism of drug release from econazole nitrate nanosponge loaded carbopol hydrogel. Indian J Pharm Educ Res. 2011;45:25–31.
Jani RK, Patel N, Patel Z, Chakraborthy GS, Upadhye V. Nanosponges as a biocatalyst carrier—An innovative drug delivery technology for enzymes, proteins, vaccines, and antibodies. Biocatal Agric Biotechnol. 2022;42:102329.
Menezes PDP, Andrade TA, Frank LA, Soares de Souza EPBS, Trindade GGG, Trindade IAS, et al. Advances of nanosystems containing cyclodextrins and their applications in pharmaceuticals. Int J Pharm. 2019;559:312–28.
Lee JS, Oh H, Kim S, Lee JH, Shin YC, Choi WI. A novel chitosan nanosponge as a vehicle for transepidermal drug delivery. Pharmaceutics. 2021;13:1329.
Taka AL, Fosso-Kankeu E, Pillay K, Yangkou Mbianda X. Metal nanoparticles decorated phosphorylated carbon nanotube/cyclodextrin nanosponge for trichloroethylene and Congo red dye adsorption from wastewater. J Environ Chem Eng. 2020;8:103602.
Swaminathan S, Vavia PR, Trotta F, Torne S. Formulation of betacyclodextrin-based nanosponges of itraconazole. J Inclusion Phenom Macrocycl Chem. 2007;57(1):89–94.
Setijadi E, Tao L, Liu J, Jia Z, Boyer C, Davis TP. Biodegradable star polymers functionalized with beta-cyclodextrin inclusion complexes. Biomacromolecules. 2009;10(9):2699–707.
Ghurghure S, Pathan M, Surwase P. Nanosponges: A novel approach for targeted drug delivery system. 2018;2581-348.
Iravani S, Varma RS. Nanosponges for drug delivery and cancer therapy: Recent advances. Nanomaterials. 2022;12(14).
Amani F, Rezaei A, Kharazmi MS, Jafari SM. Loading ferulic acid into β-cyclodextrin nanosponges; antibacterial activity, controlled release, and application in pomegranate juice as a copigment agent. Colloids Surf A Physicochem Eng Asp. 2022;649:129454.
Lamy L, François M, Bezdetnaya L, Yakavets I. Phototoxicity of temoporfin-loaded cyclodextrin nanosponges in stroma-rich three-dimensional models of head and neck cancer. Eur J Pharm Biopharm. 2023;184:1–6.
Desai D, Shende P. β-Cyclodextrin-crosslinked synthetic neuropeptide Y-based nanosponges in epilepsy by contributing GABAergic signal. Nanomedicine. 2022;45:102594.
Hafiz MA, Ghauri MA, Abbas N, Hussain T, Bukhari NI. Development of cervix-targeted hydrogel carrier for carboplatin-loaded nanosponges: In-vitro and ex-vivo evaluation. J Drug Deliv Sci Technol. 2023;84:104472.
Hao Y, Chen M, Wu Y, Dong Z, Zhu Y, Wang C, et al. CaCO3-based proton nanosponge to potentiate immune checkpoint blockade therapy by synergistically reversing tumor immunosuppression. Chem Eng J. 2023;462:142206.
Anwer MK, Fatima F, Ahmed MM, Aldawsari MF, Alali AS, Kalam MA, et al. Abemaciclib-loaded ethylcellulose-based nanosponges for sustained cytotoxicity against MCF-7 and MDA-MB-231 human breast cancer cell lines. Saudi Pharm J. 2022;30(6):726–34.
Jain A, Prajapati SK, Kumari A, Mody N, Bajpai M. Engineered nanosponges as versatile biodegradable carriers: An insight. J Drug Deliv Sci Technol. 2020;57:101643.
Ansari KA, Vavia PR, Trotta F, Cavalli R. Cyclodextrin-based nanosponges for delivery of resveratrol: In vitro characterisation, stability, cytotoxicity and permeation study. AAPS PharmSciTech. 2011;12(1):279–86.
Abou Taleb S, Moatasim Y, GabAllah M, Asfour MH. Quercitrin-loaded cyclodextrin-based nanosponge as a promising approach for management of lung cancer and COVID-19. J Drug Deliv Sci Technol. 2022;77:103921.
Sherje AP, Dravyakar BR, Kadam D, Jadhav M. Cyclodextrin-based nanosponges: A critical review. Carbohydr Polym. 2017;173:37–49.
Guo J, Xiao Y, Lin Y, Crommen J, Jiang Z. Effect of the crosslinker type on the enantioseparation performance of β-cyclodextrin functionalized monoliths prepared by the one-pot approach. J Chromatogr A. 2016;1467:288–96.
Girek T, Ciesielski W. Polymerization of β-cyclodextrin with maleic anhydride along with thermogravimetric study of polymers. J Inclusion Phenom Macrocycl Chem. 2011;69(3):445–51.
Modi A, Tayade P. A comparative solubility enhancement profile of valdecoxib with different solubilization approaches. Indian J Pharm Sci. 2007;69.
Layre AM, Gref R, Richard J, Requier D, Chacun H, Appel M, et al. Nanoencapsulation of a crystalline drug. Int J Pharm. 2005;298(2):323–7.
Vyas A, Saraf S, Saraf S. Cyclodextrin-based novel drug delivery systems. J Inclusion Phenom Macrocycl Chem. 2008;62(1):23–42.
Challa R, Ahuja A, Ali J, Khar RK. Cyclodextrins in drug delivery: An updated review. AAPS PharmSciTech. 2005;6(2):E329–E357.
Torne S, Darandale S, Vavia P, Trotta F, Cavalli R. Cyclodextrin-based nanosponges: Effective nanocarrier for tamoxifen delivery. Pharm Dev Technol. 2013;18(5):619–25.
Zhang K, Liu J, Song Q, Yang X, Wang D, Liu W, et al. DNA nanosponge for adsorption and clearance of intracellular miR-21 and enhanced antitumor chemotherapy. ACS Appl Mater Interfaces. 2019;11:46604–13.
Luo D, Lin X, Zhao Y, Hu J, Mo F, Song G, et al. A dynamic DNA nanosponge for triggered amplification of gene-photodynamic modulation. Chem Sci. 2022;13:5155–63.
Hafiz MA, Abbas N, Bukhari NI. Quality by design approach for formulation development and evaluation of carboplatin-loaded ethylcellulose nanosponges. Int J Polym Mater Polym Biomater. 2022;71:1012–24.
Klibanov AM, Schefiliti JA. On the relationship between conformation and stability in solid pharmaceutical protein formulations. Biotechnol Lett. 2004;26(14):1103–6.
Schwartz D, Sofia S, Friess W. Integrity and stability studies of precipitated rhBMP-2 microparticles with a focus on ATR-FTIR measurements. Eur J Pharm Biopharm. 2006;63(3):241–8.
Cavalli R, Akhter AK, Bisazza A, Giustetto P, Trotta F, Vavia P. Nanosponge formulations as oxygen delivery systems. Int J Pharm. 2010;402(1–2):254–7.
Appleton SL, Tannous M, Argenziano M, Muntoni E, Rosa AC, Rossi D, et al. Nanosponges as protein delivery systems: insulin, a case study. Int J Pharm. 2020;590:119888.
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