Anti-Allergic Activity and Mast Cell Stabilization of Areal Parts of Solnum Torrvum on Experimental Animals
Keywords:
Solanum torvum, Anti-allergic, Leukocytes, Eosinophils, Mast cellsAbstract
A Solanum torvum (Solanaceae) areal part of plant has been extensively in traditional medicine for the treatment of asthma and bronchitis. The present study was designed to evaluate the anti-allergic activity of hydro- alcoholic extract of solanum torvum. Areal parts of plant in experimental animals. The ant allergic activity of the extract was evaluated on compound 48/80 induced mast cell degranulation in rat mesentery and milk induced leukocytes and eosinophilia in mice. Treatment of HAST (300 and 600 mg/kg p.o.) showed significant (p<0.001) protection against compound 48/80 (1 mg/kg s.c.)-induced mast cell degranulation mesenteric pans. The hydro alcoholic extract of S. torvum Areal parts of plant inhibited milk induced model Pre-treatment of HAST (200 and 400 mg/kg, p.o.) to group of mice exhibited significantly (p<0.001) reduced the milk (4 ml/kg s.c.)-induced elevated levels of blood total leukocyte and eosinophils counts. The observed beneficial effect of title plant may be attributed to reported bioactive compounds and their synergistic outcome.
Downloads
Metrics
References
Han S, Sun L, He F, Che H. Anti-allergic activity of glycyrrhizic acid on IgE-mediated allergic reaction by regulation of allergy-related immune cells. Scientific reports. 2017 Aug 3;7(1):7222.
Larché M, Akdis CA, Valenta R. Immunological mechanisms of allergen-specific immunotherapy. Nature Reviews Immunology. 2006 Oct;6(10):761.
Kubo T, Morita H, Sugita K, Akdis CA. Introduction to mechanisms of allergic diseases.In Middleton's Allergy Essentials 2017 Jan 1 (pp. 1-27). Elsevier.
Bousquet J, Bousquet PJ, Godard P, Daures JP. The public health implications of asthma.Bulletin of the World Health Organization. 2005; 83:548-54.
Pawankar R. Allergic diseases and asthma: a global public health concern and a call to action. World Allergy Organization Journal. 2014 Dec;7:1-3.
Lupa M, Samulowska M, Chmielewski S, Myszkowska D, Czarnobilska E. a concept of webgis pollen allergy mapping. international multidisciplinary Scientific GeoConference: SGEM: Surveying Geology & mining Ecology Management. 201; 17:1141-8.
Ring J, Akdis C, Behrendt H, Lauener RP, Schäppi G, Akdis M, Ammann W, de Beaumont O, Bieber T, Bienenstock J, Blaser K. Davos declaration: allergy as a global problem. Allergy. 2012 Feb;67(2):141-3.
Chandrika D. Allergic rhinitis in India: an overview. Int J Otorhinolaryngol Head Neck Surg. 2017 Jan;3(1):1-6.
Day J. Pros and cons of the use of antihistamines in managing allergic rhinitis. Journalof allergy and clinical immunology. 1999 Mar 1;103(3): S395-9.
Warrington TP, Bostwick JM. Psychiatric adverse effects of corticosteroids. InMayo Clinic Proceedings 2006;81(10):1361-1367.
Prakash J, Srivastava S, Ray RS, Singh N, Rajpali R, Singh GN. Current Status of Herbal Drug Standards in the Indian Pharmacopoeia. Phytotherapy research. 2017 Dec;31(12):1817-23.
WHO Rsearch Guidelines for Evaluating the Safety and Efficacy of Herbal Medicines.Published By World Health Organization, Regional Office For The Western Pacific, Manila.1993:1-10.
Soorya R, Dhamodaran P, Rajesh Kr, Duraisamy B. In Silico Studies Of The Secondary Metabolites Of Solanum Torvum Sw. For Their Antiasthmatic Activity. Int J Curr Pharm Res. 2017;9(4):38-41.
JaiswalBS. Solanum torvum: a review of its traditional uses, phytochemistry and pharmacology. International Journal of Pharma and Bio Sciences. 2012 Oct;3(4):104 -11.
Abu-Rabia A. Urinary diseases and ethnobotany among pastoral nomads in the Middle East. Journal of Ethnobiology and Ethnomedicine. 2005 Dec;1:1-3.
Lev E. Ethno-diversity within current ethno-pharmacology as part of Israeli traditional medicine–A review. Journal of Ethnobiology and ethnomedicine. 2006 Dec;2:1-2.
Kannan M, Singh AR, Kumar TA, Jegatheswari P, Subburayalu S. Studies on immuno-bioactivities of Nyctanthes arbortristis (Oleaceae). African Journal of Microbiology Research. 2007 Nov 1;1(6):088-91.
Mbadiko CM, Matondo A, Bongo GN, Inkoto CL, Gbolo BZ, Lengbiye EM, Kilembe JT, Mwanangombo DT, Ngoyi EM, Falanga CM, Tshibangu DS. Review on ethno-botany, virucidal activity, phytochemistry and toxicology of solanum genus: Potential bio- resources for the therapeutic management of COVID-19. European Journal of Nutrition & Food Safety. 2020 Jul 13:35-48.
Harish MS, Nagur M, Badami S. Antihistaminic and mast cell stabilizing activity of Strigaorobanchioides. J Ethnopharmacol. 2001; 76:197-200.
.Naik SR, BhagatSushant, Shah PD, Tare AA, Ingawale D, Wadekar RR. Evaluation of antiallergic and ant anaphylactic activity of ethanolic extract of Zizyphusjujub fruits in rodents. Braz J Pharmacol. 2013; 23:811-18.
Tewtrakul, S, Itharat, A, Anti-allergicsubstancesfromtherhizomesof Dioscoreamembranacea. Bioorganic and MedicinalChemistry.2006;14:8707–8711.
Darkwah WK, Koomson DA, Miwornunyuie N, Nkoom M, Puplampu JB. Phytochemistry and medicinal properties of Solanum torvum fruits. All Life. 2020;13(1):498-506.
Kumar M, Duraisamy K, Chow BK. Unlocking the non-IgE-mediated pseudo-allergic reaction puzzle with mas-related G-protein coupled receptor member X2 (MRGPRX2). Cells. 2021 Apr 27;10(5):1033.
..
Downloads
Published
How to Cite
Issue
Section
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
You are free to:
- Share — copy and redistribute the material in any medium or format
- Adapt — remix, transform, and build upon the material for any purpose, even commercially.
Terms:
- Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
