Multi-Scaler Fusion Framework for Pediatric Autism Prediction Using Ensemble Machine Learning and Feature Attribution
Abstract
In this study, we provide a machine learning framework for ASD early diagnosis that makes use of four remarkable feature
scaling methods and eight main machine learning algorithms. The suggested design makes use of four outstanding feature
scaling (FS) methods: quantile transformer (QT), power transformer (PT), normaliser, and max abs scaler (MAS). For the
feature-scaled datasets, eight trustworthy machine learning methods are utilised: AdaBoost (AB), Random forest (RF),
decision Tree (DT), k-Nearest neighbours (KNN), Gaussian Naïve Bayes (GNB), Logistic Regression (LR), guide Vector
system (SVM), and Linear Discriminant analysis (LDA). The study utilises four standard datasets on ASD: infants, young
adults, children, and adults. Basic function selection approaches and primary type algorithms for every ASD dataset are
observed. To get the most reliable results, use the normaliser FS on younger children and the QT FS method on older adults
and teens. In order to rank the important attributes in order of importance, four feature selection techniques (FSTs) are
used: information gain attribute evaluator (IGAE), gain ratio attribute evaluator (GRAE), relief F attribute evaluator (RFAE),
and correlation attribute evaluator (CAE). These FSTs are used to assess the risk factors for autism spectrum disorder (ASD).
Results from using the proposed paradigm for early ASD diagnosis are better than those from using current methods.
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Alrehaili, R. A., ElKady, R. M., Alrehaili, J. A., & Alreefi, R. M. (2023). Exploring early childhood autism
spectrum disorders: A comprehensive review of diagnostic approaches in young children. Cureus, 15(12).
Engelhard, M. M., Henao, R., Berchuck, S. I., Chen, J., Eichner, B., Herkert, D., ... & Dawson, G. (2023). Predictive
value of early autism detection models based on electronic health record data collected before age 1 year. JAMA
network open, 6(2), e2254303-e2254303.
Themistocleous, C. K., Andreou, M., & Peristeri, E. (2024). Autism Detection in Children: Integrating Machine
Learning and Natural Language Processing in Narrative Analysis. Behavioral Sciences, 14(6), 459.
Joudar, S. S., Albahri, A. S., Hamid, R. A., Zahid, I. A., Alqaysi, M. E., Albahri, O. S., & Alamoodi, A. H. (2023).
Artificial intelligence-based approaches for improving the diagnosis, triage, and prioritization of autism spectrum
disorder: a systematic review of current trends and open issues. Artificial Intelligence Review, 56(Suppl 1), 53-
Salari, N., Rasoulpoor, S., Rasoulpoor, S., Shohaimi, S., Jafarpour, S., Abdoli, N., ... & Mohammadi, M. (2022).
The global prevalence of autism spectrum disorder: a comprehensive systematic review and meta-analysis. Italian
Journal of Pediatrics, 48(1), 112.
Sheldrick, R. C., Carter, A. S., Eisenhower, A., Mackie, T. I., Cole, M. B., Hoch, N., ... & Pedraza, F. M. (2022).
Effectiveness of screening in early intervention settings to improve diagnosis of autism and reduce health
disparities. JAMA pediatrics, 176(3), 262-269.
Srinivasan, S., Ekbladh, A., Freedman, B., & Bhat, A. (2021). Needs assessment in unmet healthcare and family
support services: A survey of caregivers of children and youth with autism spectrum disorder in Delaware. Autism
Research, 14(8), 1736-1758.
Megerian, J. T., Dey, S., Melmed, R. D., Coury, D. L., Lerner, M., Nicholls, C. J., ... & Taraman, S. (2022).
Evaluation of an artificial intelligence-based medical device for diagnosis of autism spectrum disorder. NPJ digital
medicine, 5(1), 57.
Gopi, V. P., Francis, B., & Thomas, A. (2024). Early-stage identification of autism in children using gesture
monitoring based on artificial intelligence. In Advances in Artificial Intelligence (pp. 491-522). Academic Press.
Liu, M., & Ma, Z. (2022). A systematic review of telehealth screening, assessment, and diagnosis of autism
spectrum disorder. Child and adolescent psychiatry and mental health, 16(1), 79.
Jeon, I., Kim, M., So, D., Kim, E. Y., Nam, Y., Kim, S., ... & Moon, J. (2024). Reliable Autism Spectrum Disorder
Diagnosis for Pediatrics Using Machine Learning and Explainable AI. Diagnostics, 14(22), 2504.
Rajagopalan, S. S., Zhang, Y., Yahia, A., & Tammimies, K. (2024). Machine Learning Prediction of Autism
Spectrum Disorder From a Minimal Set of Medical and Background Information. JAMA Network Open, 7(8),
e2429229-e2429229.
Kumar, A., & Bhattacharya, S. (2024). Unveiling autism spectrum disorder in South East Asia through a public
health Lens. Frontiers in Child and Adolescent Psychiatry, 3, 1489269.
Pan, P. Y., Bölte, S., Kaur, P., Jamil, S., & Jonsson, U. (2021). Neurological disorders in autism: A systematic
review and meta-analysis. Autism, 25(3), 812-830.
Lucas, H. M., Lewis, A. M., Lupo, P. J., & Schaaf, C. P. (2022). Parental perceptions of genetic testing for children
with autism spectrum disorders. American Journal of Medical Genetics Part A, 188(1), 178-186
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