Comparing the Effectiveness of Bacterial Nanocellulose Dressing and Silver Sulphadiazine in Mid Dermal Burn Wound: A Systematic Review

Authors

  • Ida Bagus Nyoman Ananta Awatara
  • Lobredia Zarasade
  • Lynda Hariani

Keywords:

Mid Dermal Burn, Silver Sulphadiazine, Bacterial Nanocellulose Dressing, Epitalization Rate, Human & Health, Medicine

Abstract

Burns are damage to the skin that were caused by heat or cold trauma (frost bite). This damage can include tissue under the skin and can also cause systemic problems that will require a very long treatment time. Silver Sulfadiazine (SSD) is the most common topical antimicrobial treatment for burns. Silver Sulphadiazine has been found to have a cytotoxic effect on fibroblast cells, thereby affecting the wound healing process. Bacterial nanocellulose dressing is a new type of dressing that is currently performing and researched. Bacterial nanocellulose dressings properties are suitable for wound healing, but they lack antibacterial properties. This quantitative Systematic Review design aims to study the effectiveness of Bacterial Nanocellulose Dressing compared to Silver Sulfadiazine in patients with mid dermal burns. The variable studied was the rate of epithelialization. Studies were selected from various databases within the last 20 years. After selecting studies that meet the inclusion criteria, exclusion criteria and assessing the quality of the literature, the selected studies will be processed. Study selection using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) method, from the database search obtained 7 articles on the Pubmed database and 5 articles on the Cochrane database.  Then the studies were excluded again based on the title and abstract so that 2 studies remained and were analyzed in this study. Both studies were randomized controlled clinical trials, and a total of 100 samples were obtained. The samples were split into two groups, Silver Sulfadiazine control group and Bacterial Nanocellulose Dressing intervention group. From the results of the study, it was described that there was a difference between the epitalization rate in the SSD group and the bacterial nanocellulose group. The study by Aboelnaga et al., 2018, stated that by multivariable regression analysis, the mean epithelialization rate of the nanocellulose group was 4.3 days faster than the SSD group, without any significant difference. And a study by Piatkowski et al., 2011, said that the healing time in both treatment groups was similar. From the findings, it can be concluded that Bacterial Nanocellulose Dressing has the ability to accelerate the rate of epithelialization in burn wounds compared to SSD. Apart from the rate of epithelialization, Bacterial Nanocellulose Dressing is better in terms of pain and more cost effective than SSD.

Downloads

Download data is not yet available.

References

N. Sjaifudin, D. . Perdanakusuma, and R. S, Basic principles and emergency examination in burn injury. Emegerncy Management of Major Burn, Surabaya. Revka Petra Media, 2018.

American Burn Association, ’Advanced burn life support course provider Manual, American Burn Asociation. 2018.

Lensoni, A. Nurdin, and In Erosida, “Identification Of Community Disease Symptoms Around Community Gold Mines In Terms Of Length Of Stay (>5 Years) In The Working Area Of The Uptd Puskesmas Ujung Padang Rasian, South Aceh District,” Pharmacol. Med. REPORTS, Orthop. Illn. DETAILS, vol. 3, no. 2, pp. 41–50, Apr. 2024, doi: 10.55047/comorbid.v3i2.1124.

A. Heyneman, H. Hoeksema, D. Vandekerckhove, A. Pirayesh, and S. Monstrey, “The role of silver sulphadiazine in the conservative treatment of partial thickness burn wounds: A systematic review,” Burns, vol. 42, no. 7, pp. 1377–1386, 2016, doi: 10.1016/j.burns.2016.03.029.

R. I. Kemenkes, “Profil kesehatan Indonesia tahun 2019,” Kementrian Kesehat. Repoblik Indones., vol. 42, no. 4, p. 1, 2019.

A. Adhya et al., “Healing of burn wounds by topical treatment: A randomized controlled comparison between silver sulfadiazine and nano-crystalline silver,” J. basic Clin. Pharm., vol. 6, no. 1, pp. 29–34, 2014, doi: 10.4103/0976-0105.145776.

N. Martina and A. Wardhana, “Mortality analysis of adult burn patients in Uruguay,” J. Plast. Rekonstruksi, vol. 9, no. 2, pp. 96–100, 2015, doi: 10.5935/0103-507X.20200008.

P. R. Kala and R. Jannah, “Analysis Of The Effectiveness Of The Family Hope Program On Stunting In Children Aged 24-36 Months In Kuta Baro Sub-District, Aceh Besar District,” Public Health, vol. 1, p. 2, doi: 10.55047/comorbid.v2i3.1103.

J. Cattelaens et al., “The impact of a nanocellulose-based wound dressing in the management of thermal injuries in children: results of a retrospective evaluation,” Life, vol. 10, no. 9, p. 212, 2020, doi: 10.3390/life10090212.

A. Vloemans, M. H. E. Hermans, M. B. A. Van Der Wal, J. Liebregts, and E. Middelkoop, “Optimal treatment of partial thickness burns in children: a systematic review,” Burns, vol. 40, no. 2, pp. 177–190, 2014, doi: 10.1016/j.burns.2013.09.016.

E. Wilson, “Emergency Management of Severe Burns (EMSB),” J. Paramed. Pract., vol. 4, no. 2, pp. 114–115, 2012, doi: 10.12968/jpar.2012.4.2.114.

D. J. Barillo and D. E. Marx, “Silver in medicine: A brief history BC 335 to present,” Burns, vol. 40, pp. S3–S8, 2014, doi: 10.1016/j.burns.2014.09.009.

Z. Aziz and B. A. R. Hassan, “The effects of honey compared to silver sulfadiazine for the treatment of burns: A systematic review of randomized controlled trials,” Burns, vol. 43, no. 1, pp. 50–57, 2017, doi: 10.1016/j.burns.2016.07.004.

A. Stanisławska, “Bacterial nanocellulose as a microbiological derived nanomaterial,” Adv. Mater. Sci., vol. 16, no. 4, pp. 45–57, 2016, doi: 10.1515/adms‐2016‐0022.

B. J. Bryant and K. M. Knights, Pharmacology for health professionals. Elsevier Australia, 2011.

J. Cambiaso-Daniel, J. J. Gallagher, W. B. Norbury, C. C. Finnerty, D. N. Herndon, and D. M. Culnan, “Treatment of infection in burn patients,” in Total burn care, Elsevier, 2018, pp. 93–113. doi: 10.1016/B978-0-323-47661-4.00011-3.

G. Helenius, H. Bäckdahl, A. Bodin, U. Nannmark, P. Gatenholm, and B. Risberg, “In vivo biocompatibility of bacterial cellulose,” J. Biomed. Mater. Res. Part A An Off. J. Soc. Biomater. Japanese Soc. Biomater. Aust. Soc. Biomater. Korean Soc. Biomater., vol. 76, no. 2, pp. 431–438, 2006, doi: 10.1002/jbm.a.30570.

U.-C. Hipler and P. Elsner, Biofunctional textiles and the skin, vol. 33. Karger Medical and Scientific Publishers, 2006.

C. H. Thorne, Grabb and Smith’s plastic surgery. Lippincott Williams & Wilkins, 2013.

M. D. Holbert et al., “Effectiveness of a hydrogel dressing as an analgesic adjunct to first aid for the treatment of acute paediatric thermal burn injuries: study protocol for a randomised controlled trial,” Trials, vol. 20, pp. 1–13, 2019, doi: 10.1186/s13063-018-3057-x.

Y. A. Kara, “Burn etiology and pathogenesis,” Hot Top. Burn Inj., vol. 17, no. 1, 2018, doi: 10.5772/intechopen.71379.

R. Oaks and R. Cindass, ‘Silver Sulfadiazine’, StatPearls. 2020.

K. Nuutila and E. Eriksson, “Moist wound healing with commonly available dressings,” Adv. wound care, vol. 10, no. 12, pp. 685–698, 2021, doi: 10.1089/wound.2020.1232.

I. Nur and W. Putri, “Perbandingan efektivitas silver sulfadiazine dan madu dalam penyembuhan luka bakar,” Essence Sci. Med. J., pp. 15–18, 2019.

Y.-I. Shen, H.-H. G. Song, A. E. Papa, J. A. Burke, S. W. Volk, and S. Gerecht, “Acellular hydrogels for regenerative burn wound healing: translation from a porcine model,” J. Invest. Dermatol., vol. 135, no. 10, pp. 2519–2529, 2015, doi: 10.1038/jid.2015.182.

I. D. Saputro and B. Dini, “Evaluation of burn unit GBPT performance from 2006-2008. A retrospective study,” Folia Medica Indones., vol. 47, no. 1, p. 1, 2011.

A. Aboelnaga et al., “Microbial cellulose dressing compared with silver sulphadiazine for the treatment of partial thickness burns: A prospective, randomised, clinical trial,” Burns, vol. 44, no. 8, pp. 1982–1988, 2018, doi: 10.1016/j.burns.2018.06.007.

A. Piatkowski, N. Drummer, A. Andriessen, D. Ulrich, and N. Pallua, “Randomized controlled single center study comparing a polyhexanide containing bio-cellulose dressing with silver sulfadiazine cream in partial-thickness dermal burns,” Burns, vol. 37, no. 5, pp. 800–804, 2011, doi: 10.1016/j.burns.2011.01.027

Published

2025-06-03

How to Cite

1.
Nyoman Ananta Awatara IB, Zarasade L, Hariani L. Comparing the Effectiveness of Bacterial Nanocellulose Dressing and Silver Sulphadiazine in Mid Dermal Burn Wound: A Systematic Review. J Neonatal Surg [Internet]. 2025Jun.3 [cited 2025Oct.2];14(8):211-6. Available from: https://www.jneonatalsurg.com/index.php/jns/article/view/6977