Phytochemical Screening Of Nardostachys Jatamansi (Jatamansi): Unveiling Its Therapeutic Bioactive Compounds
DOI:
https://doi.org/10.63682/jns.v14i29S.6874Keywords:
Nardostachys jatamansi, Phytochemical, pharmacological herbal drugAbstract
Nardostachys jatamansi (commonly known as Jatamansi) is a medicinal plant native to the Himalayan region, widely used in traditional medicine for its therapeutic properties. Phytochemical screening of Jatamansi is essential for identifying its bioactive compounds, which contribute to its pharmacological effects, including anti-inflammatory, antioxidant, and neuroprotective activities. This research presents an overview of the phytochemical constituents found in Nardostachys jatamansi and their potential medicinal applications. The preliminary phytochemical analysis of Nardostachys jatamansi root and aerial parts reveals the presence of a wide range of bioactive compounds, including alkaloids, flavonoids, tannins, saponins, phenolic compounds, glycosides, and essential oils. Alkaloids such as nardostachysin and jatamansone, found in the roots, are known for their sedative and anticonvulsant effects. Flavonoids, particularly quercetin, contribute to the plant's antioxidant properties, protecting cells from oxidative stress. Tannins and phenolic compounds exhibit strong antimicrobial and anti-inflammatory activities. Saponins and glycosides are noted for their immunomodulatory and anti-cancer properties, suggesting potential therapeutic applications in immune system regulation and cancer treatment. In conclusion, the phytochemical constituents of Nardostachys jatamansi play a vital role in its therapeutic efficacy, supporting its use in traditional medicine. However, further research, including clinical trials and advanced pharmacological studies, is necessary to validate its medicinal potential and optimize its therapeutic applications.
Downloads
Metrics
References
Jyotsna S. S., Sonali S. K., Suchita L. S., Sushmita S. C., Sonali B. H., Need of Polyherbal Formulations and Its, Standardization: A Review, World Journal of Pharmacy and Pharmaceutical Sciences, Vol. 5(11), pp. 526-533.
Obidike I., Salawu O., Screening of Herbal Medicines for Potential Toxicities, New Insights into Toxicity and Drug Testing, 2013, pp. 64-70.
Sanjoy K. P., Yogeshwer S., Herbal Medicine: Current Status and the Future, Asian Pacific Journal of Cancer Prevention, Vol. 4, 2003, 281-290.
V. P. Kamboj, Herbal medicine, Current Science, Vol. 78(1), 2010, 35-50.
Mohd. M., Taqi A.K., Firoz M., Medicinal Plants of Rural India: A Review of Use by Indian Folks, Indo Global Journal of Pharmaceutical Sciences, Vol. 2(3), 2012, 286-304.
S.M.K. Rates, Plants as source of drugs, Toxicon, Vol. 39, 2001, 603–613.
Arun R., Sravya R.B, Roja C., A Review on Standardisation of Herbal Formulation, International Journal of Phytotherapy, Vol 2(2), 2012, 74-88.
Vijay, K.P., Chauhan, R.S., Harish C.A., Prasad, P., Nautiyal, M.C. and Nautiyal, A.R., 2012. Nardostachys jatamansi DC: Conservation, multiplication and policy issues. Medicinal plants, Vol. 4(3): pp.1-5.
Purnima, Meenakshi, B., and Preeti K., 2015. A review article on phytochemistry and pharmacological profiles of Nardostachys jatamansi DC-medicinal herb. Journal of phytochemistry and pharmacognosy, Vol. 3(5): pp. 102-106.
Jadhav, V.M., Thorat, R.M., Kadam, V.J., and Kamble, S.S., 2009. Herbal anxiolyte:
Nardostachys jatamansi. Journal of pharmacy and research, Vol. 2(8): pp. 1208-1211.
The ayurvedic pharmacopoeia of India. 1964. Government of India Ministry of Health and Family Welfare Department of Ayush, Part 1, Vol. 1: pp. 79-81.
Singh, V., Dubey, P., Srivastava, S., and Rawat, A.K.S., 2011. Botanical standardization of the jatamansi their substitute and adultrant species. India journal of traditional knowledge, Vol. 10(4): pp. 599-603.
Uma, M.S., Vijayata, G., Vivekanand, P.R., Rakesh, S.S., Manoj, K.Y., 2013. A review on biological activities and conservation of endangered medicinal herb Nardostachys jatamansi. Vol. 3: pp. 113-124.
Chaterjee, A., Basak, B., Datta, U., Banerji, J., Neuman., and Prenge, T., 2005. Studies on chemical constituents of of Nardostachys jatamansi DC (Valerianaceae). Vol. 44B: pp. 430- 433.
Nasrolah, G.D., Ebrahim, S., Hamed, S.K., Mahtab, K., Seyyed-Masih H., 2014. Identification of chemical compounds of Nardostachys Jatamansi essence available in Iran, Journal of Herbmed Pharmacology, 3(2), 83-86.
Amit, K.M., Sunil, K, 2013. A Phytopharmacological Review on N. Jatamansi. An International Journal of Pharmacy Research, Vol. 9(02): pp. 21-32.
Ashfaq, A., Munavvar, Z.A.S., Hassaan, A.R., Tabinda, F., Safia, A.K., Sheryar, A., Mohamed, L., Fiaz, U.A. and Eseyin, O., 2013. Pharmacological importance of Nardostachys jatamansi DC: A potential therapeutic agent in different pathological ailments. Journal of chemical and pharmaceutical Research, Vol. 5(10): pp. 431-438.
Sharma N, Sharma A.R., Patel B.D., Shrestha K. Investigation on phytochemical, antimicrobial activity and essential oil constituents of Nardostachys jatamansi DC. in different regions of Nepal. Journal of Coastal life medicine, 2016; Vol. 4(1): pp. 56-60.
Syed AR, Syed AA. Anti-ulcer activity of Nardostachys jatamansi against pylorous ligation induced gastric ulcer. Scholars Journal of Applied Medical Science, 2016; 4(8E): pp. 3048- 3055.
Foroogh N, Mohammad EA, Elahe A, Niloufar G, Khadijeh N. Angiotensin I Converting Enzyme Inhibitory Activities of Hydroalcoholic Extracts of Nardostachys jatamansi, Prangos ferulacea and Marrubium vulgare. 2015; pp. 1-11.
Sivajothi V, Shruthi SD, Sudha Bhargavi, and A Muthukumar. Evaluation of In-vitro Cytotoxicity of Monochoria vaginalis, Ipomoea carnea, Nardostachys Jatamansi Extracts on Hela Cells. Research Journal of Pharmaceutical, Biological and Chemical Sciences, 2015; 6(4): pp. 698-705.
Toolika E, Ravi M, Narayana PB, Suhas KS, Ravishankar B, Savitha HP. A comparative pharmacological study on the effect of Tagara (Valeriana wallichii) and Jatamansi (Nardostachys jatamansi) in the management of anidra w.s.r to primary insomnia. The Journal of Phytopharmacology, 2015; 4(3): pp. 147-151.
Aleem MA, Syed Asad B, Tasneem M, Riyaz Ahmed K, M. Farooq A, Anjum A and M. Ibrahim. Antidiabetic Activity of Hydroalcoholic Extracts of Nardostachys jatamansi in Alloxan-induced Diabetic Rats. British Journal of Medicine & Medical Research, 2014; 4(28): pp. 4665-4673.
Digvijay GK, Netaji TN, Nitin BG and Shrinivas KS. Evaluation of diuretic activity of ethanolic and petroleum ether extracts of Nardostachys jatamansi DC roots in rats. 2014; 5(4): pp. 27-31.
Rajnish KS, Vaishali, Susanta KP, Padala NM, Ghanashyam P, Pramod K, Ramesh KG. Evaluation of anti-inflammatory potential of Nardostachys jatamansi rhizome in experimental rodents. Journal of coastal life medicines, 2014; 2(1): pp. 38-43.
Xin Chao Liu and Zhi Long Liu. Evaluation of insecticidal activity of Nardostachys jatamansi essential oil against some grain storage insects. Journal of Entomology and Zoology Studies, 2014; 2(4): pp. 335-340.
Damodara G KM, Lathika S, Krishna A.P, Suchetha Kumari N, Ganesh S, Naveen P. & Sharada V. Ethanolic extractr of Nardostachys Jatamansi potentiates haematopoietic system in albino wistar rats. Journal of Health Sciences, 2013; Vol. 3: pp. 25-29.
Deepa B, Shucheta K, Sateesh Rao. Antidepressant activity of Nardostachys jatamansi in electron beam irradiated light. 2013; 4(1): pp. 101-103.
Madhulika B, Renu Moti P and Ajit K. In vitro and In vivo Biological Activities of Nardostachys Jatamansi Root. 2013; pp. 1-10.
Madhu L.N., Suchetha k., Naveen and Sanjeev. Protective Effect of Nardostachys jatamansi Against Radiation -induced Damage at Biochemical and Chromosomal Levels in Swiss Albino Mice. Indian Journal of Pharmaceutical Sciences, 2012; pp. 460-470.
Rasheed A, Venkataraman S, Jayaveera KN and Mohammed YJ. Phytochemical, Toxicological Evaluation and Anticataleptic Activity of Nardostachys Jatamansi. Asian Journal of Pharmaceutical and Clinical Research, 2012; Vol. 5: pp. 200-206.
Velpandian V, Sathya B, Mohammed M, Anbu N. A Clinical Evaluation of Nardostachys jatamansi in the Management of Essential Hypertension. International Journal of Pharmaceutical and Phytopharmacological Research, 2012; 2(2): pp. 96-100.
Zahida P, Saima S, Muafia S, Shaista JK and Razia K. Volatile constituents, antibacterial and antioxidant activities of essential oil from nardostachys jatamansi DC roots. 2011; Vol. 3:pp. 329-337.
Nazmun L, Dipankar B, Tapas K.S, Santanu M, Shurita P, Suparna C, and Antony G. Stress modulating antioxidant effect of Nardostachys jatamansi. Indian Journal of Biochemistry and Biophysics, 2009; Vol. 46: pp. 93-98.
Shubhasini R, Ganapargasam A, Senthilkumar S, Yoogeta S.K, Deveki T. Protective efficacy of N. jatamansi (rhizomes) on mitochondrial respiration and lysosomal hydrolases during doxorubicin induced myocardial injury in rats. Journal of health sciences, 2007; 53(1): pp. 67-76.
National cholesterol education program: Second report of the expert panel on detection, evaluation and treatment of high blood cholesterol in adults, Vol. 89, 1994, 1333-1445.
National Cholesterol Education Program, ATP III Guidelines At-A-Glance Quick Desk Reference, Determine lipoprotein levels–obtain complete lipoprotein profile after 9- to 12- hour fast, Vol 85, 1990, 1567-1570.
Huynh Ngoc T, Nguyen Ngoc Q, Tran T Van A,Vo Phung N. Hypolipidemic Effect of Extracts from Abelmoschus esculentus L. (Malvaceae) on Tyloxapol-Induced Hyperlipidemia in Mice: Mahidol University. Journal of Pharmaceutical Sciences, Vol. 35(1- 4), 2008, 42-46.
Kishor J.S., Kathivarin M.K, Rahul S., Journal of the biology and chemistry of hyperlipidemia. Bioorganic and Medicinal Chemistry, Vol. 15, 2007, 4674-4699.
Ankur R., Nidhi D., Seema R., Amarjeet D., Ashok K., Hyperlipidemia- A Deadly Pathological Condition, International Journal of Current Pharmaceutical Research, Vol. 4(3), 2012, 15-18.
Downloads
Published
How to Cite
Issue
Section
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
You are free to:
- Share — copy and redistribute the material in any medium or format
- Adapt — remix, transform, and build upon the material for any purpose, even commercially.
Terms:
- Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
